A5030441371- Viral gastroenteritis research and epidemiology
- Flavonoids in Medical Research
- Gut microbiota and health
- Polysaccharides and Plant Cell Walls
- Influenza Virus Research Studies
- Infant Nutrition and Health
- Phytochemicals and Antioxidant Activities
- Seaweed-derived Bioactive Compounds
- Animal Disease Management and Epidemiology
- Pharmacological Effects of Natural Compounds
- Fungal Biology and Applications
- Metabolomics and Mass Spectrometry Studies
- Natural product bioactivities and synthesis
- Animal Virus Infections Studies
- Genomics, phytochemicals, and oxidative stress
- Natural Antidiabetic Agents Studies
- Glycosylation and Glycoproteins Research
- Algal biology and biofuel production
- Phytochemistry and Biological Activities
- Apelin-related biomedical research
- Clusterin in disease pathology
- Bone Metabolism and Diseases
- Medicinal Plants and Bioactive Compounds
- Diet, Metabolism, and Disease
- IgG4-Related and Inflammatory Diseases
University of Macau
2022-2025
Fujian Agriculture and Forestry University
2019-2022
City University of Macau
2022
Ministry of Education
2021
South China Agricultural University
2016-2020
Key Laboratory of Guangdong Province
2019-2020
Shantou University
2020
Shantou University Medical College
2020
Guangdong Academy of Agricultural Sciences
2016
University of Pisa
2013
A bioactive polysaccharide from microalga Chlorella pyrenoidosa (CPP) was successively prepared via DEAE-52 and G-100 columns. Nuclear magnetic resonance analysis showed that the main glycosidic bonds were composed of 1,2-linked-α-l-Fucp, 1,4-linked-α-l-Rhap, 1,4-linked-β-l-Araf, 1-linked-α-d-Glcp, 1,3-linked-β-d-GlcpA, 1,4-linked-β-d-Xylp, 1,3,6-linked-β-d-Manp. Its molecular weight 5.63 × 106 Da. The hypolipidemic effect intestinal flora regulation CPP on diet-induced rats evaluated...
Dietary flavonoids are abundant in natural plants and possess multiple pharmacological nutritional activities. In this study, apigenin, luteolin, baicalein were chosen to evaluate their anti-diabetic effect high-glucose dexamethasone induced insulin-resistant (IR) HepG2 cells. All improves the glucose consumption glycogen synthesis abilities IR-HepG2 cells via activating transporter protein 4 (GLUT4) phosphor-glycogen synthase kinase (GSK-3β). These significantly inhibited production of...
Fisetin (Fis), quercetin (Que), and myricetin (Myr) are flavonols with similar structure but different number of hydroxyl groups. The present research focused on the anti-inflammatory effect these three in lipopolysaccharide-stimulated RAW264.7 cells. site group obviously affected their anti-inflammation activity. These suppressed overproduction nitric oxide. Fis showed best activity an inhibition rate 52% at 20 μM. Moreover, reduced levels ROS, TNF-α, IL-6. mechanistic study that they...
Abstract Fisetin is one of the most popular flavonoids found in vegetables and fruits with several health benefits such as antidiabetic, anticancer, anti‐inflammatory activities. Biotechnology or chemosynthesis tools were used for synthesis fisetin its analogs to improve their yield efficacy. Structure activity relationships (SARs) revealed that aromatic hydroxyl groups especially 3,4‐dihydroxylation at ring B crucial biological activities, whereas substitution appeared impact original...
Many delicious and nutritional macrofungi are widely distributed used in East Asian regions, considered as edible medicinal foods. In this study, 11 species of dried fresh, macrofungi, Ganoderma amboinense, Agaricus subrufescens, Dictyophora indusiata, Pleurotus sajor-caju, ostreatus, geesteranu, Hericium erinaceus, Stropharia rugosoannulata, sapidus, Antrodia camphorata, Lentinus edodes (Berk.) Sing, were investigated to determine the content their components, including proteins, fat,...
This research aimed to investigate the antidiabetic activity, underlying mechanisms, and gut microbiota regulation of aloin. The insulin-resistant HepG2 (IR-HepG2) cell model type 2 diabetic (T2D) mouse were successfully established using dexamethasone a high-fat high-sucrose diet with low-dose streptozotocin, respectively. Aloin intervention increased glucose consumption stimulated activity hexokinase pyruvate dehydrogenase in IR-HepG2 cells. Additionally, it diminished weight loss, reduced...
The therapeutic efficacy of osimertinib (OSI) in EGFR-mutant lung cancer is ultimately limited by the onset acquired resistance, which mechanisms remain poorly understood. Here, we identify a novel long non-coding RNA, LRTOR, as key driver OSI resistance non-small cell (NSCLC). Clinical data indicate that elevated LRTOR expression correlates with poor prognosis OSI-resistant patients. Functionally, promotes tumor growth and confers both vitro vivo. Mechanistically, shields YAP from...
Nowadays, there have been major demographic shifts in China and India. In this context, it is crucial to conduct research on the problems shortcomings faced by India their current development, order allow two countries better planning for development strategies forming policies. This article first examines differences population structure between study then compares from four aspects, including economic model, social security challenge, education human capital, international relations global...
The Eurasian avian-like swine (EA) H1N1 virus has affected the Chinese industry, and human infection cases have been reported occasionally. However, little is known about pathogenic mechanism of EA virus. In this study, we compared mouse pathogenicity A/swine/Guangdong/YJ4/2014 (YJ4) A/swine/Guangdong/MS285/2017 (MS285) viruses, which had similar genotype to A/Hunan/42443/2015 (HuN-like). None mice inoculated with 106 TCID50 YJ4 survived at 7 days post infection, while survival rate MS285...
Porcine reproductive and respiratory syndrome virus (PRRSV) is a huge threat to the modern pig industry, current vaccine prevention strategies could not provide full protection against it. Therefore, exploring new anti-PRRSV urgently needed. Ginsenoside Rg1, derived from ginseng notoginseng, shown exert anti-inflammatory, neuronal apoptosis-suppressing anti-oxidant effects. Here we demonstrate Rg1-inhibited PRRSV infection both in Marc-145 cells porcine alveolar macrophages (PAMs)...
To study the metabolic effects of insulin derived from islet grafts, oral glucose tolerance (OGT) and turnover were examined in streptozotocin-induced diabetic Lewis rats rendered normoglycemic by syngeneic grafts renal subcapsular space (REN), REN with vein-to-mesenteric vein anastomosis (REN-RMA), liver (intrahepatic [IH]), or a parahepatic omental pouch (POP) compared normal rats. Normal OGT was found at 1 month posttransplant all animals receiving approximately 3,000 islets,...
Fucosylated oligosaccharides have important biological functions as well an excellent antiviral activity. A novel
A novel bacterial α 1–2-fucosyltransferase (α 2FT) from Thermosynechococcus sp. NK55a (Ts2FT) has been discovered and characterized. It shares 28–62% protein sequence homology to 2FTs reported previously. The Ts2FT was cloned as an N-terminal His6-tagged recombinant (His6-Ts2FT) expressed in E. coli BL21 (DE3). at a level of 6.2 mg/L culture after induction with 0.05 mM isopropylβ-d-1-thiogalactoside (IPTG) 16 °C for 20 h. showed the optimal activity reaction temperature 40 pH 7.0. presence...
Infection with a novel H10N8 influenza virus in humans was first described China December 2013, which raised concerns related to public health. This subsequently confirmed have originated from live poultry market. However, whether this can infect other mammals remains unclear. In the present study, antibody specific for detected swine herds southern during serological monitoring virus. The pathogenicity and transmissibility of examined. results showed that are susceptible infection...