A5041087708- Renal cell carcinoma treatment
- Cancer, Hypoxia, and Metabolism
- MRI in cancer diagnosis
- Ubiquitin and proteasome pathways
- Autophagy in Disease and Therapy
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Photosynthetic Processes and Mechanisms
- Genetic and Kidney Cyst Diseases
- Cancer Genomics and Diagnostics
- Algal biology and biofuel production
- Immune cells in cancer
- Fibroblast Growth Factor Research
- Meat and Animal Product Quality
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Endoplasmic Reticulum Stress and Disease
- Food and Agricultural Sciences
- Nanocomposite Films for Food Packaging
- CRISPR and Genetic Engineering
- DNA Repair Mechanisms
- Immune Cell Function and Interaction
- Renal and related cancers
- Pluripotent Stem Cells Research
- Phagocytosis and Immune Regulation
The University of Texas MD Anderson Cancer Center
2014-2023
Spanish Oncology Genitourinary Group
2006-2015
University of California, San Diego
2014
Baylor College of Medicine
2007-2013
University of Houston
2013
Nanjing University of Posts and Telecommunications
2013
Yangpu Hospital of Tongji University
2012
Chungnam National University
2009-2012
Pulmonary and Critical Care Associates
2012
China Pharmaceutical University
2003-2011
Renal cell carcinoma (RCC) is an immunogenic and proangiogenic cancer, antiangiogenic therapy the current mainstay of treatment. Patients with RCC develop innate or adaptive resistance to therapy. There a need identify biomarkers that predict therapeutic guide combination We assessed interaction between tumor immune microenvironment determined their impact on clinical outcome. found therapy-treated primary tumors showed increased infiltration CD4(+) CD8(+) T lymphocytes, which was inversely...
Mechanistic insights into kidney cancer Many clear cell renal carcinomas (ccRCCs) have alterations to the gene encoding von Hippel-Lindau protein (VHL). VHL is a ubiquitin ligase that degrades target proteins when they are prolyl-hydroxylated. Zhang et al. performed genome-wide search for (see Perspective by Sanchez and Simon). They identified ZHX2, with structural motifs indicate DNA binding. ZHX2 has been implicated in tumor suppression. Loss of inhibited signaling through transcription...
Abstract A non-immunogenic tumor microenvironment (TME) is a significant barrier to immune checkpoint blockade (ICB) response. The impact of Polybromo-1 ( PBRM1 ) on TME and response ICB in renal cell carcinoma (RCC) remains be resolved. Here we show that / Pbrm1 deficiency reduces the binding brahma-related gene 1 (BRG1) IFNγ receptor 2 Ifngr2 promoter, decreasing STAT1 phosphorylation subsequent expression target genes. An analysis 3 independent patient cohorts murine pre-clinical models...
CRISPR-Cas9 gene-editing technology has facilitated the generation of knockout mice, providing an alternative to cumbersome and time-consuming traditional embryonic stem cell-based methods. An earlier study reported up 16% efficiency in generating conditional (cKO or floxed) alleles by microinjection 2 single guide RNAs (sgRNA) single-stranded oligonucleotides as donors (referred herein "two-donor floxing" method).We re-evaluate two-donor method from a consortium 20 laboratories across...
Autophagy has recently been shown to be an important component of the innate immune response. The signaling pathways leading activation autophagy in immunity are not well studied. Our recent study shows that Toll-like receptor 4 (TLR 4) serves as environmental sensor for autophagy. We define a new molecular pathway which lipopolysaccharide (LPS) induces human and murine macrophages by regulated through Toll-interleukin 1 domain-containing adaptor-inducing interferon-beta (TRIF)-dependent,...
Failure to maintain protein homeostasis (proteostasis) leads accumulation of unfolded proteins and contributes the pathogenesis many human diseases. Accumulation in endoplasmic reticulum (ER) elicits response (UPR) that serves attenuate translation, increase refolding or degradation. In contrast UPR ER, regulatory molecules operative cytosolic responses their potential relation ER stress are not well elucidated. Aggresome-like induced structures (ALIS) have been described as transient...
Abstract Purpose: Clear cell renal carcinoma (ccRCC) is frequently associated with inactivation of the von Hippel–Lindau tumor suppressor, resulting in activation HIF-1α and HIF-2α. The current paradigm, established using mechanistic cell-based studies, supports a promoting role for HIF-2α, suppressor HIF-1α. However, few studies have comprehensively examined clinical relevance this paradigm. Furthermore, hypoxia-associated factor (HAF), which regulates HIFs, has not been evaluated ccRCC....
We report a magneto-fluorescent theranostic nanocomplex targeted to neutrophil gelatinase-associated lipocalin (NGAL) for imaging and therapy of pancreatic cancer.Gold nanoshells resonant at 810 nm were encapsulated in silica epilayers doped with iron oxide the near-infrared (NIR) dye indocyanine green, resulting gold (TGNS), which subsequently conjugated antibodies targeting NGAL AsPC-1-derived xenografts nude mice.Anti-NGAL-conjugated TGNS specifically cancer cells vitro vivo providing...
The Korean native chickens (Woorimotdak™, KNC) and commercial broilers (Ross, CB) show obvious differences in meat flavor after cooking. To understand the contribution of protein peptide for flavor, 2-dimensional (2-D) gel electrophoresis matrix-assisted laser desorption-ionization time-of-flight (MALDI-TOF) mass spectrometry was performed. A total 16 spots were differentially expressed breast thigh between two breeds. seven represented by different levels KNC CB meat. Among them three...
We investigated a high power diode-laser pumped passively Q-switched c-cut Nd:GdVO 4 solid-state laser, lasing at 1.34 μm, with Co 2+ :LaMgAl 11 O 19 saturable absorber. With the optimum output coupler transmission T =5.5% and pump of 11.5 W, static 3.01 W was obtained. The Q-switching operation Co:LMA (initial 0 =90%) as absorber, shows that shortest pulse width, highest power, repetition peak were 32 ns, 266 mW, 277 kHz, 187 respectively.
// Guibin Xu 1, 2, 3, * , Yaodong Jiang 4, Yuansong Xiao 5, Xian-De Liu 6 Fei Yue 3 Wenjiao Li Xun 2 Yongzhong He Xianhan Hai Huang Qi Chen Eric Jonasch Leyuan 7 1 Department of Urology, The Fifth Affiliated Hospital Guangzhou Medical University, Guangzhou, Guangdong Province, 510700, China Center for Innovation and Translation Minimally Invasive Techniques, Institute Biosciences Technology, Texas A&M Health Science Center, Houston, Texas, 77030, USA 4 Nanfang Hospital, Southern 510515, 5...
Light could induce phosphorylation of light harvesting chlorophyll a / b binding proteins (LHCII) in Dunaliella salina and spinach thylakoid membranes. We found that neither was affected by glycerol, whereas treatment with NaCl significantly enhanced light‐induced LHCII D. membranes inhibited spinach. Furthermore, even the absence light, several other salts induced membranes, but not In addition, hypertonic shock intact under dark conditions cells adapted to different concentrations...
Abstract Purpose: Immune checkpoint blockade (ICB) demonstrates durable clinical benefits in a minority of patients with renal cell carcinoma (RCC). We aimed to identify the molecular features that determine response and develop approaches enhance it. Experimental Design: investigated effects SET domain-containing protein 2 (SETD2) loss on DNA damage pathway, cytosolic DNA-sensing tumor immune microenvironment, ataxia telangiectasia rad3-related (ATR) inhibition RCC. Results: ATR activated...
The aim of this study was to investigate effects type 2 diabetes on the pharmacokinetics verapamil after intravenous administration.