A5100373822- Genetic Mapping and Diversity in Plants and Animals
- Genomics and Chromatin Dynamics
- Genetic and phenotypic traits in livestock
- RNA Research and Splicing
- Plant Virus Research Studies
- Cancer-related molecular mechanisms research
- Plant Pathogens and Fungal Diseases
- MicroRNA in disease regulation
- Insect Resistance and Genetics
- Microbial Metabolism and Applications
- Insect-Plant Interactions and Control
- Muscle Physiology and Disorders
- Banana Cultivation and Research
- RNA modifications and cancer
- Genetic Syndromes and Imprinting
- Enzyme-mediated dye degradation
- Industrial Vision Systems and Defect Detection
- Autophagy in Disease and Therapy
- Advanced Power Generation Technologies
- Modeling, Simulation, and Optimization
- Natural product bioactivities and synthesis
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Chromium effects and bioremediation
- Immune Response and Inflammation
- Manufacturing Process and Optimization
First Affiliated Hospital of Anhui Medical University
2025
Anhui Medical University
2025
Yibin University
2023-2025
Sichuan Agricultural University
2018-2024
North China University of Science and Technology
2024
Tianjin Institute of Industrial Biotechnology
2024
Chinese Academy of Sciences
2024
Binzhou University
2024
ShanghaiTech University
2024
Ministry of Agriculture and Rural Affairs
2022-2023
Abstract Folliculogenesis is a complex biological process involving central oocyte and its surrounding somatic cells. Three-dimensional chromatin architecture an important transcription regulator; however, little known about dynamics role in transcriptional regulation of granulosa cells during chicken folliculogenesis. We investigate the transcriptomic over ten follicular stages assess how it influences gene expression at three key stages: prehierarchical small white follicles, first largest...
Guanidinoacetic acid (GAA), an amino derivative that is endogenous to animal tissues including muscle and nerve, has been reported enhance muscular performance. MicroRNA (miRNA) a post-transcriptional regulator plays key role in nutrient-mediated myogenesis. However, the effects of GAA on myogenic differentiation skeletal growth, potential regulatory mechanisms miRNA these processes have not elucidated. In this study, we investigated proliferation, differentiation, growth C2C12 cells mice....
Acute myocardial infarction (AMI) is an ischemic heart disease with high mortality worldwide. AMI triggers a hypoxic microenvironment and induces extensive injury, including autophagy apoptosis. MiRNAs, which are class of posttranscriptional regulators, have been shown to be involved in the development diseases. We previously reported that hypoxia significantly alters miRNA transcriptome rat cardiomyoblast cells (H9c2), miR-27a-5p. In present study, we further investigated potential function...
Brasenia schreberi is a widely consumed aquatic plant, yet the knowledge regarding its bioactive components, particularly polysaccharides, remains limited. Therefore, this study aimed to optimize extraction process of polysaccharides from B. using response surface method (RSM). Additionally, we characterized various methods and assessed their antioxidant capabilities both in vitro vivo, employing cell cultures Caenorhabditis elegans. Furthermore, these were incorporated into unique yogurt...
Stephania japonica is an early-diverging eudicotyledon plant with high levels of cepharanthine, proven to be effective in curing coronavirus infections. Here, we report a high-quality S. genome. The genome size 688.52 Mb, and 97.37% sequences anchor 11 chromosomes. comprises 67.46% repetitive 21,036 genes. It closely related two Ranunculaceae species, which diverged from their common ancestor 55.90–71.02 million years ago (Mya) whole-genome duplication 85.59–96.75 Mya. We further reconstruct...
The IL-13Rα1 signalling pathway and M2 macrophages play crucial roles in schistosome egg-induced hepatic fibrosis via the expression of pro-fibrotic molecules. This study aims to investigate inhibitory effect mechanism action corilagin on vitro vivo. mRNA protein IL-13Rα1, PPARγ, KLF4, SOCS1, STAT6, p-STAT6 TGF-β was measured with treatment after IL-13 stimulation vivo effectively killing adult schistosomes schistosome-infected mice. Histological analysis liver tissue assessed for degree...
Western flower thrips (Frankliniella occidentalis) are among the most important pests globally that transmit destructive plant viruses and infest multiple commercial crops. Lysine lactylation (Klac) is a recently discovered novel post-translational modification (PTM). We used liquid chromatography-mass spectrometry to identify global lactylated proteome of F. occidentalis, further enriched identified proteins using Kyoto Encyclopedia Genes Genomes (KEGG) Gene Ontology (GO). In present study,...
Using an adult female miniature pig model with diet-induced weight gain/weight loss, we investigated the regulatory mechanisms of three-dimensional (3D) genome architecture in adipose tissues (ATs) associated obesity. We generated 249 high-resolution situ Hi-C chromatin contact maps subcutaneous AT and three visceral ATs, analyzing transcriptomic architectural changes under different nutritional treatments. find that remodeling underpins divergence potentially linked to metabolic risks...
A growing body of evidence has revealed that the mammalian genome is organized into hierarchical layers are closely correlated with and may even be causally linked variations in gene expression. Recent studies have characterized chromatin organization various porcine tissues cell types compared them among species during early development pigs. However, how differs pig breeds poorly understood. In this study, we investigated 3D performed transcriptome characterization two adipose depots...
Plants and arbuscular mycorrhizal fungi (AMF) mutualistic interactions are essential for sustainable agriculture production. Although it is shown that AMF inoculation improves cassava physiological performances yield traits, the molecular mechanisms involved in AM symbiosis remain largely unknown. Herein, we integrated metabolomics transcriptomics analyses of symbiotic (Ri) asymbiotic (CK) roots explored AM-induced biochemical transcriptional changes.Three weeks (3w) after inoculations,...
Abstract Myofibres (primary and secondary myofibre) are the basic structure of muscle determinant mass. To explore skeletal developmental processes from primary myofibres to in pigs, we conducted an integrative three-dimensional genome transcriptomic characterization longissimus dorsi pig myofibre formation stage [embryonic Day 35 (E35)] (E80). In hierarchical genomic structure, found that 11.43% switched compartment A/B status, 14.53% topologically associating domains changed intradomain...
Liver development is a complex process that regulated by series of signaling pathways. Three-dimensional (3D) chromatin architecture plays an important role in transcriptional regulation; nonetheless, its dynamics and the rapid transition core liver functions during obesity-induced metabolic stress remain largely unexplored. To investigate dynamic under stress, we generated high-resolution maps for porcine livers across six major developmental stages (from embryonic day 38 to adult stage)...
Abstract The chicken provides large amounts of protein for the human diet and is also used as a model organism biomedical research. Increasing meat production an important goal in poultry industry skeletal muscles have highly diverse origins, shapes, metabolic features, physical functions. Previous gene expression atlases largely ignored differences among types muscles; therefore, comprehensive transcriptional maps all are needed to improve traits. In this study, we sequenced 58 samples from...
Pigeons (Columba livia) are among a select few avian species that have developed specialized reproductive mode wherein the parents produce 'milk' in their crop to feed newborn squabs. Nonetheless, transcriptomic dynamics and role rapid transition of core functions during 'lactation' remain largely unexplored. Here, we generated de novo pigeon genome assembly construct high resolution spatio-temporal landscape epithelium across entire breeding stage. This multi-omics analysis identified set...
Abstract Animal domestication is a long‐term, multistage process that results in modifications of many traits, especially the less aggressive behavior domesticated animals. In this study, we used Illumina RNA ‐seq to compare transcriptome brain frontal cortex between wild boar and Rongchang pig, typical indigenous domestic pig China, revealed 604 genes 639 were specifically detected respectively, with distinct functional characteristics may be related their respective environment. addition,...
Lentiviral vectors (LVs) are crucial tools in gene therapy and bioproduction, but high-yield LV production systems urgently needed. Using clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein 9 high-throughput screening, we identified nine critical genes (
Summary The potato virus Y (PVY) is a plant that causes massive crop losses globally, especially in Solanaceae crops. A strain of the growth‐promoting rhizobacterium (PGPR), Serratia marcescens ‐S3 was found to inhibit PVY replication Nicotiana benthamiana . However, there have been no in‐depth studies demonstrating underlying mechanism. In current study, we ubiquitination NbHsc70‐2 an important way for trigger induced systemic resistance (ISR). After treatment with S. ‐S3, protein level...