A5022347711- Ginseng Biological Effects and Applications
- Natural product bioactivities and synthesis
- Fatty Acid Research and Health
- Polysaccharides and Plant Cell Walls
- Phytochemicals and Antioxidant Activities
- Metabolomics and Mass Spectrometry Studies
- Phytochemistry and Biological Activities
- Autophagy in Disease and Therapy
- Berberine and alkaloids research
- Pharmacological Effects of Natural Compounds
- Liver Disease Diagnosis and Treatment
- Eicosanoids and Hypertension Pharmacology
- RNA Interference and Gene Delivery
- Genomics, phytochemicals, and oxidative stress
- Gastrointestinal motility and disorders
- Traditional Chinese Medicine Analysis
- Analytical Chemistry and Chromatography
- Gut microbiota and health
- RNA modifications and cancer
- Alcohol Consumption and Health Effects
- Cancer therapeutics and mechanisms
- Curcumin's Biomedical Applications
- Nanoparticle-Based Drug Delivery
- Rheumatoid Arthritis Research and Therapies
- Diet and metabolism studies
University of Macau
2016-2025
Capital Medical University
2022-2024
Xiangtan University
2024
Capital University
2022-2023
Quality Research
2016-2022
Nanjing Medical University
2022
Shanghai Customs College
2021
China Academy of Chinese Medical Sciences
2014-2019
Jinan University
2016
Macao Polytechnic University
2015-2016
Label-free chemical contrast is highly desirable in biomedical imaging. Spontaneous Raman microscopy provides specific vibrational signatures of bonds, but often hindered by low sensitivity. Here we report a three-dimensional multiphoton imaging technique based on stimulated scattering (SRS). The sensitivity SRS significantly greater than that spontaneous microscopy, which achieved implementing high-frequency (megahertz) phase-sensitive detection. has major advantage over previous coherent...
Docosahexaenoic acid (DHA), an n-3 long chain polyunsaturated fatty (LC-PUFA), highly enriched in the central nervous system, is critical for brain development and function. It has been shown that DHA deficiency impairs cognitive performance whereas supplementation improves condition. However, mechanisms underlying role of function remain to be elucidated. By using transgenic fat-1 mice rich endogenous PUFA, we show increased significantly enhances hippocampal neurogenesis by number...
Berberine (BBR) is a renowned natural compound that exhibits potent neuroprotective activities. However, the cellular and molecular mechanisms are still unclear. Hormesis an adaptive mechanism generally activated by mild oxidative stress to protect cells from further damage. Many phytochemicals have been shown induce hormesis. This study aims investigate whether activity of BBR mediated hormesis related signaling pathways in 6-OHDA-induced PC12 zebrafish neurotoxic models. Our results...
The development of cardiac hypertrophy in response to increased hemodynamic load and neurohormonal stress is initially a compensatory that may eventually lead ventricular dilation heart failure. Regulator G protein signaling 5 (Rgs5) negative regulator protein-mediated by inactivating Gα(q) Gα(i), which mediate actions most known vasoconstrictors. Previous studies have demonstrated Rgs5 expresses among various cell types within mature showed high levels mRNA monkey human tissue Northern blot...
Curcumin, a natural chemical compound found in Curcuma longa , has been applied multiple medicinal areas from antibiotic to antitumor treatment. However, the structure of curcumin results poor stability, low solubility, and rapid degradation vivo hindering its clinical utilization. To address these issues, we have developed novel niosome system composed nonionic surfactants: Span 80, Tween Poloxamer 188. Curcumin was encapsulated niosomes with high entrapment efficiency <mml:math...
Abstract Curcumin (CUR) and berberine (BBR) are renowned natural compounds that exhibit potent anticancer activities through distinct molecular mechanisms. However, the capacity of either CUR or BBR is limited. This prompted us to investigate chemopreventive potential co-treatment against breast cancers. The results showed in combination synergistically inhibited growth both MCF-7 MDA-MB-231 cancer cells than used alone. Further study confirmed synergistic anti-breast these two was inducing...
An important nutritional question as to whether the ratio of omega-6 (n-6) omega-3 (n-3) fatty acids plays a role in tumorigenesis remains be clarified well qualified experimental models. The recently engineered fat-1 mice, which can convert n-6 n-3 and have balanced their tissues organs independent diet, allow carefully controlled studies performed absence potential confounding factors diet therefore are useful model for elucidating n-6/n-3 acid tumorigenesis. We implanted mouse melanoma...
Chromatin remodeling, particularly histone acetylation, plays a critical role in the progression of pathological cardiac hypertrophy and heart failure. We hypothesized that curcumin, natural polyphenolic compound abundant spice turmeric known suppressor would suppress through disruption p300 acetyltransferase-dependent (p300-HAT-dependent) transcriptional activation. tested this hypothesis using primary cultured rat myocytes fibroblasts as well two well-established mouse models hypertrophy....
Abstract One of the promising strategies to overcome tumor multidrug resistance (MDR) is deliver anticancer drug along with P-glycoprotein (P-gp) inhibitor simultaneously. To enhance cancer cellular internalization and implement controlled release, herein an iRGD peptide-modified lipid-polymer hybrid nanosystem (LPN) was fabricated coload paclitaxel (PTX) tetrandrine (TET) at a precise combination ratio. In this co-delivery system, PTX covalently conjugated poly ( D,L -lactide-co-glycolide)...