A5081842876- Mosquito-borne diseases and control
- Malaria Research and Control
- Carcinogens and Genotoxicity Assessment
- Heavy Metal Exposure and Toxicity
- Occupational and environmental lung diseases
- Toxic Organic Pollutants Impact
- Cancer-related molecular mechanisms research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Viral Infections and Vectors
- Air Quality and Health Impacts
- DNA Repair Mechanisms
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Inflammasome and immune disorders
- Effects and risks of endocrine disrupting chemicals
- Heavy metals in environment
- Epigenetics and DNA Methylation
- Medical Imaging and Pathology Studies
- Dengue and Mosquito Control Research
- Per- and polyfluoroalkyl substances research
- Insect Pest Control Strategies
- Nanoparticles: synthesis and applications
- Autophagy in Disease and Therapy
- RNA modifications and cancer
- Ophthalmology and Visual Impairment Studies
Chengdu University of Traditional Chinese Medicine
2024-2025
The University of Queensland
2014-2025
Shanghai Academy of Environmental Sciences
2025
East China University of Science and Technology
2025
China Resources (China)
2024
Sichuan University
2024
West China Hospital of Sichuan University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Nanjing University of Chinese Medicine
2019-2024
Second Hospital of Shandong University
2019-2024
Silicosis has been topping the list of high-incidence occupational diseases in developing countries and cannot be completely cured. Recent advances stem cell research have made possible treatment various including lung fibrosis. The application therapy diseases, particular use adipose-derived mesenchymal cells (AD-MSCs) silicosis, not yet reported. aim study is to explore intervening effect silica-induced fibrosis rats. In this study, we investigated anti-pulmonary effects transplantation...
The breast cancer susceptibility gene 1 (BRCA1) is a major tumor suppressor and most frequently mutated in hereditary cancer. BRCA1 plays critical role many biological processes, especially maintaining genomic stability the nucleus, yet its cytoplasm remains elusive. Here, it revealed that maintains healthy mitochondrial network through regulating dynamics, including fission fusion. deficiency causes dysfunctional dynamics increased expression of mitofusin1/2. With stress, recruited to outer...
Long-term exposure to crystalline silica particles leads silicosis characterized by persistent inflammation and progressive fibrosis in the lung. So far, there is no specific treatment cure disease other than supportive care. In this study, we examined effects of metformin, a prescribed drug for type || diabetes on explored possible mechanisms an established rat model vivo , vitro co-cultured containing human macrophages cells (THP-1) bronchial epithelial (HBEC). Our results showed that...
Abstract Background Future distribution of dengue risk is usually predicted based on climate changes using general circulation models (GCMs). However, it difficult to validate the GCM results and assess uncertainty predictions. The observed in may be very different from results. We aim utilize trends dynamics predict future risks Aedes albopictus China. Methods collected Ae. surveillance data records 80 meteorological stations 1970 2021. analyzed change China made predictions for years 2050...
Gliomas are prevalent malignant tumors in adults, which can be categorized as either localized or diffuse gliomas. Glioblastoma is the most aggressive and deadliest form of glioma. Currently, there no complete cure, median survival time less than one year. The main mechanism regulated cell death involves organisms coordinating elimination damaged cells at risk tumor transformation hijacked by microorganisms for pathogen replication. This process includes apoptosis, necroptosis, autophagy,...
Atm gene-disrupted mice recapitulate the majority of characteristics observed in patients with genetic disorder ataxia-telangiectasia (A-T). However, although they exhibit defects neuromotor function and a distinct neurological phenotype, do not show progressive neurodegeneration seen human patients, but there is evidence that mutated (Atm)-deficient animals have elevated levels oxidized macromolecules some neuropathology. We report here vitro survival cerebellar Purkinje cells from both...
Accumulating evidence suggests that glioma stem cells (GSCs) are important therapeutic targets in glioblastoma (GBM). In this study, we identified NIMA-related kinase 2 (NEK2) as a functional binding protein of enhancer zeste homolog (EZH2) plays critical role the posttranslational regulation EZH2 GSCs. NEK2 was among most differentially expressed kinase-encoding genes GSC-containing cultures (glioma spheres), and it required for vitro clonogenicity, vivo tumor propagation, radioresistance....
Mulberry (Morus alba L.) leaf tea benefits the control of diabetes in Asian nations. This study was aim to investigate if flavonoids, which extracts from mulberry leaves, could regulate metabolism glycolipid, and flavonoids IRS1/PI3K/AKT pathway signal affect expression FAS membrane transfer capacity GLUT4 3T3-L1 adipocytes.Results revealed that decreased levels free fatty acid increased glucose consumption adiponectin leptin a dose-dependent manner, remarkably protein p-IRS1, p-PI3K, p-Akt,...
Silicon is one of the most widely used chemical materials, and increasing use silica nanoparticles (SNs) highlights requirement for safety biological toxicity studies. The damaging adverse effects SNs on human hepatocytes remain largely unknown, as do mechanisms involved. In present study, underlying SN‑induced in hepatocyte cell line HL‑7702 were investigated. An MTT assay revealed that following exposure to concentration range 25‑200 µg/ml, viability cells decreased, decreased further with...
Transforming growth factor-β 1 (TGF-β1) is a key mediator in fibrogenesis, and upregulated activated fibrotic diseases. The exact role of TGF-β1-Smad signaling the progression silicosis fibrosis yet to be conclusively determined. Using Wistar rat model, we examined whether tanshinone IIA (Tan IIA) could meliorate fibrosis. pulmonary fibroblasts rats from normal control group silicosis-induced model were extracted so as further explore disruption pathway pathogenesis intervention Tan this...
Atherosclerosis (AS) is exacerbated in the perimenopausal period, which significantly increases incidence rate of cardiovascular disease. The disruption gut microbiota has been associated with AS or menopause, but specific changes AS-associated period remain largely unknown. As lipid abnormalities are mainly responsible for AS, relationship between metabolism and disruptions during menopause rarely reported hitherto. In present study, ApoE-/- mice fed a high-fat diet (HFD) were subjected to...
Chromosome aberrations, genomic instability, and cancer predisposition are hallmarks of a number syndromes in which the defective genes recognize and/or repair DNA damage or involved some aspect processing. We report here direct interaction between BLM, mutated Bloom's Syndrome (BS), ATM, is ataxia-telangiectasia, we have mapped sites interaction. Full-length BLM cDNA corrected sister chromatid exchange (SCE) radiosensitivity BS cells. Mitotic phosphorylation was partially dependent on were...