Alcoholic liver injury is mainly caused by long-term excessive alcohol consumption and has become a global public threat to human health. It well known that Ganoderma lucidum excellent beneficial effects on function lipid metabolism. The object of this study was investigate the hepatoprotective ganoderic acid A (GAA, one main triterpenoids in G. lucidum) against alcohol-induced reveal underlying mechanisms its protective effects. results showed oral administration GAA significantly inhibited...

Attachment to cellular surfaces is a major attribute among infectious pathogens for initiating disease pathogenesis. In viral infections, viruses exploit receptor-ligand interactions latch onto exterior prior subsequent entry and invasion. light of the selective binding affinity between cells, nanoparticles cloaked in membranes are herein employed virus targeting. Using influenza as model, erythrocyte membrane prepared modified with magnetic functionalities (RBC-mNP) targeting isolation. To...

Feline infectious peritonitis (FIP), caused by a mutated feline coronavirus, is one of the most serious and fatal viral diseases in cats. The disease remains incurable, there no effective vaccine available. In light pathogenic mechanism coronavirus that relies on endosomal acidification for cytoplasmic entry, novel vacuolar ATPase blocker, diphyllin, its nanoformulation are herein investigated their antiviral activity against type II virus (FIPV). Experimental results show diphyllin...

Levilactobacillus brevis FZU0713, a potential probiotic previously isolated from the traditional brewing process of Hongqu rice wine, may have beneficial effects on improving lipid metabolism. This study aimed to evaluate in vivo protective and possible mechanism L. FZU0713 disturbance metabolism hyperlipidemic rats fed high-fat diet (HFD). Results showed that oral administration could significantly inhibit obesity, ameliorate disorder, including serum/liver biochemical parameters hepatic...

Androgen and its receptor (AR) have been reported to pro- or antiapoptotic functions. However, the underlying molecular mechanism is incompletely understood. We report here that androgen AR promote Bax-mediated apoptosis in prostate cancer cells. UV irradiation ectopic expression of Bax induce AR-positive, but not AR-negative UV- Bax-induced abrogated AR-positive cells express small interference RNA (siRNA) sensitized by reintroduction into Although able independently androgen, promotion can...

Abstract Ovarian cancer is currently one of the most common cancers female reproductive organs, and its mortality rate highest among all types gynecologic cancers. Rapid accurate classification ovarian plays an important role in determination treatment plans prognoses. Nevertheless, commonly used method based on histopathological specimen examination, which time‐consuming labor‐intensive. Thus, this study, we utilize radiomics feature extraction methods automated machine learning tree‐based...

Literature about healthcare-associated infection (HCAI) in China is scarce. A cross-sectional anonymous survey was conducted on 647 clinicians (199 physicians and 448 nurses) from six Shanghai hospitals (grades A–C) to investigate their cognizance, knowledge, attitude, self-reported practice, risks regarding HCAI with emphasis precautions. The mean overall score of knowledge 40.89±11.4 (mean±SD; range, 13∼72) out 100 for 43.48±9.9 (10∼70) nurses. respondents generally received high scores...

Acute pancreatitis (AP)‑associated lung injury (ALI) is a critical complication of AP. Adropin regulatory protein immune metabolism. The present study aimed to explore the immunomodulatory effects adropin on AP‑ALI. For this purpose, serum samples patients with AP were collected and expression levels detected using ELISA. Animal models knockout (Adro‑KO) constructed, in tissues was investigated. fibrosis apoptosis evaluated hematoxylin eosin staining, Masson's staining immunohistochemistry...

The signaling cascades of the mitogen activated protein kinase (MAPK) family, calcineurin/NFATc4, and PI3K/Akt/GSK3, are believed to participate in endothelin-1 (ET-1)-induced cardiac hypertrophy. aim this study was investigate whether KMUP-1, a synthetic xanthine-based derivative, prevents cardiomyocyte hypertrophy induced by ET-1 elucidate underlying mechanisms. We found that H9c2 cardiomyocytes, stimulation with (100 nM) for 4 days cell enhanced expressions hypertrophic markers, including...

Vigna radiata (L.) R. Wilczek (mung bean) is a Chinese functional food with antioxidant, antimicrobial and anti-inflammatory activities. However, little known about its antiviral activity. We aimed to investigate the activity mechanisms of action extract (VRE) against influenza virus. HPLC was conducted analyze components VRE. The anti-influenza viral VRE in Mardin-Darby canine kidney (MDCK) cells evaluated by virus titration assays, hemagglutination quantitative RT-PCR cellular α...

This study aimed to assess the clinical utility of advanced lung cancer inflammation index (ALI) as a prognostic indicator for patients with cholangiocarcinoma (CCA) and construct nomogram based on ALI.

Hematoxylin and eosin (H&E) staining of tissue samples is the standard approach in histopathology for imaging diagnosing cancer. Recent reports have shown that multiphoton microscopy (MPM) provides better sample interface with single-cell resolution, which enhances traditional H&E offers a powerful diagnostic tool potential applications oncology. The purpose this study was to further expand versatility MPM by establishing optical parameters required unstained histological sections pancreatic...

To evaluate hepatic recurrence and prognostic factors for survival in patients with surgically resected hilar cholangiocarcinoma a single institution over the last 13 years.From 1994 to 2007, all referred surgical clinic were evaluated. Demographic data, tumor characteristics, outcome analyzed retrospectively. Outcome was compared who underwent additional liver resection of tumor.Of 69 submitted laparotomy resection, curative (R(0) resection) performed 40 patients, palliative 29. Thirty-one...

Iron (Fe) deficiency is one of the most common micronutrient imbalances limiting plant growth globally, especially in arid and saline alkali regions due to decreased availability Fe alkaline soils. Malus halliana grows well tolerant deficiency. Here, a physiological metabolomic approach was used analyze short-term molecular response M. roots On hand, data show that root activity first increased then with prolongation stress time, but change trend pH just opposite. The total content...

Complete surgical resection is the only option for improving survival of patients with ductal adenocarcinoma in pancreatic head. After resection, determining status margins (RMs) crucial deciding on nature follow-up treatment. The purpose this study was to evaluate whether multiphoton microscopy (MPM) could be considered a reliable tool neck by identifying tumour cells these head, and our results were affirmative. In particular, MPM identify nerves. It also found that quantification...

Cystatin 2 (CST2) is a protein coding gene that belongs to large superfamily of cysteine protease inhibitors. The deregulation CST2 has been implicated in human cancers. role pancreatic carcinogenesis not yet investigated. In this study, Gene Expression Profiling Interactive Analysis was performed using the Cancer Genome Atlas (TCGA) dataset containing tumor samples and normal tissues. functional cells investigated by knockdown vitro mouse xenograft model. We found overexpressed cell lines....

The prognostic value of the genotype PRSS1 gene in patients with pancreatic ductal adenocarcinoma (PDAC) remains poorly understood. aim present study was to evaluate association between and clinicopathological characteristics PDAC, as well explore significance PDAC. A total 124 PDAC were included current enrolled determined by polymerase chain reaction. Associations subsequently analyzed using Chi‑square test. impact on patient prognosis assessed Kaplan‑Meier method, predictive factors...

Two-photon excited fluorescence (TPEF) microscopy has become a powerful instrument for imaging unstained tissue samples in biomedical research. The purpose of this study was to determine whether TPEF histological sections without hematoxylin-eosin (H-E) stain can be used characterize lesions and identify surgical margins pancreatic metastasis from renal cell carcinoma (RCC). specimens RCC, as well primary RCC patient, were examined by compared with their corresponding H-E stained...

Abstract Parvalbumin (PV)-positive interneurons modulate the processing of odor information. However, less is known about how PV dynamically remodel neural circuit responses in olfactory bulb (OB) and its physiological significance. This study showed that a reinforced discrimination task up-regulated activity ErbB4 kinase mouse OB. knock-out OB impaired dishabituation complex odors, whereas memory or adaptation had no alteration mice. RNAscope analysis demonstrated ErbB4-positive neurons are...