A5038725090- Arsenic contamination and mitigation
- Cardiovascular Function and Risk Factors
- Heavy Metal Exposure and Toxicity
- Genetic Associations and Epidemiology
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Health and Risk Factors
- Birth, Development, and Health
- Blood Pressure and Hypertension Studies
- Cardiovascular Disease and Adiposity
- Cardiac Imaging and Diagnostics
- Nutritional Studies and Diet
- Liver Disease Diagnosis and Treatment
- Cardiovascular Health and Disease Prevention
- Adipokines, Inflammation, and Metabolic Diseases
- Air Quality and Health Impacts
- Environmental Justice and Health Disparities
- Diet, Metabolism, and Disease
- Epigenetics and DNA Methylation
- Nutrition, Genetics, and Disease
- Telomeres, Telomerase, and Senescence
- Pregnancy and preeclampsia studies
- Fluoride Effects and Removal
- BRCA gene mutations in cancer
- Heavy metals in environment
- Genetic Syndromes and Imprinting
Missouri Breaks Industries Research (United States)
2016-2025
University of North Dakota
2006-2025
Turtle Mountain Community College
2009-2022
Lamont-Doherty Earth Observatory
2022
Columbia University
2022
Eagle Mount
2019
Tate & Lyle (United Kingdom)
2012-2019
Seattle Children's Hospital
2019
University of Oklahoma Health Sciences Center
2002-2017
Cornell University
2004-2017
High triglyceride (TG) levels and low HDL cholesterol (HDL-C) are risk factors for cardiovascular disease. It is unclear whether this relationship depends on glycemic dysregulation, sex, or LDL (LDL-C) level.We studied 3,216 participants (40% men, 41% with diabetes) who were free of disease at baseline in a community-based, prospective cohort American Indians (median follow-up 17.7 years). Cox models estimated hazard ratios (HRs) 95% CIs incident ischemic stroke coronary heart (CHD) relation...
Background: Long-term exposure to high levels of arsenic is associated with increased risk for cardiovascular disease, whereas from long-term low moderate (<100 µg/L in drinking water) unclear. Objective: To evaluate the association between and incident disease. Design: Prospective cohort study. Setting: The Strong Heart Study baseline visit 1989 1991, follow-up through 2008. Patients: 3575 American Indian men women aged 45 74 years living Arizona, Oklahoma, North South Dakota. Measurements:...
There are few data about the impact of recently-defined category prehypertension (systolic blood pressure 120 to 139 mm Hg or diastolic 80 89 Hg) on cardiovascular disease incidence. It is also unknown whether this association differs between individuals with without diabetes. A total 2629 Strong Heart Study participants free from hypertension and at baseline examination were followed for 12 years observe incident disease. Approximately 42% had We assessed prevalence hazard ratios associated...
This study estimated hypertension incidence and explored risk factors their association with cardiovascular disease. Data collected from 4549 American Indian participants in the 3 exams of Strong Heart Study were used. Hypertension was defined as systolic blood pressure ≥140 mm Hg, diastolic ≥90 or current use antihypertensive medication. Generalized linear models used to identify for correlates pressures. Cox proportional time-dependent covariates mixed explore There no sex difference...
Background— The epidemic of overweight is increasing the prevalence both prehypertension and early-onset hypertension, but few population-based data exist on their impact cardiac structure function in adolescents young adults. Methods Results— We analyzed clinical characteristics, hemodynamic parameters, left ventricular 1940 participants, 14 to 39 years age, Strong Heart Study. Hypertension occurred 294 participants (15%), who were more often men (70% versus 30%), older (age, 31±7 25±8...
Inorganic arsenic, a carcinogen at high exposure levels, is major global health problem. Prospective studies on carcinogenic effects low-moderate arsenic levels are lacking.
OBJECTIVE—Diabetes has been defined as a coronary heart disease (CHD) risk equivalent, and more aggressive treatment goals have proposed for diabetic patients. RESEARCH DESIGN AND METHODS—We studied the influence of single multiple factors on 10-year cumulative incidence fatal nonfatal CHD cardiovascular (CVD) in nondiabetic men women, with without baseline or CVD, population (n = 4,549) high prevalence diabetes. RESULTS—In both sexes, diabetes increased (hazard ratio 1.99 2.93...
Background and Purpose— Mitral annular calcification (MAC) aortic valve (AV) sclerosis have each been linked to cardiovascular disease. Whether MAC AV are risk factors for stroke independent of other echocardiographic or laboratory predictors has not established. We evaluated the relationship between MAC, sclerosis, first events in a population-based cohort. Methods— Our study cohort consisted 2723 American Indians participating Strong Heart Study who were free prevalent Participants...
Cadmium (Cd) is a toxic metal classified as human carcinogen by the International Agency for Research on Cancer.We evaluated association of long-term Cd exposure, measured in urine, with cancer mortality American Indians from Arizona, Oklahoma, and North South Dakota who participated Strong Heart Study during 1989-1991.The was prospective cohort study 3,792 men women 45-74 years age were followed up to 20 years. Baseline urinary (U-Cd) using inductively coupled plasma mass spectrometry. We...
Background— There are few published data on the incidence of fatal and nonfatal stroke in American Indians. The aims this observational study were to determine elucidate risk factors among Methods Results— This report is based 4549 participants aged 45 74 years at enrollment Strong Heart Study, largest longitudinal, population-based cardiovascular disease its a diverse group At baseline examination 1989 1992, 42 (age- sex-adjusted prevalence proportion 1132/100 000, adjusted age sex...
Telomeres play a central role in cellular aging, and shorter telomere length has been associated with age-related disorders including diabetes. However, causal link between shortening diabetes risk not established. In well-characterized longitudinal cohort of American Indians participating the Strong Heart Family Study, we examined whether leukocyte (LTL) at baseline predicts incident independent known factors. Among 2,328 participants free baseline, 292 subjects developed during an average...
OBJECTIVE Little is known about arsenic metabolism in diabetes development. We investigated the prospective associations of low-moderate exposure and with incidence Strong Heart Study. RESEARCH DESIGN AND METHODS A total 1,694 diabetes-free participants aged 45–75 years were recruited 1989–1991 followed through 1998–1999. used proportions urine inorganic (iAs), monomethylarsonate (MMA), dimethylarsinate (DMA) over their sum (expressed as iAs%, MMA%, DMA%) biomarkers metabolism. Diabetes was...
High arsenic exposure has been related to diabetes, but at low-moderate levels the evidence is mixed. Arsenic metabolism, which partly genetically controlled and may rely on certain B vitamins, plays a role in toxicity.We evaluated prospective association of metabolism with type 2 diabetes insulin resistance.We included 1,838 American Indian men women free (median age, 36 y). was assessed as sum inorganic (iAs), monomethylarsonate (MMA), dimethylarsinate (DMA) urine concentrations (ΣAs). by...
Background: Epigenetic dysregulation has been proposed as a key mechanism for arsenic-related cardiovascular disease (CVD). We evaluated differentially methylated positions (DMPs) potential mediators on the association between arsenic and CVD. Methods: Blood DNA methylation was measured in 2321 participants (mean age 56.2, 58.6% women) of Strong Heart Study, prospective cohort American Indians. Urinary species were using high-performance liquid chromatography coupled to inductively plasma...
Importance Numerous efforts have been made to include diverse populations in genetic studies, but American Indian are still severely underrepresented. Polygenic scores derived from data proposed clinical care, how polygenic perform individuals and whether they can predict disease risk this population remains unknown. Objective To study the performance of for cardiometabolic factors lipid traits C-reactive protein adults determine such helpful prediction diseases. Design, Setting,...