A5051160593- Natural product bioactivities and synthesis
- Pharmacological Effects of Natural Compounds
- Rheumatoid Arthritis Research and Therapies
- Traditional Chinese Medicine Analysis
- Phytochemistry and Biological Activities
- Nanoplatforms for cancer theranostics
- Neuroinflammation and Neurodegeneration Mechanisms
- Natural Compounds in Disease Treatment
- NF-κB Signaling Pathways
- Advanced Nanomaterials in Catalysis
- Immune cells in cancer
- Cytokine Signaling Pathways and Interactions
- Extracellular vesicles in disease
- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Ginseng Biological Effects and Applications
- Neurological Disease Mechanisms and Treatments
- Medicinal Plant Pharmacodynamics Research
- Inflammatory Bowel Disease
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Genomics, phytochemicals, and oxidative stress
- Toxin Mechanisms and Immunotoxins
- Bone Metabolism and Diseases
- MicroRNA in disease regulation
- Infant Nutrition and Health
University of Macau
2016-2025
Hong Kong Baptist University
2013-2025
Wenzhou Medical University
2025
First Affiliated Hospital of Wenzhou Medical University
2025
SUNY Downstate Health Sciences University
2012-2025
Celltrion (South Korea)
2025
Nankai University
2005-2024
Guiyang Medical University
2024
Taizhou University
2024
Zhejiang Center for Disease Control and Prevention
2022
Abstract Here an excellent trimodality imaging‐guided synergistic photothermal therapy (PTT)/photodynamic (PDT)/chemodynamic (CDT) is proposed. To this end, a mixed‐metal Cu/Zn‐metal‐organic framework (MOF) first assembled at room temperature on nano‐scale. Interestingly, heating the MOF results in Cu +/2+ ‐coexisting hollow porous structure. Subsequent treatment used to integrate Mn 2+ and MnO 2 presence of manganese(II) acetylacetonate. The composite achieves efficient loading...
Direct brain biopsy is rarely indicated during acute stroke. This study uses peripheral blood mononuclear cells (PBMCs) to determine whether a systemic gene expression profile could be demonstrated in patients with ischemic stroke.Using oligonucleotide microarrays, we compared the of an index cohort 20 confirmed stroke on neuroimaging studies that referent subjects. Validation used quantitative real-time polymerase chain reaction measure levels 9 upregulated genes cohort, and independent 10...
Compound Danshen Formula (CDF) is a widely used Traditional Chinese Medicine (TCM) which has been extensively applied in clinical treatment of cardiovascular diseases (CVDs). However, the underlying mechanism administrating CDF on CVDs not clear. In this study, pharmacological effect was analyzed at systemic point view. A systems-pharmacological model based chemical, chemogenomics and data developed via network reconstruction approach. By using model, we performed high-throughput silico...
Signal transducer and activator of transcription 3 (STAT3) signaling is constantly activated in human melanoma, promotes melanoma metastasis. The dietary flavonoid apigenin a bioactive compound that possesses low toxicity exerts anti-metastatic activity melanoma. However, the anti-metastasis mechanism has not been fully elucidated. In present study, we showed suppressed murine B16F10 cell lung metastasis mice, inhibited migration invasion cells. Further study indicated effectively STAT3...
Melanoma is notorious for its propensity to metastasize, which makes treatment extremely difficult. Receptor tyrosine kinase c-Met activated in human melanoma and involved progression metastasis. Hepatocyte growth factor (HGF)-mediated activation of signaling has been suggested as a therapeutic target Quercetin dietary flavonoid that exerts anti-metastatic effect various types cancer including melanoma. In previous report, we demonstrated quercetin inhibited cell migration invasion vitro,...
Herein, we revealed the factors that affect emission in mixed-ligand metal-organic frameworks (MOFs) with combination of terephthalic acid (BDC), 2-aminoterephthalic (BDC-NH2), and 2,5-dihydroxylterephthalic [BDC-(OH)2] as models. The -NH2 -(OH)2 groups change π-conjugation luminescence behaviors than BDC, so ligands show different optical behaviors. Zn2+ ion a 3d10 full electronic structure shows little effect on ligand is selected metal node. We found BDC weak incompatible to BDC-NH2, only...
Rheumatoid arthritis (RA) is an inflammatory disease accompanied by abnormal synovial microenvironment (SM). Sesquiterpene lactones (SLs) are the main anti-inflammatory ingredients of many traditional herbs utilized in RA treatment.
Reactive oxygen species (ROS)-involved photodynamic therapy (PDT) and chemodynamic (CDT) hold great promise for tumor treatment. However, hypoxia, insufficient H2O2, overexpressed glutathione (GSH) in the microenvironment (TME) hinder ROS generation significantly. Herein, we reported CaO2@Cu-TCPP/CUR with O2/H2O2/Ca2+ self-supply GSH depletion enhanced PDT/CDT Ca2+ overload synergistic therapy. CaO2 nanospheres were first prepared used as templates guiding coordination between carboxyl of...
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by bone erosion and cartilage destruction in the joints. Many of conventional antiarthritic drugs are effective suppressing inflammation, but they do not offer protection against damage. Furthermore, prolonged use these associated with severe adverse reactions. Thus, new therapeutic agents that can control both inflammation damage minimal side effects sought. Celastrus Chinese herb has been used for centuries folk...
Pluronic F127 (F127), an amphiphilic triblock copolymer, has been shown to have significant potential for drug delivery, as it is able incorporate hydrophobic drugs and self-assemble into nanosize micelles. However, suffers from dissociation upon dilution owing the relatively high critical micelle concentration lack of stimuli-responsive behavior. Here, we synthesized α-tocopherol (TOC) modified polymer (F127-SS-TOC) via a redox-sensitive disulfide bond between TOC, which formed stable...