A5106573329- Acute Myeloid Leukemia Research
- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Glioma Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Neutropenia and Cancer Infections
- RNA modifications and cancer
- Meningioma and schwannoma management
- Advanced X-ray and CT Imaging
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Polyomavirus and related diseases
- Tuberculosis Research and Epidemiology
- PI3K/AKT/mTOR signaling in cancer
- Occupational and environmental lung diseases
- Child Abuse and Trauma
- Sarcoma Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Metabolism, Diabetes, and Cancer
- Peripheral Nerve Disorders
- Autoimmune and Inflammatory Disorders Research
- Veterinary Orthopedics and Neurology
- Dermatological and COVID-19 studies
- Genetic Associations and Epidemiology
Deyang Stomatological Hospital
2025
Beijing Information Science & Technology University
2025
Xinqiao Hospital
2017-2024
Army Medical University
2010-2024
Chongqing Medical University
2018-2024
Sichuan University
2024
West China Hospital of Sichuan University
2024
Second Affiliated Hospital of Chongqing Medical University
2018-2021
Dalian Medical University
2018-2021
Daping Hospital
2010-2020
Abstract Objective. Metal artifacts seriously deteriorate CT image quality. Current metal reduction methods suffer from insufficient correction or easily introduce secondary artifacts. To better suppress artifacts, we propose a sinogram completion approach extracting and utilizing useful information that contained in the corrupted trace projections. Approach. Our method mainly contains two stages: interpolation by an improved normalization technique for initial physics-informed nonlinear...
Abstract Background Etripamil nasal spray (NS) is a fast-acting, intranasally administered calcium-channel blocker being developed for paroxysmal supraventricular tachycardia (PSVT). This Phase 3, multi-center, randomized, double-blind, placebo-controlled study aimed to evaluate the efficacy and safety of etripamil, self-administered by Chinese patients terminate PSVT in an at-home setting as prompted their symptoms PSVT. Methods Patients were ≥18 years age with prior...
The diagnostic and prognostic evaluation of primary central nervous system lymphoma (PCNSL) is challenging due to the lack sensitive biomarkers. present study aimed evaluate value interleukin (IL)‑10 in this context. Between October 2016 December 2018, 91 patients with suspected intracranial neoplasms were recruited, concentrations IL‑10 or IL‑6 both cerebrospinal fluid (CSF) blood measured analyzed by Kruskal‑Wallis test. correlation between CSF levels tumor size was determined Spearman's...
Abstract Although TC2N has proven to be an oncogene in lung cancer, its biological function and molecular mechanisms other cancer still remains unclear. Here, we investigate breast that expression is sharply overexpressed specimens compared with normal specimens, the low was associated advanced stage, lymphatic metastasis, larger tumors shorter survival time. Upregulation of significantly restrains cell proliferation vitro tumor growth vivo. Mechanistically, blocks AKT signaling a PI3K...
Refractory and relapsed acute myeloid leukemia (r/rAML) is associated with a difficult prognosis; clinical trials are typically suggested despite lack of recognized standard care. Combinatorial chemotherapy regimens utilized for r/rAML salvage play crucial role in battling this invasive phase. Although it characterized by low response rate, CLAG traditional regimen used r/rAML. We aimed to compare the efficacy toxicity CLAG+PLD explore whether there was any improvement addition pegylated...
Abstract Rationale: The diagnosis of hematological malignancies depends on laboratory analysis and often requires multiple experimental methods to judge, otherwise misdiagnosis is apt happen. Lymph node biopsy immunohistochemistry (IHC) for T-lymphoblastic lymphoma (T-LBL) the establishment antibody set screening. For identifying T-LBL early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) by lymph IHC, WHO has not yet proposed a better IHC combination. Patient concerns: Here we...
Increasing evidence has demonstrated that plasmacytoid dendritic cells (PDCs) in the tumor microenvironment (TME) play an important role tumorigenesis and progression. PDC infiltration been found certain malignancies such as classic Hodgkin's lymphoma chronic myelomonocytic leukemia. Our previous work reported could occur acute myeloid leukemia (AML), but clinical significance of AML not thoroughly investigated.Here, we evaluated to transition a microenvironment. The frequency PDCs 80...
ADHD and anxiety disorders often co-occur, sharing symptoms dysfunctions, yet the underlying mechanisms remain elusive.
The mobilization of hematopoietic stem cells (HSCs) using granulocyte colony-stimulating factor is a classic method. Recently, single injection pegfilgrastim was used to mobilize CD34+ in some small-sample studies. To confirm the efficacy and safety from healthy donors, we conducted retrospective multicenter study. A total 146 donors who all received subcutaneous (12 mg) on day 1 were enrolled our Donor HSC apheresis 5. primary endpoint percentage whom ≥4 × 106 cells/kg collected session....
Peroxisome proliferator-activated receptor alpha (PPARA) has been suggested as a therapeutic target for chronic lymphocytic leukemia (CLL). However, the underlying molecular mechanism remains largely unclear. In this study, we analyzed DNA next-generation sequencing (NGS) data and clinical information from 86 CLL patients to identify gene markers related treatment-free survival (TFS) length. We then constructed genetic network that includes promoters, treatment targets, TFS-related marker...
Background This study assesses the impact of adverse childhood experiences (ACEs) on cognitive function older adults. Furthermore, it examines potential underlying mechanism involving education level and subjective “feeling loneliness” (FOL). Methods Analyzing a population-based cohort sample from China Health Retirement Longitudinal Study database, 8,365 subjects aged 45 or were interviewed in 2018. Ten ACEs indicators measured using life history questionnaires assessed at 2014. FOL was...
CT angiography-source image (CTA-SI) can be used as an effective alternative to diffusion-weighted imaging (DWI) for identifying acute ischemic stroke (AIS). This study investigates the reliability of combining CTA-SI with non-contrast (NCCT) AIS diagnosis, a focus on how different brain areas affect diagnostic accuracy.
Topic: 6. Chronic lymphocytic leukemia and related disorders - Clinical Background: Time-to-first treatment (TTFT) may be an important endpoint for treatment-naive chronic (CLL) patients since it can help to idntify early drives of disease. TTFT is not affected by treatment-induced clonal evolution, which reflects the intrinsic biology disease heterogeneity better[1-3]. Aims: Prognostic analysis gene mutations in newly diagnosed CLL who have a shorter TTFT, tried find more predictive driving...
Background: Target protein positive of Leukemic cells is the key to success CAR T cell therapy. The expression target proteins in tumor usually evaluated by flow cytometry, and percentage CD antigen greater than 20 % considered as cutoff value cytometry. However, showed different fluorescence abundance (weak expression, homogeneous concentrated or heterogeneous continuous expression). Mean Fluorescence Intensity (MdFI) not strictly required for evaluating response CAR-T Whether difference...