A5076171124- Epigenetics and DNA Methylation
- Birth, Development, and Health
- Health, Environment, Cognitive Aging
- Estrogen and related hormone effects
- Regulation of Appetite and Obesity
- Neonatal Respiratory Health Research
- Neuroscience of respiration and sleep
- Effects and risks of endocrine disrupting chemicals
- Air Quality and Health Impacts
- Heavy Metal Exposure and Toxicity
- RNA modifications and cancer
- Fibroblast Growth Factor Research
- Arsenic contamination and mitigation
- Bioactive Compounds and Antitumor Agents
- Genetic Syndromes and Imprinting
- Hormonal and reproductive studies
- Biochemical Analysis and Sensing Techniques
- Extracellular vesicles in disease
- Kruppel-like factors research
- Genetics and Neurodevelopmental Disorders
- Asthma and respiratory diseases
- Obstructive Sleep Apnea Research
- Body Composition Measurement Techniques
- Reproductive System and Pregnancy
- Cancer-related gene regulation
University of Pittsburgh
2020-2025
Pittsburg State University
2025
Children's Hospital of Fudan University
2023-2025
Johns Hopkins University
2012-2021
Johns Hopkins Medicine
2021
Jilin University
2018-2021
First Hospital of Jilin University
2018-2021
Southern Medical University
2021
Bloomberg (United States)
2017-2020
University of Iowa
2017
Abstract Early developmental perturbations have been linked to adult-onset prostate pathology, including excessive exposure estrogenic compounds; however, the molecular basis for this imprinting event is not known. An important and controversial health concern whether low-dose exposures hormonally active environmental estrogens, such as bisphenol A, can promote human diseases, cancer. Here, we show that transient of rats low, environmentally relevant doses A or estradiol increases gland...
In a longitudinal cohort of approximately 700 children in New York City, the prevalence asthma (>25%) is among highest US. This high risk may part be caused by transplacental exposure to traffic-related polycyclic aromatic hydrocarbons (PAHs) but biomarkers informative PAH-asthma relationships lacking. We here hypothesized that epigenetic marks associated with PAH and/or childhood could identified fetal tissues. Mothers completed personal prenatal air monitoring for determination....
Significance Biological sex is typically not considered in the evaluation of vaccine responses and protection against infection. We show that female mice mount greater humoral cell-mediated immune to influenza infection vaccination than males. Females can rely solely on antibody for following vaccination, which associated with expression toll-like receptor 7 ( Tlr7 ) caused by epigenetic mechanisms B cells from females. Deletion reduces differences vaccine-induced protection. The increased...
Abstract Extracellular matrix stiffening is a quintessential feature of cartilage aging, leading cause knee osteoarthritis. Yet, the downstream molecular and cellular consequences age-related biophysical alterations are poorly understood. Here, we show that epigenetic regulation α-Klotho represents novel mechanosensitive mechanism by which aged extracellular influences chondrocyte physiology. Using mass spectrometry proteomics followed series genetic pharmacological manipulations, discovered...
Neonatal exposure of CD-1 mice to diethylstilbestrol (DES) or genistein (GEN) induces uterine adenocarcinoma in aging animals. Uterine carcinogenesis this model is ovarian dependent because its evolution blocked by prepubertal ovariectomy. This study seeks discover novel genes whose expression altered such early endocrine disruption via an epigenetic mechanism. were treated with 1 1000 μg/kg DES, 50 mg/kg GEN, oil (control) on d 1–5. One group was killed before puberty 19. Others...
Evidence supporting an early origin of prostate cancer is growing. We demonstrated previously that brief exposure neonatal rats to estradiol or bisphenol A elevated their risk developing precancerous lesions in the upon androgen-supported treatment with as adults. Epigenetic reprogramming may be a mechanism underlying this inductive event life, because we observed overexpression phosphodiesterase 4D variant 4 (Pde4d4) through induction hypomethylation its promoter. This epigenetic mark was...
Maternal factors are implicated in the onset of childhood asthma. Differentiation naïve CD4+ T lymphocytes into pro-allergic T-helper 2 cells induces interleukin (IL)4 expression and inhibits interferon (IFN)γ accompanied by concordant methylation changes promoters these genes. However, it has yet to be established whether maternal exposure polycyclic aromatic hydrocarbons (PAHs) can alter gene epigenetically during fetal development.In this study we sought elucidate relationship between PAH...
Abstract While young muscle is capable of restoring the original architecture damaged myofibers, aged displays a markedly reduced regeneration. We show that expression “anti-aging” protein, α-Klotho, up-regulated within injured as result transient Klotho promoter demethylation. However, epigenetic control lost with aging. Genetic inhibition α-Klotho in vivo disrupted progenitor cell (MPC) lineage progression and impaired myofiber regeneration, revealing critical role for regenerative...
The association between human blood DNA global methylation and hydroxymethylation has not been evaluated in population-based studies. No studies have environmental determinants of hydroxymethylation, including exposure to metals.We the 48 Strong Heart Study participants for which selected metals had measured urine at baseline was available from 1989-1991 (visit 1) 1998-1999 3).We percentage 5-methylcytosine (5-mC) 5-hydroxymethylcytosine (5-hmC) samples using capture detection antibodies...
The epigenetic effects of individual environmental toxicants in tobacco remain largely unexplored. Cadmium (Cd) has been associated with smoking-related health effects, and its concentration smoke is higher comparison other metals.
Two flavonoids, genistein and apigenin, have been implicated as chemopreventive agents against prostate breast cancers. However, the mechanisms behind their respective cancer-protective effects may vary significantly. The goal of this study was to determine whether antiproliferative action these flavonoids on (DU-145) (MDA-MB-231) cancer cells expressing only estrogen receptor (ER) β is mediated by ER subtype. It found that both although not 17β-estradiol, exhibited anti proliferative...
While lipid emulsion may reverse the systemic toxicity of bupivacaine, pharmacokinetics and tissue distribution bupivacaine after infusion are not clear. In this study, we assessed influence administration on bupivacaine.Rats in group were administered IV at rate 2 mg·kg(-1)·min(-1) for 4 minutes, then treated with an 30% 3 mL·kg(-1)·min(-1) 5 minutes; saline was substituted control (n = 6 pharmacokinetics). We randomly assigned 100 rats into 50 distribution). The model treatment same as...
Developmental exposure to endocrine-disrupting chemicals (EDCs), 17β-estradiol-3-benzoate (EB) and bisphenol A (BPA), increases susceptibility prostate cancer (PCa) in rodent models. Here, we used the methylated-CpG island recovery assay (MIRA)-assisted genomic tiling CpG arrays identify treatment-associated methylome changes postnatal day (PND)90 dorsal tissues of Sprague-Dawley rats neonatally (PND1, 3, 5) treated with 25 µg/pup or 2,500 µg EB/kg body weight (BW) 0.1 BPA/pup 10 BPA/kg BW....
Obesity leads to resistant hypertension and mechanisms are poorly understood, but high plasma levels of leptin have been implicated. Leptin increases blood pressure acting both centrally in the dorsomedial hypothalamus peripherally. Sites peripheral hypertensive effect not identified. We previously reported that enhanced activity carotid sinus nerve, which transmits chemosensory input from bodies (CBs) medullary centers, this was abolished by nonselective blockers Trp (transient receptor...
American Indian communities experience a high burden of coronary heart disease (CHD). Strategies are needed to identify individuals at risk and implement preventive interventions.To investigate the association blood DNA methylation (DNAm) with incident CHD using large number sites (cytosine-phosphate-guanine [CpG]) in single model.This prospective study, including discovery cohort (the Strong Heart Study [SHS]) 4 additional cohorts Women's Health Initiative [WHI], Framingham [FHS],...