A5064772022- Malaria Research and Control
- Synthesis and Catalytic Reactions
- Thyroid Cancer Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Cancer therapeutics and mechanisms
- Traditional and Medicinal Uses of Annonaceae
- Cancer Diagnosis and Treatment
- Trypanosoma species research and implications
- NF-κB Signaling Pathways
- Radiomics and Machine Learning in Medical Imaging
- Computational Drug Discovery Methods
- DNA and Nucleic Acid Chemistry
- Plant Toxicity and Pharmacological Properties
- Immune Response and Inflammation
- Molecular spectroscopy and chirality
- Synthesis and biological activity
- linguistics and terminology studies
- Electron Spin Resonance Studies
- Advanced Breast Cancer Therapies
- Neuroendocrine Tumor Research Advances
- Biomedical Text Mining and Ontologies
- Macrophage Migration Inhibitory Factor
- Natural product bioactivities and synthesis
- Pancreatic and Hepatic Oncology Research
- Estrogen and related hormone effects
Suizhou Central Hospital
2022-2025
Guiyang Medical University
2024
Affiliated Hospital of Guizhou Medical University
2024
Johns Hopkins University
1994-1998
Johns Hopkins Medicine
1998
Weizmann Institute of Science
1996
Walter Reed Army Institute of Research
1994
University of Michigan
1994
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMechanism-Based Design, Synthesis, and in vitro Antimalarial Testing of New 4-Methylated Trioxanes Structurally Related to Artemisinin: The Importance a Carbon-Centered Radical for ActivityGary H. Posner, Chang Ho Oh, Dasong Wang, Lucia Gerena, Wilbur K. Milhous, Steven R. Meshnick, Wanida AsawamahasadkaCite this: J. Med. Chem. 1994, 37, 9, 1256–1258Publication Date (Print):April 1, 1994Publication History Published online1 May 2002Published...
Rheumatoid arthritis (RA) is an inflammatory disease accompanied by abnormal synovial microenvironment (SM). Sesquiterpene lactones (SLs) are the main anti-inflammatory ingredients of many traditional herbs utilized in RA treatment.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFurther Evidence Supporting the Importance of and Restrictions on a Carbon-Centered Radical for High Antimalarial Activity 1,2,4-Trioxanes Like ArtemisininGary H. Posner, Dasong Wang, Jared N. Cumming, Chang Ho Oh, Andrew French, Annette L. Bodley, Theresa A. ShapiroCite this: J. Med. Chem. 1995, 38, 13, 2273–2275Publication Date (Print):June 1, 1995Publication History Published online1 May 2002Published inissue 1 June...
Background Precise recognition of neck lymph node metastasis (LNM) is essential for choosing the suitable scope operation papillary thyroid cancer(PTC) patients. Objective The purpose our study was to establish an effective nomogram integrating both gene biomarkers and clinicopathologic features preoperatively predicting LNM in PTC Methods We gathered clinical information expression data samples from Cancer Genome Atlas database (TCGA). WGCNA differential analysis were applied identify...
ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTEvidence for the Importance of High-Valent FeO and a Diketone in Molecular Mechanism Action Antimalarial Trioxane Analogs ArtemisininGary H. Posner, Sheldon B. Park, Lluïsa González, Dasong Wang, Jared N. Cumming, Donna Klinedinst, Theresa A. Shapiro, Mario D. BachiView Author Information Department Chemistry, School Arts Sciences, The Johns Hopkins University Baltimore, Maryland 21218 Medicine, Medicine 21205 Organic Chemistry Weizmann...
Novel C4-(hydroxyalkyl)trioxanes 5d and 5e were designed synthesized based on an understanding of the molecular mechanism action similar 1,2,4-trioxanes structurally related to antimalarial natural product artemisinin (1). In vitro efficacies these two new pairs C4-diastereomers against chloroquine-sensitive Plasmodium falciparum support conclusions about importance activity formation a C4 radical by 1,5-hydrogen atom abstraction. Derivatives 6, 7, 21 C4β-substituted trioxane alcohols 4a,...
A series of tetracyclic and tricyclic trioxane dimers has been prepared with ether ester tethers varying length flexibility. Several these have found to potent potentially therapeutically valuable antimalarial, antiproliferative, antitumor activities in vitro.
Purpose This investigation leveraged the SEER database to delve into progression patterns of PTC when left untreated. Furthermore, it aimed devise and authenticate a nomogram for prognosis prediction such patients. Methods We extracted data from database, focusing on PTC-diagnosed individuals 2004-2020. To discern disease intervals, median survival times across stages were gauged, time was estimated by subtracting more severe stage its preceding stage. Prognostic determinants in training set...
This study aimed to develop and validate a prognostic model for elderly patients with differentiated thyroid carcinoma (DTC) based on various demographic clinical parameters in order accurately predict patient outcomes. Patients who were diagnosed DTC over 55 years old between 2010 2019 identified from the Surveillance, Epidemiology, End Results database. The then randomly divided into training set validation 7:3 ratio, our center included as an external group. Univariate multivariate Cox...
The main purpose of this study was to build a prediction model for male breast cancer (MBC) patients predict the possibility distant metastasis. Surveillance, Epidemiology, and End Results database used obtain data on with MBC. were divided into training set validation at ratio 7:3. risk variables metastasis in determined by univariate multivariate logistic regression analyses. And then we integrated those factors construct nomogram. nomogram further verified verification set. discrimination...
Abstract A series of rules has been developed, using mainly 1D and 2D NMR spectroscopy, for identification relative stereochemistry in a variety substituted antimalarial 1,2,4-trioxanes.
Abstract The embryonic development of the pancreas originates from dorsal and ventral anlagen, pancreatic cancer arising or may have different clinical pathology features. This study aims to explore whether there are differences in clinicopathological features prognosis head carcinoma pancreas. Between January 2014 February 2018, 101 patients with resectable who underwent pancreaticoduodenectomy our institution were retrospectively reviewed. assigned into 2 groups according tumor location on...
Background Breast cancer endocrine therapy research has become a crucial domain in oncology since hormone receptor-positive breast cancers have been increasingly recognized, and targeted therapeutic interventions advancing over the past few years. This bibliometric analysis attempts to shed light on trends, dynamics, knowledge hotspots that shaped landscape of between 2003 2022. Methods In this study, we comprehensively reviewed scientific literature spanning above-mentioned period, which...
Abstract Purpose : The primary aim of this study was to explore the natural history breast cancer in absence treatment, aiming identify main factors affecting prognosis untreated patients. Methods Data for patients diagnosed with invasive between 2010 and 2020 were obtained from SEER database. disease progression time estimated by subtracting median survival higher stages that lower stages. Untreated divided into a training set validation 7:3 ratio. In set, independent risk identified...