A5059880519- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Colorectal and Anal Carcinomas
- Hepatocellular Carcinoma Treatment and Prognosis
- Genetic factors in colorectal cancer
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Screening and Detection
- Radiomics and Machine Learning in Medical Imaging
- Cancer, Lipids, and Metabolism
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Genomics and Diagnostics
- Cancer-related gene regulation
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Gastrointestinal Tumor Research and Treatment
- Epigenetics and DNA Methylation
- Inflammatory Biomarkers in Disease Prognosis
- Pancreatic and Hepatic Oncology Research
- Neuroendocrine Tumor Research Advances
- Cancer-related molecular mechanisms research
- Advanced biosensing and bioanalysis techniques
Sun Yat-sen University
2016-2025
Sun Yat-sen University Cancer Center
2016-2025
State Key Laboratory of Oncology in South China
2016-2025
Key Laboratory of Guangdong Province
2014-2024
Second Affiliated Hospital of Nanjing Medical University
2024
Colorectal Surgical Associates
2017
Sunnybrook Health Science Centre
2016
Health Sciences Centre
2016
Metabolic enzymes have an indispensable role in metabolic reprogramming, and their aberrant expression or activity has been associated with chemosensitivity. Hence, targeting remains attractive approach for treating tumors. However, the influence regulation of cysteine desulfurase (NFS1), a rate-limiting enzyme iron-sulfur (Fe-S) cluster biogenesis, colorectal cancer (CRC) remain elusive. Here, using vivo gene-based clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9...
Objective Methionine metabolism is involved in a myriad of cellular functions, including methylation reactions and redox maintenance. Nevertheless, it remains unclear whether methionine metabolism, RNA antitumour immunity are molecularly intertwined. Design The effect methionine-restricted diet (MRD) feeding was assessed murine models. mechanisms YTH domain-containing family protein 1 (YTHDF1) tumour immune escape were determined vitro vivo. synergistic effects MRD or YTHDF1 depletion with...
Bevacizumab plays an important role in the first and second line treatment for metastatic colorectal cancer (CRC). And induction of hypoxia tumors response to it determining efficacy antiangiogenic therapy while connection between them remains unclear. Here, we found that lactate accumulated tumor environment CRC acted as substrates histone lactylation, this process was further induced by cellular enhanced glycolysis hypoxia. We determined patients resistant bevacizumab presented with...
Abstract Fat mass and obesity-associated protein (FTO), an N6-methyladenosine (m 6 A) demethylase, participates in tumor progression metastasis many malignancies, but its role colorectal cancer (CRC) is still unclear. Here, we found that FTO levels, not RNA were downregulated CRC tissues. Reduced expression was correlated with a high recurrence rate poor prognosis resectable patients. Moreover, demonstrated hypoxia restrained expression, mainly due to increase ubiquitin-mediated degradation....
Abstract 5-Methylcytosine (m 5 C) is a posttranscriptional RNA modification participating in many critical bioprocesses, but its functions human cancer remain unclear. Here, by detecting the transcriptome-wide m C profiling esophageal squamous cell carcinoma (ESCC), we showed increased methylation ESCC tumors due to overexpressed methyltransferase NSUN2. Aberrant expression of NSUN2 was positively regulated E2F Transcription Factor 1 (E2F1). High levels predicted poor survival patients....
The current study aimed to establish a novel nomogram predict the overall survival of individual Chinese patients with gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs). Furthermore, this sought externally validate using Surveillance, Epidemiology, and End Results (SEER) database. records 1183 GEP-NENs treated at five high-capacity institutions in China between 2005 2015 were retrospectively analysed. In addition, 10 236 GEP-NEN cases from SEER database included as an external...
To compare neoadjuvant chemotherapy (nCT) with CAPOX alone versus chemoradiotherapy (nCRT) capecitabine in locally advanced rectal cancer (LARC) uninvolved mesorectal fascia (MRF).nCRT is associated higher surgical complications, worse long-term functional outcomes, and questionable survival benefits. Comparatively, nCT seems a promising alternative treatment lower-risk LARC patients MRF.Patients between June 2014 October 2020 within 12 cm from the anal verge MRF were randomly assigned to...
Continuous de novo fatty acid synthesis is required for the biosynthetic demands of tumor. FBXW7 a highly mutated gene in CRC, but its biological functions cancer are not fully characterized. Here, we report that FBXW7β, isoform located cytoplasm and frequently an E3 ligase synthase (FASN). Cancer-specific FBXW7β mutations could degrade FASN can lead to sustained lipogenesis CRC. COP9 signalosome subunit 6 (CSN6), oncogenic marker increases via interacting with stabilizing FASN. Mechanistic...
Abstract Background Liver metastasis is the leading cause of death in patients with colorectal cancer (CRC). Emerge evidence suggests that circular RNA (circRNA) a pivotal player progression. However, its role CRC liver remains largely unknown. Methods Circ-YAP expression was detected by qRT-PCR and situ hybridization. The function circ-YAP tested wound healing, transwell CCK-8 assays. immunoprecipitation, pull-down, luciferase reporter, chromatin immunoprecipitation assays were used to...
Objective Metastasis is the major cause of cancer death. However, what types heterogenous cells in primary tumour and how they metastasise to target organs remain largely undiscovered. Design We performed single-cell RNA sequencing spatial transcriptomic analysis colorectal (CRC) metastases liver (lCRC) or ovary (oCRC). also conducted immunofluorescence staining functional experiments examine mechanism. Results Integrative analyses epithelial reveal a stem-like cell cluster with high protein...
Abstract Eukaryotic initiation translation factor 3 subunit h (EIF3H) plays critical roles in regulating translational and predicts poor cancer prognosis, but the mechanism underlying EIF3H tumorigenesis remains to be further elucidated. Here, we report that is overexpressed colorectal (CRC) correlates with prognosis. Conditional Eif3h deletion suppresses AOM/DSS model. Mechanistically, functions as a deubiquitinase for HAX1 stabilizes via antagonizing βTrCP-mediated ubiquitination, which...
Chromodomain helicase DNA binding protein (CHD) family plays critical roles in regulating gene transcription. The is linked to cancer disease, but the member's role tumorigenesis remains largely unknown. Here, we report that CHD6 highly expressed colorectal (CRC). knockdown inhibited cell proliferation, migration, invasion, and tumorigenesis. Consistently, Villin-specific Chd6 knockout mice attenuates formation AOM/DSS model. We found aberrant EGF signals promoted stability of by diminishing...
This study aimed to validate the prognostic value of Immunoscore (IS) in stage II colorectal cancer (CRC), and explore roles IS circulating tumor DNA (ctDNA) adjuvant treatment for early-stage CRC. Resected samples from CRC patients were collected Sun Yat-sen University Cancer Center. The densities CD3+ CD8+ lymphocytes quantified converted classified into Low, Intermediate (Int), High groups according predefined cutoffs. A total 113 included study. Patients with IS-High, Int, Low 43 (38%),...
// Junzhong Lin 1,* , Miaozhen Qiu 2,3,* Ruihua Xu 2,* and Adrian Sandra Dobs 4 1 Department of Colorectal Surgery, Sun Yat-Sen University Cancer Center, State Key Laboratory Oncology in South China, Collaborative Innovation Center for Medicine, Guangzhou, China 2 Medical Oncology, 3 The Sidney Kimmel Comprehensive Johns Hopkins School Baltimore, MD, USA Division Endocrinology, Diabetes Metabolism, to Reduce Disparities, * These authors have contributed equally this work Correspondence to:...
In addition to tumor factors, poor nutritional status before and during anti-tumor treatment might compromise prognosis in several types of cancer. This study was done determine the impact weight loss preoperative chemoradiotherapy (CRT) on survival outcome patients with locally advanced rectal cancer (LARC).The retrospective examined consecutive LARC who underwent CRT followed by radical resection a single institute, between 2003 2013. Correlation proportional body mass index (BMI) change...
Systemic inflammation was recognized as an essential factor contributing to the development of malignancies. This study aimed investigate prognostic value pre-operative lymphocyte-to-monocyte ratio (LMR), neutrophil-to-lymphocyte (NLR), and platelet-to-lymphocyte (PLR) in patients with colorectal liver-only metastases (CLOM) undergoing hepatectomy. We retrospectively enrolled 150 consecutive CLOM between 2000 2012. The optimal cutoff values continuous LMR, NLR, PLR were determined using...
Oligometastatic disease can potentially be cured when an optimal approach is performed. Early recurrence after liver resection intractable problem, and the clinical implications remain unknown in colorectal oligometastases (CLOM) patients. This study aimed to investigate characteristics, risk factors, prognosis related early these patients.A total of 307 consecutive patients with CLOM undergoing curative were retrospectively reviewed between September 1999 June 2016. was defined as any or...
Abstract Background Although colorectal oligometastases to the liver can potentially be cured with aggressive local ablation, efficacy of adjuvant chemotherapy (ACT) for such metastasis remains unclear. The present study explored effects ACT on patients (CLO) after curative resections and aimed identify who could benefit from ACT. Methods We retrospectively analyzed 264 eligible CLO underwent resection between September 1999 June 2015. Recurrence‐free survival (RFS) overall (OS) were using...
Objective: To investigate the prognostic impact of perineural invasion in patients with stageⅢ colon cancer and to clarify its guidance value for duration postoperative adjuvant chemotherapy. Methods: This study employed a retrospective cohort method. It analyzed 426 who underwent radical surgery at Sun Yat-sen University Cancer Center Longyan First Affiliated Hospital Fujian Medical University, between April 2008 June 2020. Inclusion criteria: received least 3 months CapeOX therapy...
Purpose: This study aimed at investigating the long-term outcomes of oxaliplatin and capecitabine (XELOX) administered concurrently with preoperative radiation extended to resting period in patients high-risk locally advanced rectal cancer (LARC). Methods: From January 2010 December 2013, 45 were recruited. Study treatment consisted two cycles XELOX regimen concomitant then followed by an additional cycle between completion neoadjuvant radiotherapy surgery. Disease-free survival (DFS) time...
Purpose:The prognostic nutritional index (PNI) has been correlated with long-term outcomes in various cancer patients.However, the relationship between PNI and patients colorectal liver metastasis (CRLM) who have undergone surgery not fully investigated.In this study, we aimed to identify impact of preoperative on oncologic CRLM curative hepatic resection.Methods: A total 243 underwent resection for metastases Sun Yat-sen University Cancer Center September 1999 July 2015 were enrolled, their...