A5101479493- Parasites and Host Interactions
- Fungal Biology and Applications
- Cancer-related Molecular Pathways
- Immune Response and Inflammation
- Infection Control in Healthcare
- Animal Disease Management and Epidemiology
- Cancer-related molecular mechanisms research
- Ubiquitin and proteasome pathways
- Parasite Biology and Host Interactions
- Psoriasis: Treatment and Pathogenesis
- Immune cells in cancer
- Workplace Violence and Bullying
- Cancer, Hypoxia, and Metabolism
- Echinoderm biology and ecology
- Infection Control and Ventilation
- Bone Tissue Engineering Materials
- Security in Wireless Sensor Networks
- Virus-based gene therapy research
- interferon and immune responses
- Vector-Borne Animal Diseases
- Tissue Engineering and Regenerative Medicine
- Hippo pathway signaling and YAP/TAZ
- Trypanosoma species research and implications
- Occupational Health and Safety Research
- Oral Health Pathology and Treatment
Sun Yat-sen University
2018-2025
Fifth Affiliated Hospital of Sun Yat-sen University
2025
Chongqing Medical University
2024
Sun Yat-sen University Cancer Center
2022-2024
China Animal Health and Epidemiology Center
2024
Nanjing Medical University
2011-2023
Xinqiao Hospital
2023
Army Medical University
2023
Shanghai Jiao Tong University
2010-2023
Shanghai Children's Medical Center
2014-2023
Hepatocyte apoptosis, a well-defined form of cell death in non-alcoholic steatohepatitis (NASH), is considered the primary cause liver inflammation and fibrosis. However, mechanisms underlying regulation hepatocyte apoptosis NASH remain largely unclear. We explored anti-apoptotic effect CD1d NASH.
Background The current knowledge of immunological responses to schistosomiasis, a major tropical helminthic disease, is insufficient, and better understanding these would support vaccine development or therapies control granuloma-associated immunopathology. CD4+ T cells play critical roles in both host immune against parasitic infection immunopathology schistosomiasis. induction helper (Th)1, Th2 regulatory (Treg) their schistosome infections are well-illustrated. However, little vivo data...
The therapeutic efficacy of osimertinib (OSI) in EGFR-mutant lung cancer is ultimately limited by the onset acquired resistance, which mechanisms remain poorly understood. Here, we identify a novel long non-coding RNA, LRTOR, as key driver OSI resistance non-small cell (NSCLC). Clinical data indicate that elevated LRTOR expression correlates with poor prognosis OSI-resistant patients. Functionally, promotes tumor growth and confers both vitro vivo. Mechanistically, shields YAP from...
Literature about healthcare-associated infection (HCAI) in China is scarce. A cross-sectional anonymous survey was conducted on 647 clinicians (199 physicians and 448 nurses) from six Shanghai hospitals (grades A–C) to investigate their cognizance, knowledge, attitude, self-reported practice, risks regarding HCAI with emphasis precautions. The mean overall score of knowledge 40.89±11.4 (mean±SD; range, 13∼72) out 100 for 43.48±9.9 (10∼70) nurses. respondents generally received high scores...
Abstract Sepsis is a life-threatening organ dysfunction caused by dysregulated host response to infection. Macrophages play important roles in the inflammatory process of sepsis secreting chemokines. Chemokine (CC-motif) ligand 2 (CCL-2) one main pro-inflammatory chemokines secreted macrophages that plays critical role recruitment more monocytes and sites injury sepsis, but mechanisms regulate CCL-2 expression during are still unknown. In present study, using lipopolysaccharide (LPS)-induced...
Senecaviurs A (SVA) infection, an emerging infectious disease in pig populations, is characterized by vesicular lesions predominantly affecting the mouth, snout, and hooves of infected pigs, similar to symptoms Foot Mouth Disease Virus (FMDV). This first spread into China 2015, causing great panic breeding industry. To determine prevalence SVA herds from 2018 2021, a total 4,901 tissue samples were collected 18 provinces, autonomous regions municipalities (P.A.M.s) for epidemiological...
Sink mobility has attracted much research interests in Wireless Sensor Networks (WSNs), because it could provide energy saving and reduce latency during data collection. However, the mobile sink node is still a single point of failure many WSNs applications, thus needs to be particularly protected against adversaries. We propose this paper moving strategy for which prevents tracking or detecting on by adversaries its collection phase around sensor field. Our aims selecting trajectory node,...
Human-treated dentin matrix (hTDM) has recently been studied as a natural extracellular matrix-based biomaterial for pulp regeneration. However, porcine-treated (pTDM) is potential alternative scaffold due to limited availability. there dearth of information regarding the protein composition and underlying molecular mechanisms pTDM.Methods: hTDM pTDM were fabricated using human porcine teeth, respectively, their morphological characteristics examined scanning electron microscopy. Stem cells...
Peroxisome proliferator-activated receptor alpha (PPARA) has been suggested as a therapeutic target for chronic lymphocytic leukemia (CLL). However, the underlying molecular mechanism remains largely unclear. In this study, we analyzed DNA next-generation sequencing (NGS) data and clinical information from 86 CLL patients to identify gene markers related treatment-free survival (TFS) length. We then constructed genetic network that includes promoters, treatment targets, TFS-related marker...
Abstract This study investigates advanced colorectal cancer (CRC), focusing on its tendency for distant metastasis and chemotherapy resistance. It highlights the importance of PANoptosis, a cell death pathway, role Receptor-interacting serine/threonine-protein kinase (RIPK) family in tumor progression. RIPK4’s tissue-specific functions behavior are emphasized, including influence invasion, migration, oxidative stress The reveals critical balance reactive oxygen species (ROS) cells, linked to...
This study aimed to investigate the effect of different environmental disinfection methods on reducing contaminated surfaces (CSs) by Omicron BA.2.2 variant SARS-CoV-2 in fever clinic between March 20 and May 30, 2022, analyze influences related factors CSs. includes survey data from 389 positive patients (SPPs) 204 CSs clinic, including CS type, method, length time spent cycle threshold (CT) value, name, age, weight, mask mask-wearing compliance, hand-mouth touch frequency sex. Associations...