A5013979692- Autophagy in Disease and Therapy
- Luminescence and Fluorescent Materials
- Advanced Database Systems and Queries
- MicroRNA in disease regulation
- Nanoplatforms for cancer theranostics
- Molecular Sensors and Ion Detection
- Chaos-based Image/Signal Encryption
- Data Mining Algorithms and Applications
- Advanced biosensing and bioanalysis techniques
- Arsenic contamination and mitigation
- Crystallization and Solubility Studies
- Advanced Nanomaterials in Catalysis
- X-ray Diffraction in Crystallography
- Protein Degradation and Inhibitors
- Big Data and Business Intelligence
- Advanced Data Storage Technologies
- Cryptographic Implementations and Security
- Cancer-related molecular mechanisms research
- Synthesis and biological activity
- Data Management and Algorithms
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Retinoids in leukemia and cellular processes
- IoT-based Smart Home Systems
- TGF-β signaling in diseases
Birla Institute of Technology and Science, Pilani
2016-2025
Texas A&M University
2022
Poultry Research Institute
2017-2018
University of Kalyani
2012-2018
Institut Teknologi dan Sains Mandala
2014-2017
IIT@MIT
2013
Massachusetts Institute of Technology
2012
Indian Institute of Chemical Biology
2006-2010
Indian Institute of Technology Jodhpur
2010
Council of Scientific and Industrial Research
2008
Significance NO exposure triggered an ATM-mediated damage response in breast cancer cells involving activation of the LKB1 and TSC2 tumor suppressors, repression mTORC1, ULK phosphorylation, increased autophagic flux. The associated loss cell viability indicates that autophagy can function as a cytotoxic to nitrosative stress cells. Collectively, data identify nitrosative-stress signaling pathway regulates autophagy. A more comprehensive understanding pathways regulating holds promise for...
The perpetuity of cancer prevalence at a global level calls for development novel therapeutic approaches with improved targetability and reduced adverse effects. Conventional treatments have multitude limitations such as nonselectivity, invasive nature, severe Chemotherapy is also losing its efficacy because the multidrug resistance in majority cancers. To address these issues, selective targeting-based are being explored an effective treatment. Mitochondria, moderator crucial cellular...
In recent years, the use of silver nanoparticles (AgNPs) in biomedical applications has shown an unprecedented boost along with simultaneous expansion rapid, high-yielding, and sustainable AgNP synthesis methods that can deliver particles well-defined characteristics. The present study demonstrates potential metal-tolerant soil fungal isolate Penicillium shearii AJP05 for protein-capped AgNPs. were characterized using standard techniques, namely, UV–visible spectroscopy, transmission...
In this article, we tried to redefine the unexplored potential of a benzothiazole type Schiff-base (OM), which was identified as an AIE-active molecule that exhibits excited-state intramolecular proton transfer (ESIPT). Interestingly, compound shows ultra-sensitivity and selectivity in detection Al(iii) (12 pM; 456 ppt). The OM capable pH sensing also tested for internalization cancerous cells intracellular imaging. Computational modeling performed results were good agreement with...
Hepatocellular carcinoma (HCC) typically develops in a chronic inflammatory setting causal to release of plethora growth factors and cytokines. However, the molecular effect these cytokines on HCC progression is poorly understood. In this study, we exposed cells TGF-β2 (Transforming Growth Factor-β2), which resulted significant elevation EMT (Epithelial Mesenchymal Transition) like features. Molecular analysis markers showed an increase at both RNA protein levels upon administration along...
Melanoma patients experience inferior survival after biochemotherapy when their tumors contain numerous cells expressing the inducible isoform of NO synthase (iNOS) and elevated levels nitrotyrosine, a product derived from NO. Although several lines evidence suggest that promotes tumor growth increases resistance to chemotherapy, it is unclear how shapes these outcomes. Here we demonstrate modulation NO-mediated S-nitrosation cellular proteins strongly associated with pattern response...
Abstract Background Osteosarcoma (OS) is a malignant tumor of the bone mostly observed in children and adolescents. The current treatment approach includes neoadjuvant adjuvant chemotherapy; however, drug resistance often hinders therapy OS patients. Also, post-relapse survival patients as low 20%. We therefore planned to understand molecular cause for its poor prognosis design an appropriate therapeutic strategy combat disease. Methods analyzed patient dataset from Gene Expression Omnibus...
Breast cancer is one of the most frequent forms cancer. Although different treatment modalities are available, none has proved to be a game-changer. In this context, nanomedicine hot research areas, with nano-formulations being explored as therapeutic strategy against breast Herein, silver nanoparticles (AgNPs) have shown prospects their anti-tumor properties and currently aggressively; however, underlying molecular mechanisms AgNP action remain unearthed. As part study, human cells- MCF7...
Hypoxia-inducible factor-1α (HIF-1α) is a critical regulator of cellular responses to hypoxia. Under normoxic conditions, the HIF-1α level regulated by hydroxylation prolyl hydroxylases (PHDs), ubiquitylation, and proteasomal degradation. During hypoxia, degradation decreases, its intracellular increased. Exogenously administered nitric oxide (NO)-donor drugs stabilize HIF-1α; thus, NO suggested mimic However, role low levels endogenously produced generated during hypoxia in stabilization...
Abstract Cancer complexome comprises a heterogeneous and multifactorial milieu that varies in cytology, physiology, signaling mechanisms response to therapy. The combined framework of network theory spectral graph along with the multilayer analysis provides comprehensive approach analyze proteomic data seven different cancers, namely, breast, oral, ovarian, cervical, lung, colon prostate. Our demonstrates protein-protein interaction networks normal cancerous tissues associated cancers have...
Typical aggregation-induced emission (AIE) luminogens tetraphenylethylene (TPE) and triphenylamine have been used to construct an AIE-active conjugated polymer, namely, poly(N,N-diphenyl-4-(4-(1,2,2-triphenylvinyl)styryl)aniline) (PTPA), which consist of D-π-A architecture by Wittig polymerization. We fabricated mesoporous silica hollow nanospheres (MSHNs) were encapsulated with the polymer for applications in cellular imaging. It exhibits a positive solvatochromism effect increasing solvent...
Abstract Cancer is a complex disease with fatal outcome. Early detection of cancer, by monitoring appropriate molecular markers very important for its therapeutic management. In this regard, the short non-coding RNA molecules, microRNAs (miRNAs) have shown great promise due to their availability in circulating fluids facilitating non-invasive cancer. study, an silico comparative analysis was performed identify specific signature miRNAs dysregulated across multiple carcinomas and...
Synthesized two new bis-cyclometalated iridium(<sc>iii</sc>) complexes exhibiting strong AIE, studied their luminescence by spectroscopy and quantum chemical calculations applied as a non-toxic bio-imaging probe for mitochondrial staining.
Osteosarcoma (OS) is an aggressive bone malignancy commonly observed in children and adolescents. Sub-optimal therapy for years has irretrievably compromised the chances of OS patient survival; also, lack extensive research on this rare disease hindered therapeutic development. Cisplatin, a common anti-tumor drug, currently integral part treatment regime along with methotrexate doxorubicin. However, toxicity issues associated combination module impede therapy. Also, despite proven benefits...
Abstract Hypoxia triggers activation of platelets, leading to thrombosis. If not addressed clinically, it can cause severe complications and fatal consequences. The current treatment regime for thrombosis is often palliative include long-term administration anticoagulants, causing over-bleeding risk other secondary effects as well. This demands a molecular understanding the process exploration an alternative therapeutic avenue. Interestingly, recent studies demonstrate that platelets exhibit...
Three strong solid state emissive cyclometalated platinum(<sc>ii</sc>) complexes showing AIE property were synthesized and the feasibility of one dyes for cell imaging was reported.