A5101847187- Colorectal Cancer Surgical Treatments
- Genetic factors in colorectal cancer
- Colorectal and Anal Carcinomas
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Cancer Genomics and Diagnostics
- Colorectal Cancer Screening and Detection
- Photorefractive and Nonlinear Optics
- Cancer Immunotherapy and Biomarkers
- Photonic and Optical Devices
- Head and Neck Cancer Studies
- PARP inhibition in cancer therapy
- Luminescence Properties of Advanced Materials
- Melanoma and MAPK Pathways
- Diamond and Carbon-based Materials Research
- Lymphoma Diagnosis and Treatment
- Hippo pathway signaling and YAP/TAZ
- Cancer Cells and Metastasis
- Hepatocellular Carcinoma Treatment and Prognosis
- Head and Neck Surgical Oncology
- Advanced Fiber Laser Technologies
- Glass properties and applications
- Cancer, Hypoxia, and Metabolism
- Anorectal Disease Treatments and Outcomes
- Molecular Biology Techniques and Applications
Southern Medical University
2008-2025
Sun Yat-sen University Cancer Center
2016-2025
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2022-2025
Wenzhou Medical University
2022-2025
Peking University People's Hospital
2025
Peking University
2011-2025
Affiliated Hospital of Nantong University
2014-2025
Nantong University
2012-2025
Sun Yat-sen University
2016-2025
Chinese Academy of Sciences
2006-2025
Rare earth ions (Tm3+, Er3+, and Yb3+)-doped cubic Gd2O3 nanocrystals were prepared by a simple sol−gel method. Raman FT-IR spectra measured to evaluate the vibrational feature of samples. Under 980 nm laser excitation, blue (488 nm), green (564 red (661 nm) upconversion has been recorded in Gd2O3:Tm+Yb Gd2O3:Er (Gd2O3:Er+Yb), respectively. A great enhancement emission diminishment Er3+ Gd2O3:Er+Yb have observed. Laser power doping concentration dependence upconverted emissions studied...
Abstract The signaling mechanisms between prostate cancer cells and infiltrating immune may illuminate novel therapeutic approaches. Here, utilizing a adenocarcinoma model driven by loss of Pten Smad4, we identify polymorphonuclear myeloid-derived suppressor (MDSC) as the major cell type, depletion MDSCs blocks progression. Employing dual reporter model, epithelial stromal transcriptomic profiling identified CXCL5 cancer-secreted chemokine to attract CXCR2-expressing MDSCs, and,...
KIT aberrations were described in acral and mucosal melanomas largely Caucasian populations. Asian populations are more prone to develop than cutaneous melanomas, may harbor a high frequency of aberrations.Melanoma subtypes (n = 502) analyzed histologically determine melanoma subtype. Tissue samples for mutations exons 9, 11, 13, 17, 18 gene genomic DNA by PCR amplification Sanger sequencing. The copy numbers the quantitative PCR, protein expression levels (CD117) determined...
Precise methods for postoperative risk stratification to guide the administration of adjuvant chemotherapy (ACT) in localized colorectal cancer (CRC) are still lacking. Here, we conducted a prospective, observational, and multicenter study investigate utility circulating tumor DNA (ctDNA) predicting recurrence risk.
No combined immunotherapy and antiangiogenic therapy have been investigated in exclusively programmed death-ligand 1 (PD-L1)-positive advanced cervical cancer (CA). We the efficacy safety of sintilimab plus anlotinib as second-line or later for PD-L1-positive recurrent metastatic (R/M) CA.Patients with (Combined Positive Score ≥ 1) R/M CA who progressed after at least one prior systemic chemotherapeutic regimen could not tolerate chemotherapy were eligible phase II trial. The patients...
Background Advanced triple-negative breast cancer (TNBC) is prone to brain metastasis (BrM). The precise molecular mechanism responsible for this phenomenon has not yet been completely established, so it vital comprehend the behind it. Methods protein chip analysis was conducted identify any abnormal UBE2T expression in TNBC, especially BrM. Here, we used public databases and bioinformatics as well clinical samples from different cohorts investigate interrelationship between...
Abstract Background The management of chronic diabetic wounds remains a formidable challenge in clinical practice. Persistent hyperglycemia triggers vasculopathy, neuropathy, and immune dysfunction, critically impeding wound repair. We developed multifunctional hydrogel (DPFI) engineered for sequential therapeutic actions, including antibacterial, anti-inflammatory, antioxidant, pro-vascularization/epithelialization, glycemic-regulating properties, to address these complications. Methods...
Abstract The medical records of 493 patients with restless legs syndrome (RLS) from three major centers were studied to determine the number and outcome who had been treated opioids as a monotherapy. At one time or another 113 (51 men, 62 women; age range, 37–88 years) on opioid therapy either alone (36 patients) added secondarily other medications used treat RLS (77 patients). Twenty‐three 36 monotherapy failed dopaminergic therapeutic agents prior initiation Twenty continue for an average...
The prognostic values of staging parameters require continual re-assessment amid changes in diagnostic and therapeutic methods. This study aimed to identify the factors failure patterns non-metastatic nasopharyngeal carcinoma (NPC) intensity-modulated radiotherapy (IMRT) era. We reviewed data from 749 patients with newly diagnosed, biopsy-proven, NPC our cancer center (South China, an endemic area) between January 2003 December 2007. All underwent magnetic resonance imaging (MRI) before...
Abstract Following mutations in BRAF and NRAS, the RAC1 c.85C>T single-nucleotide variant (SNV) encoding P29S amino acid change represents next most frequently observed protein-coding hotspot mutation melanoma. However, biologic clinical significance of somatic approximately 4% to 9% patients remains unclear. Here, we demonstrate that melanoma cell lines possessing are resistant RAF inhibitors (vemurafenib dabrafenib). Enforced expression sensitive BRAF-mutant confers resistance...
Abstract Profiling heterologous cell types within tumors is essential to decipher tumor microenvironment that shapes progress and determines the outcome of therapeutic response. Here, we comprehensively characterized transcriptomes 34,037 single cells obtained from 12 treatment‐naïve patients with colorectal cancer. Our comprehensive evaluation revealed attenuated B‐cell antigen presentation, distinct regulatory T‐cell clusters different origin novel polyfunctional associated macrophages...
The genetic basis of colorectal cancer (CRC) and its clinical associations remain poorly understood due to limited samples or targeted genes in current studies. Here, we perform ultradeep whole-exome sequencing on 1015 patients with CRC as part the ChangKang Project. We identify 46 high-confident significantly mutated genes, 8 which mutate 14.9% patients: LYST, DAPK1, CR2, KIF16B, NPIPB15, SYTL2, ZNF91, KIAA0586. With an unsupervised clustering algorithm, propose a subtyping strategy that...
To compare neoadjuvant chemotherapy (nCT) with CAPOX alone versus chemoradiotherapy (nCRT) capecitabine in locally advanced rectal cancer (LARC) uninvolved mesorectal fascia (MRF).nCRT is associated higher surgical complications, worse long-term functional outcomes, and questionable survival benefits. Comparatively, nCT seems a promising alternative treatment lower-risk LARC patients MRF.Patients between June 2014 October 2020 within 12 cm from the anal verge MRF were randomly assigned to...