A5041182793- Heavy Metal Exposure and Toxicity
- Trace Elements in Health
- Neuroinflammation and Neurodegeneration Mechanisms
- Air Quality and Health Impacts
- Metallurgy and Material Forming
- Barrier Structure and Function Studies
- Circular RNAs in diseases
- Alzheimer's disease research and treatments
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Microscopic Colitis
- Gold and Silver Nanoparticles Synthesis and Applications
- Clostridium difficile and Clostridium perfringens research
- Drug Transport and Resistance Mechanisms
- Force Microscopy Techniques and Applications
- Nosocomial Infections in ICU
- Cervical Cancer and HPV Research
- Advanced Nanomaterials in Catalysis
- Heavy metals in environment
- Hepatitis B Virus Studies
- Microstructure and mechanical properties
- 3D Shape Modeling and Analysis
- High-Velocity Impact and Material Behavior
- Fluoride Effects and Removal
- Anesthesia and Neurotoxicity Research
North China University of Science and Technology
2016-2025
Stomatology Hospital
2022-2025
Sun Yat-sen University
2019-2025
Gansu Agricultural University
2025
North China University of Technology
2024
Nanjing Agricultural University
2024
Shenzhen Maternity and Child Healthcare Hospital
2024
Tropical Crops Genetic Resources Institute
2023
Chinese Academy of Tropical Agricultural Sciences
2023
Southwest Forestry University
2023
Cognitive impairment and Alzheimer's disease are linked with intake of a Western diet, characterized by high levels saturated fats simple carbohydrates. In rats, these dietary components have been shown to disrupt hippocampal-dependent learning memory processes, particularly those involving spatial memory. Using rat model, the present research assessed degree which consumption high-energy (HE) similar found in modern cultures, produces selective hippocampal function as opposed more global...
ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTRecent Progress in Fast Sample Preparation TechniquesLing XiaLing XiaSchool of Chemistry, Sun Yat-sen University, Guangzhou 510275, ChinaMore by Ling XiaView Biography, Jiani YangJiani YangSchool YangView Rihui SuRihui SuSchool SuView Wanjun ZhouWanjun ZhouSchool ZhouView Yanshu ZhangYanshu ZhangSchool ZhangView Yanhui ZhongYanhui ZhongSchool ZhongView Simin HuangSimin HuangSchool HuangView Yanlong ChenYanlong ChenSchool ChenView and Gongke...
Fluoride and arsenic are two common inorganic contaminants in drinking water that associated with impairment child development retarded intelligence. The present study was conducted to explore the effects on spatial learning, memory, glutamate levels, group I metabotropic receptors (mGluRs) expression hippocampus cortex after subchronic exposure fluoride, arsenic, a fluoride combination rats. Weaned male Sprague-Dawley rats were assigned four groups. control drank tap water. Rats three...
Characterization of the dynamic change in immunological landscape during malignant transformation from precancerous lesions to cancerous squamous cell carcinoma (SCC) is critical for application immunotherapy. Here, we performed single-cell RNA-Seq (scRNA-Seq) 131,702 cells 13 tissues oral (OSCC), 3 samples leukoplakia, and 8 adjacent normal samples. We found that tumor-infiltrating CD4+ CD8+ T were functionally inhibited by immunosuppressive ligands expressed on various types myeloid or...
An increasing number of studies have clarified that ferroptosis plays a vital role in neurodegenerative diseases, which is characterized by the accumulation Fe2+, lipid peroxidation, and alteration mitochondrial structure. However, whether involved nerve injury caused lead exposure remains unclear. In this study, HT22 cells mice were treated with acetate to investigate neurotoxicity. The results showed resulted an increase malondialdehyde (MDA) levels, decrease glutathione (GSH) levels vivo...
This phase II/III, double-blind, randomized trial assessed the efficacy, immunogenicity and safety of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine in young Chinese women (ClinicalTrials.gov registration NCT00779766). Women aged 18-25 years from Jiangsu province were (1:1) to receive HPV (n = 3,026) or Al(OH)3 control 3,025) at months 0, 1 6. The primary objective was efficacy (VE) against HPV-16/18 associated 6-month persistent infection (PI) and/or cervical intraepithelial...
Regulation of cellular copper (Cu) homeostasis involves Cu-transporting ATPases (Cu-ATPases), i.e., ATP7A and ATP7B. The question as to how these Cu-ATPases in brain barrier systems transport Cu, toward parenchyma, cerebrospinal fluid (CSF), or blood, remained unanswered. This study was designed characterize roles regulating Cu at the blood-brain (BBB) blood-CSF (BCB) investigate exposure toxic manganese (Mn) altered function Cu-ATPases, thereby contributing etiology Mn-induced parkinsonian...
The major components of traffic pollution particulate matter, diesel exhaust particles (DEPs), are airborne ultrafine (UFPs). DEPs can enter the central nervous system (CNS), where they may cause neurotoxicity.We established murine models with intranasal instillation in male C57BL/6 and Nlrp3 knock-out (Nlrp3-/-) mice to investigate effects exposure on neurobehaviors related mechanisms. Morris water maze (MWM) tests were performed evaluate learning memory behaviors following instillation....
Abstract Background Cervical cancer is a major public health concern in China. We report the end‐of‐study results of phase II/III trial to assess efficacy, immunogenicity, and safety AS04‐human papillomavirus (HPV)‐16/18 vaccine Chinese women aged 18‐25 years followed for up 72 months after first vaccination. Results approximately 57 following vaccination have been previously reported. Methods Healthy 18‐25‐year‐old (N = 6051) were randomized (1:1) receive three doses AS04‐HPV‐16/18 or...
Periodontal regeneration, specifically the restoration of cementum-periodontal ligament (PDL)-alveolar bone complex, remains a formidable challenge in field regenerative dentistry. In light periodontal development, harnessing multi-tissue developmental capabilities cells (PDLCs) and reinitiating process hold great promise as an effective strategy to foster regeneration complex. This study aims delve into potential effects macrophage-mediated immune microenvironment on "developmental...
Stephania japonica is an early-diverging eudicotyledon plant with high levels of cepharanthine, proven to be effective in curing coronavirus infections. Here, we report a high-quality S. genome. The genome size 688.52 Mb, and 97.37% sequences anchor 11 chromosomes. comprises 67.46% repetitive 21,036 genes. It closely related two Ranunculaceae species, which diverged from their common ancestor 55.90–71.02 million years ago (Mya) whole-genome duplication 85.59–96.75 Mya. We further reconstruct...
Characterization of systemic performance gold nanostructures is critical to the advancement biomedical applications these nanomaterials as imaging or therapeutic agents. The accuracy current in vitro methods, however, limited by interanimal variability. We present a novel method capable monitoring pharmacokinetics PEGylated nanorods (GNRs) same animal using intravital two-photon luminescence (TPL) GNRs flowing through surface blood vessel. TPL with high speed and submicrometer resolution...
Abstract We previously reported the results of a phase II/III, double‐blind, randomized controlled study in Chinese women (NCT00779766) showing 94.2% (95% confidence interval: 62.7–99.9) HPV‐16/18 AS04‐adjuvanted vaccine efficacy (VE) against cervical intraepithelial neoplasia grade 1 or higher (CIN1+) and/or 6‐month (M) persistent infection (PI) with mean follow‐up <2 years, and immunogenicity until 7 months post‐dose 1. Here, we report safety from an event‐triggered analysis ~3 years...
Glioma cells are characterized by high migration ability, resulting in aggressive growth of the tumors and poor prognosis patients. It has been reported that stress-induced hormone norepinephrine (NE) contributes to tumor progression through mediating a number important biological processes various cancers. However, role NE regulation glioma is still unclear. Epithelial-to-mesenchymal transition (EMT) one most steps for metastasis. Twist1, as key regulator EMT, found be elevated during...
Environmental stresses are ubiquitous in agricultural cultivation, and they affect the healthy growth development of edible tissues passion fruit. The study resistance mechanisms is important understanding adaptation plants to environmental stresses. In this work, two differently resistant fruit varieties were selected, using expression characteristics transcription factor MYB, explore mechanism MYB gene under various A total 174 family members identified high-quality genomes: 98 2R-MYB, 5...
Surrogate models are critical for accelerating computationally expensive simulations in science and engineering, particularly solving parametric partial differential equations (PDEs). Key challenges developing practical surrogate include managing high-dimensional inputs outputs handling geometrically complex variable domains, which often represented as point clouds. In this work, we systematically investigate the formulation of neural operators on clouds introduce Point Cloud Neural Operator...