A5055687379- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Natural Compounds in Disease Treatment
- Graphene and Nanomaterials Applications
- Biological Activity of Diterpenoids and Biflavonoids
- Curcumin's Biomedical Applications
- Eating Disorders and Behaviors
- Obsessive-Compulsive Spectrum Disorders
- Reliability and Maintenance Optimization
- Optical Systems and Laser Technology
- Sustainable Supply Chain Management
- Electronic Packaging and Soldering Technologies
- Microfluidic and Capillary Electrophoresis Applications
- Energy, Environment, Economic Growth
- Grey System Theory Applications
- Retinoids in leukemia and cellular processes
- Hydrogels: synthesis, properties, applications
- Neuroscience of respiration and sleep
- Breastfeeding Practices and Influences
- Environmental Sustainability in Business
- Advanced Measurement and Detection Methods
- Ginger and Zingiberaceae research
- Advanced Polymer Synthesis and Characterization
- Electromagnetic Launch and Propulsion Technology
- Autophagy in Disease and Therapy
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2024
Hebei Medical University
2024
Second Hospital of Hebei Medical University
2024
China Academy of Chinese Medical Sciences
2019-2022
Nanjing University
2022
Jiangsu University of Science and Technology
2016-2017
Institute of Immunology
1999
Pluronic F127 (F127), an amphiphilic triblock copolymer, has been shown to have significant potential for drug delivery, as it is able incorporate hydrophobic drugs and self-assemble into nanosize micelles. However, suffers from dissociation upon dilution owing the relatively high critical micelle concentration lack of stimuli-responsive behavior. Here, we synthesized α-tocopherol (TOC) modified polymer (F127-SS-TOC) via a redox-sensitive disulfide bond between TOC, which formed stable...
Emodin is the main component of traditional Chinese medicines including rhubarb, Polygonum multiflorum, and cuspidatum. It has confirmed hepatotoxicity may be causative agent liver damage associated with above-mentioned medicines. However, current research does not explain mechanism emodin in hepatotoxicity. In this study, L02 cells were used as a model to study emodin-induced hepatocyte apoptosis using quantitative proteomics, results verified by Western blot. A total 662 differentially...
Purpose Grounded in inter-firm collaboration contexts, this study examines the influence of technological relatedness – encompassing similarity and complementarity on innovation performance manufacturing enterprises emerging economies, with a focus how environmental dynamism, competitiveness firm life cycle stages moderate these relationships. Design/methodology/approach The authors empirically tested hypotheses based data Chinese listed companies from 2006 to 2021. Findings Both positively...
Space relays are affected by many nonlinear elements during storage, and the reason for predicting time series is to achieve mapping. Combining artificial neural networks grey system theory, we built a network (GANN) model. The model effectively combined characteristics of artificial-neural-network adaptability theory weakening data sequence volatility integration. We predicted degradation value closing measured in relay accelerated storage test using variety models GANN models. By comparing...
The preparation processes of iron-based organic framework(FeMOF) MIL-100(Fe) and MIL-101(Fe) with two different ligands were optimized screened, the FeMOF was loaded piperlongumine(PL) to enhance biocompatibility antitumor efficacy PL. prepared by solvent thermal method using reaction solvent. With particle size, polymer dispersity index(PDI), yield as indexes, optimal obtained definitive screening design(DSD) experiment establishing a mathematical model, combined Derringer expectation...
Celastrol (CEL) is one of the main effective components traditional Chinese medicine Tripterygium wilfordii Hook.f, which has high antitumor activity. However, its low solubility and bioavailability limit clinical use. In this study, CEL nanosuspension with near-infrared photothermal properties (PDA@CEL-NS) was prepared. PDA@CEL-NS a kind spherical nanoparticles an average particle size 189.67 nm, potential - 30.23 mV drug loading 60.33%. X-ray diffraction showed that it amorphous structure....
Abstract Background In today's society, with the sustainable development of economy, material products are rich and diverse. The production speed has far exceeded people's needs. Emission reduction environmental protection have become new pursuit. Closed loop supply chain should consider not only product life cycle recycling, but also economic benefits. It focus scholars all over world. refers to complete from procurement final sales, including recovery reverse logistics supported by cycle....