A5060545410- Renal and related cancers
- Epigenetics and DNA Methylation
- Renal cell carcinoma treatment
- Tuberous Sclerosis Complex Research
- Cancer-related Molecular Pathways
- Microtubule and mitosis dynamics
- Uterine Myomas and Treatments
- Genetic and Kidney Cyst Diseases
- Endometriosis Research and Treatment
- Effects and risks of endocrine disrupting chemicals
- Cancer-related gene regulation
- RNA modifications and cancer
- Autophagy in Disease and Therapy
- Cancer, Hypoxia, and Metabolism
- Chromatin Remodeling and Cancer
- Cancer Genomics and Diagnostics
- Genomics and Chromatin Dynamics
- Ferroptosis and cancer prognosis
- Occupational and environmental lung diseases
- Ubiquitin and proteasome pathways
- Education, Achievement, and Giftedness
- Pancreatic and Hepatic Oncology Research
- Disaster Response and Management
- Neuroblastoma Research and Treatments
- Carcinogens and Genotoxicity Assessment
Baylor College of Medicine
2016-2025
Walker (United States)
2025
The University of Texas MD Anderson Cancer Center
2005-2023
Genesis Foundation
2023
University of Chicago
2023
McGill University
2005-2021
Carleton College
2021
Baylor Genetics
2021
The Hunterian
2021
Adam Smith Institute
2021
Significance NO exposure triggered an ATM-mediated damage response in breast cancer cells involving activation of the LKB1 and TSC2 tumor suppressors, repression mTORC1, ULK phosphorylation, increased autophagic flux. The associated loss cell viability indicates that autophagy can function as a cytotoxic to nitrosative stress cells. Collectively, data identify nitrosative-stress signaling pathway regulates autophagy. A more comprehensive understanding pathways regulating holds promise for...
Although rapid, membrane-activated estrogen receptor (ER) signaling is no longer controversial, the biological function of this nongenomic not fully characterized. We found that rapid from membrane-associated ER regulates histone methyltransferase enhancer Zeste homolog 2 (EZH2). In response to both 17beta-estradiol (E2) and xenoestrogen diethylstilbestrol, via phosphatidylinositol 3-kinase/protein kinase B phosphorylates EZH2 at S21, reducing levels trimethylation lysine 27 on H3 in...
Lymphangioleiomyomatosis (LAM) is an often fatal disease primarily affecting young women in which tuberin (TSC2)-null cells metastasize to the lungs. The mechanisms underlying striking female predominance of LAM are unknown. We report here that 17-beta-estradiol (E(2)) causes a 3- 5-fold increase pulmonary metastases male and mice, respectively, circulating tumor mice bearing tuberin-null xenograft tumors. E(2)-induced metastasis associated with activation p42/44 MAPK completely inhibited by...
Abstract The Developmental Origins of Health and Disease (DOHaD) paradigm is one the most rapidly expanding areas biomedical research. Environmental stressors that can impact on DOHaD encompass a variety environmental occupational hazards as well deficiency oversupply nutrients energy. They disrupt early developmental processes lead to increased susceptibility disease/dysfunctions later in life. Presentations at fourth Conference Prenatal Programming Toxicity Boston, October 2014, provided...
Previous studies in rodent models have shown that early-life exposure to bisphenol A (BPA) reprograms the prostate and enhances its susceptibility hormonal carcinogenesis with aging. To determine whether human is similarly sensitive BPA, current study used epithelial stem-like cells cultured from prostates of young, disease-free donors. Similar estradiol-17β (E2), BPA increased stem-progenitor cell self-renewal expression stem-related genes a dose-dependent manner. Further, 10 nM E2...
The link between reactive oxygen species (ROS) and induction of autophagy has been well documented, but the molecular mechanisms regulating this phenomenon are only beginning to be elucidated. Autophagy is now being appreciated as an integral part cellular response many diverse types stresses including nutrient deprivation, hypoxia, oxidative stress, DNA damage, likely mechanism(s) for each type stress vary considerably. outcome inducing in also quite complex, depends on factors context,...
Mutations in SETD2, a histone H3 lysine trimethyltransferase, have been identified clear cell renal carcinoma (ccRCC); however it is unclear if loss of SETD2 function alters the genomic distribution 3 36 trimethylation (H3K36me3) ccRCC. Furthermore, published epigenomic profiles are not specific to H3K36me3 or metastatic tumors. To determine progressive and dysregulation occurs tumors, H3K36me3, copy number (CN) mRNA abundance was assessed two independent cohorts: ccRCC (n=71) Cancer Genome...