A5037765902- Autophagy in Disease and Therapy
- Natural product bioactivities and synthesis
- Berberine and alkaloids research
- Bioactive Compounds and Antitumor Agents
- Sirtuins and Resveratrol in Medicine
- Receptor Mechanisms and Signaling
- Advances in Cucurbitaceae Research
- Nicotinic Acetylcholine Receptors Study
- Ginseng Biological Effects and Applications
- Fungal Biology and Applications
- Bioactive natural compounds
- Tryptophan and brain disorders
- Histone Deacetylase Inhibitors Research
- Phytochemistry and Biological Activities
- Cancer therapeutics and mechanisms
- Genomics, phytochemicals, and oxidative stress
- Metabolomics and Mass Spectrometry Studies
- Traditional Chinese Medicine Analysis
- Morinda citrifolia extract uses
- Hedgehog Signaling Pathway Studies
- Cardiac Ischemia and Reperfusion
- Cancer Treatment and Pharmacology
- Biological Activity of Diterpenoids and Biflavonoids
- Phytochemical Studies and Bioactivities
- Seaweed-derived Bioactive Compounds
University of Macau
2016-2025
Hainan University
2020-2025
City University of Macau
2020
Quality Research
2012-2013
Anhui Medical University
2013
Jinan University
2010
Alkaloids are important chemical compounds that serve as a rich reservoir for drug discovery. Several alkaloids isolated from natural herbs exhibit antiproliferation and antimetastasis effects on various types of cancers both in vitro vivo . Alkaloids, such camptothecin vinblastine, have already been successfully developed into anticancer drugs. This paper focuses the naturally derived with prospective properties, berberine, evodiamine, matrine, piperine, sanguinarine, tetrandrine,...
Most breast cancers at an advanced stage exhibit aggressive nature, and there is a lack of effective anticancer options. Herein, the development patient-derived organoids (PDOs) described as real-time platform to explore feasibility tailored treatment for refractory cancers. PDOs are successfully generated from cancer tissues, including heavily treated specimens. The microtubule-targeting drug-sensitive response signatures predict improved distant relapse-free survival invasive with adjuvant...
Berberine (BBR) is a renowned natural compound that exhibits potent neuroprotective activities. However, the cellular and molecular mechanisms are still unclear. Hormesis an adaptive mechanism generally activated by mild oxidative stress to protect cells from further damage. Many phytochemicals have been shown induce hormesis. This study aims investigate whether activity of BBR mediated hormesis related signaling pathways in 6-OHDA-induced PC12 zebrafish neurotoxic models. Our results...
Abstract Curcumin (CUR) and berberine (BBR) are renowned natural compounds that exhibit potent anticancer activities through distinct molecular mechanisms. However, the capacity of either CUR or BBR is limited. This prompted us to investigate chemopreventive potential co-treatment against breast cancers. The results showed in combination synergistically inhibited growth both MCF-7 MDA-MB-231 cancer cells than used alone. Further study confirmed synergistic anti-breast these two was inducing...
BRCA1 mutation carriers have a higher risk of developing triple-negative breast cancer (TNBC), which is refractory disease due to its non-responsiveness current clinical targeted therapies. Using the Sleeping Beauty transposon system in Brca1-deficient mice, we identified 169 putative drivers, among Notch1 top candidate for accelerating TNBC by promoting epithelial-mesenchymal transition (EMT) and regulating cell cycle. Activation NOTCH1 suppresses mitotic catastrophe caused deficiency...
The breast cancer susceptibility gene 1 (BRCA1) is a major tumor suppressor and most frequently mutated in hereditary cancer. BRCA1 plays critical role many biological processes, especially maintaining genomic stability the nucleus, yet its cytoplasm remains elusive. Here, it revealed that maintains healthy mitochondrial network through regulating dynamics, including fission fusion. deficiency causes dysfunctional dynamics increased expression of mitofusin1/2. With stress, recruited to outer...
Nasopharyngeal carcinoma (NPC) is a malignant head and neck cancer type with high morbidity in Southeast Asia, however the pathogenic mechanism of this disease poorly understood. Using integrative pharmacogenomics, we find that NPC subtypes maintain distinct molecular features, drug responsiveness, graded radiation sensitivity. The epithelial (EC) subtype characterized by activations microtubule polymerization defective mitotic spindle checkpoint related genes, whereas sarcomatoid (SC) mixed...
Quinones are plant-derived secondary metabolites that present some anti-proliferation and anti-metastasis effects in various cancer types both vitro vivo. This review focuses on the anti-cancer prospects of quinones, namely, aloe-emodin, juglone, β-lapachol, plumbagin, shikonin, thymoquinone. We intend to summarize their investigate mechanism actions promote research development agents from quinones. Keywords: Quinone, Plant, Secondary metabolites, Tumor
The aim of present study was to evaluate the effects Panax notoginseng saponins (PNS) against acute ethanol-induced liver injury and further elucidate its probable mechanisms. Mice were treated with PNS (100 or 300 mg/kg) once daily for seven consecutive days priors ethanol gavage (4.7 g/kg) every 12 h a total three doses. Acute alcohol dramatically significantly increased serum activities alanine aminotransferase (ALT) (23.4 ± 5.0 IU/L vs 11.7 4.1 IU/L) aspartate (AST) (52.6 14.9 31.1 12.9...
Cucurbitacins are a class of triterpenoids widely distributed in plant kingdom with potent anti-cancer activities both vitro and vivo by inducing cycle arrest, autophagy, apoptosis. Cucurbitacin B (Cuc B), could induce S or G2/M cell arrest cancer cells while the detailed mechanisms remain to be clear. This study was designed precisely dissect signaling pathway(s) responsible for Cuc induced human lung adenocarcinoma epithelial A549 cells. We demonstrated that low concentrations dramatically...
Abstract Hormesis is an adaptive response of living organisms to a moderate stress. However, its biomedical implication and molecular mechanisms remain be intensively investigated. Panaxatriol saponins (PTS) the major bioactive components extracted from Panax notoginseng , widely used herbal medicine for cerebrovascular diseases. This study aims examine hormetic neuroprotective effects PTS in PC12 cells zebrafish Parkinson’s disease (PD) models. Our results demonstrated that stimulated cell...
Polyphyllin VII (PP7), a pennogenyl saponin isolated from Rhizoma Paridis, exhibited strong anticancer activities in various cancer types. Previous studies found that PP7 induced apoptotic cell death human hepatoblastoma (HepG2) cells. In the present study, we investigated whether could induce autophagy and its role PP7-induced death, elucidated mechanisms. robust HepG2 cells as demonstrated by conversion of LC3B-I to LC3B-II, degradation P62, formation punctate LC3-positive structures,...
Forsythiae Fructus, the fruits of Forsythia suspensa (Thunb.) Vahl, Lianqiao in Chinese, is one most fundamental herbs traditional Chinese medicine (TCM). It a typical heat-clearing and detoxicating herb, according to TCM theory. In this study, we investigated antitumor effect Fructus aqueous extract (FAE) on B16-F10 melanoma cells vivo. The transplanted C57BL/6 mice was established used for evaluation vivo FAE. FAE strongly inhibited growth vitro tumor survival time tumor-bearing...
Hormesis is a phenomenon of biphasic dose response characterized by exhibiting stimulatory or beneficial effects at low doses and inhibitory toxic high doses. Increasing numbers chemicals various types have been shown to induce apparent hormetic effect on cancer cells. However, the underlying significance mechanisms remain be elucidated. Berberine, one major active components Rhizoma coptidis, has manifested with notable anticancer activities. This study aims investigate berberine its...
Ganoderma lucidum (Fr.) Karst is a traditional Chinese herb that has been widely used for centuries to treat various diseases including cancer. Herein, an ethanol-soluble and acidic component (ESAC), which mainly contains triterpenes, was prepared from G. its anti-tumor effects in vitro were tested on human breast cancer cells. Our results showed ESAC reduced the cell viability of MCF-7 MDA-MB-231 cells concentration-dependent manner with IC 50 about 100 μg/mL 60 μg/mL, respectively. DNA...