A5087559006- Osteoarthritis Treatment and Mechanisms
- Knee injuries and reconstruction techniques
- Lower Extremity Biomechanics and Pathologies
- Total Knee Arthroplasty Outcomes
- Tendon Structure and Treatment
- Musculoskeletal pain and rehabilitation
- Balance, Gait, and Falls Prevention
- Muscle activation and electromyography studies
- Muscle Physiology and Disorders
- Foot and Ankle Surgery
- Cerebral Palsy and Movement Disorders
- Diabetic Foot Ulcer Assessment and Management
- Spaceflight effects on biology
- Silk-based biomaterials and applications
- Sports injuries and prevention
- Orthopedic Surgery and Rehabilitation
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Mesenchymal stem cell research
- Extracellular vesicles in disease
- Cancer, Hypoxia, and Metabolism
- Inflammatory mediators and NSAID effects
- Genetics, Aging, and Longevity in Model Organisms
- Prosthetics and Rehabilitation Robotics
- Periodontal Regeneration and Treatments
- Color Science and Applications
Harvard University
2023-2025
Spaulding Rehabilitation Hospital
2023-2025
Nagoya University
2022-2024
University of Pittsburgh
2019-2023
Kyoto University
2014-2023
Keio University
2017-2023
Nagoya University Hospital
2022-2023
McGowan Institute for Regenerative Medicine
2019-2022
Japan Society for the Promotion of Science
2015-2022
Saitama Prefectural University
2022
Abstract Extracellular matrix stiffening is a quintessential feature of cartilage aging, leading cause knee osteoarthritis. Yet, the downstream molecular and cellular consequences age-related biophysical alterations are poorly understood. Here, we show that epigenetic regulation α-Klotho represents novel mechanosensitive mechanism by which aged extracellular influences chondrocyte physiology. Using mass spectrometry proteomics followed series genetic pharmacological manipulations, discovered...
This study aimed to investigate subchondral bone changes using micro-computed tomography (micro-CT) and regional differences in articular cartilage degeneration, focusing on of covered by menisci, the early phase a destabilization medial meniscus (DMM) model.The DMM model was created as an experimental rat osteoarthritis (OA) (12 weeks old; n = 24). At 1, 2, 4 after surgery, rats were sacrificed, knee joints scanned Micro-CT system. Histological sections tibial plateau, which divided into...
Depressive symptoms are a major comorbidity in older adults with knee osteoarthritis (OA). However, the type of activity-induced pain associated depression has not been examined. Furthermore, there is conflicting evidence regarding association between and performance-based physical function. This study aimed to examine (i) depressive intensity, particularly task-specific during daily living, (ii) function, while considering other potential risk factors, including bilateral ambulatory...
To compare the efficacy and adherence rates of two parallel home exercise therapy programs—multiple (training stretching knee hip muscles) control quadriceps muscles)—on pain, physical function, extension strength in community-dwelling elderly individuals with pre-radiographic osteoarthritis (OA). One hundred patients medial pain were randomly allocated to one 4-week programs. Individuals a Kellgren/Lawrence (K/L) grade 0 or 1 OA (pre-radiographic OA) compartment enrolled. Primary outcomes...
To examine the association of radiographic frontal plane knee alignment with three-dimensional foot posture in patients medial osteoarthritis (OA).Participants orthopedic clinics Kellgren/Lawrence (K/L) grade ≥1 (88 and 88 knees; age, 61-91 years; 65.9% female) were enrolled. An anteroposterior view was used to assess anatomical axis angle (AAA) after subtracting a sex-specific correction factor. The also evaluated.Multiple regression analyses showed that increased corrected AAA (i.e.,...
Muscle atrophy caused by immobilization in the shortened position is characterized a decrease size or cross-sectional area (CSA) of myofibers and decreased muscle length. Few studies have addressed relationship between limitation range motion (ROM) changes CSA specifically biarticular muscles after because immobilization. We aimed to determine contribution 2 distinct groups, post thigh (PT) those leg (PL), ROM as well myofiber CSAs joint surgery. Male Wistar rats (n = 40) were randomly...
Objective To investigate the association between knee pain during gait and 4 clinical phenotypes based on static varus alignment thrust in patients with medial osteoarthritis (OA). Methods Patients an orthopedic clinic (n = 266) diagnosed as having OA (Kellgren/Lawrence [K/L] grade ≥1) were divided into phenotype groups according to presence or absence of (dynamic varus): no 173), dynamic 17), 50), + 26). The range motion, spatiotemporal parameters, visual analog scale scores for pain,...
Low back pain (LBP) during pregnancy might be strongly related to posture and movements of the body, its management is a clinically important issue. The purpose this study was investigate activities LBP pregnancy.Participants included 275 women before 12 weeks pregnancy. were evaluated at 12, 24, 30, 36 intensity assessed using Numerical Rating Scale (NRS). Movements investigated by free descriptive answers. Descriptive statistics used compile that pregnant thought induced each evaluation....
To investigate the effect of transcutaneous electrical nerve stimulation (TENS) on knee pain and comprehensive physical function in preradiographic osteoarthritis.A single, participant-blinded, randomized controlled trial (RCT) with pre-post design.University research laboratory.Patients belonging to Kellgren-Lawrence grade 0 or 1 (N=50; aged 50-69y) were randomly assigned TENS (n=25) sham-TENS groups (n=25).All participants wore device under patella symptomatic knee. After measurement,...
The repair of articular cartilage is challenging owing to the restriction in ability itself. Therefore, cell supplementation therapy possible method. However, few studies have verified efficacy and safety therapy. current study assessed effect exercise on early phase following utilizing mesenchymal stromal (MSC) intra-articular injection. An osteochondral defect was created femoral grooves bilaterally Wistar rats. Mesenchymal cells that were obtained from male rats cultured monolayer. After...
ABSTRACT This cross‐sectional study examined the relationship of flat feet with knee pain, disability, and physical performance in patients osteoarthritis (OA). Orthopedic clinic participants ( n = 95; age 61–91 years; 68.4% women) Kellgren‐Lawrence (K/L) grade ≥1 medial compartment underwent evaluation navicular height foot length for feet. Knee pain intensity, were evaluated using Japanese Osteoarthritis Measure, 10‐m walk, timed up go, five‐repetition chair stand tests. Of 95 enrolled...
A mechanistic understanding of cell-autonomous skeletal muscle changes after injury can lead to novel interventions improve functional recovery in an aged population. However, major knowledge gaps persist owing limitations traditional biological aging models. 2D cell culture represents artificial environment, while mammalian models are contaminated by influences from non-muscle cells and other organs. Here, a 3D system is created overcome the these platforms. It shown that old constructs...