A5028022224- Genomics and Phylogenetic Studies
- Animal Nutrition and Physiology
- Cancer-related molecular mechanisms research
- Genetic and phenotypic traits in livestock
- Gut microbiota and health
- Genetic diversity and population structure
- MicroRNA in disease regulation
- Identification and Quantification in Food
- Muscle Physiology and Disorders
- Genetic Mapping and Diversity in Plants and Animals
- Circular RNAs in diseases
- RNA Research and Splicing
- Diet and metabolism studies
- interferon and immune responses
- Genomics and Chromatin Dynamics
- Livestock and Poultry Management
- Circadian rhythm and melatonin
- RNA modifications and cancer
- Genetics, Aging, and Longevity in Model Organisms
- Aquaculture disease management and microbiota
- Physiological and biochemical adaptations
- Animal Genetics and Reproduction
- Primate Behavior and Ecology
- Autophagy in Disease and Therapy
- Functional Brain Connectivity Studies
Chengdu University
2022-2025
Sichuan Agricultural University
2016-2025
Northwest A&F University
2025
First Affiliated Hospital of Xinjiang Medical University
2025
Xinjiang Medical University
2025
Soochow University
2021-2025
Huazhong University of Science and Technology
2025
Tongji Hospital
2025
Nanyang Technological University
2025
First Affiliated Hospital of Soochow University
2025
Musk, secreted by the musk gland of adult male musk-secreting mammals, holds significant pharmaceutical and cosmetic potential. However, understanding molecular mechanisms secretion remains limited, largely due to lack comprehensive multiomics analyses available platforms for relevant species, such as muskrat (Ondatra zibethicus Linnaeus) Chinese forest deer (Moschus berezovskii Flerov). We generated chromosome-level genome assemblies 2 species Flerov), along with 168 transcriptomes from...
Vertebrate Tas2r taste receptors bind to bitter compounds, which are typically poisonous, elicit sensation prevent the ingestion of toxins. Previous studies noted a marked variation in number genes among species, but underlying cause is unclear. To address this question, we compile gene repertoires from 41 mammals, 4 birds, 2 reptiles, 1 amphibian, and 6 fishes. The intact varies 0 bottlenose dolphin 51 Western clawed frog, with numerous expansions contractions family throughout vertebrates,...
Uncovering genetic variation through resequencing is limited by the fact that only sequences with similarity to reference genome are examined. Reference genomes often incomplete and cannot represent full range of diversity as a result geographical divergence independent demographic events. To more comprehensively characterize pigs ( Sus scrofa ), we generated de novo assemblies nine geographically phenotypically representative from Eurasia. By comparing them pig assembly, uncovered...
Alpha-ketoglutarate (AKG) is a key metabolite of the tricarboxylic acid (TCA) cycle, an essential process influencing mitochondrial oxidative respiration rate.Recent studies have shown that dietary AKG reduces mTOR pathway activation by inhibiting ATP synthase, thereby extending lifespan nematodes.Although also extends in fruit flies, antiaging mechanisms these organisms remain unclear.In present study, we explored changes gene expression associated with extension Drosophila mediated...
Previous neuroimaging studies have mainly focused on alterations of static and dynamic functional connectivity in patients with generalized anxiety disorder (GAD). However, the characteristics local brain activity over time GAD are poorly understood. This study aimed to investigate abnormal time-varying by using amplitude low-frequency fluctuation (ALFF) method combined sliding-window approach. Group comparison results showed that compared healthy controls (HCs), exhibited increased ALFF...
Abstract A comprehensive transcriptomic survey of pigs can provide a mechanistic understanding tissue specialization processes underlying economically valuable traits and accelerate their use as biomedical model. Here we characterize four transcript types (lncRNAs, TUCPs, miRNAs, circRNAs) protein-coding genes in 31 adult pig tissues two cell lines. We uncover the variability among 47 skeletal muscles, six adipose depots linked to different origins, metabolism, composition, physical...
Abstract The clinical misdiagnosis ratio of bipolar disorder (BD) patients to major depressive (MDD) is high. Recent findings hypothesize that the ability flexibly recruit functional neural networks differently altered in BD and MDD patients. This study aimed explore distinct aberrance network flexibility during dynamic configuration Resting state magnetic resonance imaging 40 patients, 61 matched healthy controls were recruited. Dynamic connectivity matrices for each subject constructed...
Abstract Folliculogenesis is a complex biological process involving central oocyte and its surrounding somatic cells. Three-dimensional chromatin architecture an important transcription regulator; however, little known about dynamics role in transcriptional regulation of granulosa cells during chicken folliculogenesis. We investigate the transcriptomic over ten follicular stages assess how it influences gene expression at three key stages: prehierarchical small white follicles, first largest...
Abstract Background The three-dimensional (3D) architecture of the genome has a highly ordered and hierarchical nature, which influences regulation essential nuclear processes at basis gene expression, such as transcription. While organization heterochromatin euchromatin can underlie differences in expression that determine evolutionary among species, way 3D is affected by forces within major lineages remains unclear. Here, we report comprehensive comparison genomes, using high resolution...
Abstract The vaginal microbiome plays an essential role in the reproductive health of human females. As infertility increases worldwide, understanding roles that may have and vitro fertilization (IVF) treatment outcomes is critical. To determine composition 1411 individuals (1255 undergoing embryo transplantation) their associations with outcomes, clinical biochemical features are measured, samples 16S rRNA sequenced. Our results suggest both too high low abundance Lactobacillus not...
The hypothalamic-pituitary-ovarian (HPO) axis represents a central neuroendocrine network essential for reproductive function. Despite its critical role, the intrinsic heterogeneity within HPO across vertebrates and complex intercellular interactions remain poorly defined. This study provides first comprehensive, unbiased, cell type-specific molecular profiling of all three components in adult Lohmann layers Liangshan Yanying chickens. Within hypothalamus, pituitary, ovary, seven, 12, 13...
Avian ovaries develop asymmetrically apart from prey birds, with only the left ovary growing more towards functional organ. Here, we analyze over 135,000 cells chick's and right at six distinct embryonic developmental stages utilizing single-cell transcriptome sequencing. We delineate gene expression patterns across 15 cell types within these embryo ovaries, revealing side-specific development. The exhibit cortex cells, zygotene germ transcriptional changes unique to side. Differential...
// Xiaolan Fan 1,* , Qing Liang Ting Lian 1 Qi Wu Uma Gaur Diyan Li Deying Yang Xueping Mao Zhihua Jin 2 Ying and Mingyao Animal Genetic Resources Exploration Innovation Key Laboratory of Sichuan Province, Agricultural University, Chengdu, P.R. China School Biotechnology Chemical Engineering, Ningbo Institute Technology, Zhejiang Zhejiang, * These authors have contributed equally to this work Correspondence to: Yang, email: Keywords : Drosophila, gut homeostasis, intestinal stem cell,...
Scope: Myogenesis involves a series of complex cellular and developmental processes regulated by many genes, transcription factors non-coding RNAs. Recent studies have demonstrated the involvement circular RNAs (circRNAs) in myogenesis. While previous established role for some circRNAs, precise functions mechanisms circRNAs skeletal muscle development are still not completely understood chicken. Methods: To identify potential during chicken embryonic development, rRNA- libraries sequencing...
Abstract Background Species living at high altitude are subject to strong selective pressures due inhospitable environments (e.g., hypoxia, low temperature, solar radiation, and lack of biological production), making these species valuable models for comparative analyses local adaptation. Studies that have examined high-altitude adaptation identified a vast array rapidly evolving genes characterize the dramatic phenotypic changes in animals. However, how environment shapes gene expression...
Abstract Male musk deer secrete from the gland located between their naval and genitals. Unmated male forest generate a greater amount of than mated males, potentially allowing them to attract number females. In this study, we used gas chromatography mass spectrometry (GC/MS) explore chemical composition pods captive unmated sexually mature Chinese next-generation sequencing intensively survey bacterial communities within them. Analysis showed that males have more muscone cholesterol....
Broodiness in laying hens results atrophy of the ovary and consequently decreases productivity. However, regulatory mechanisms that drive development remain elusive. Thus, we collected atrophic ovaries (AO) from 380-day-old broody chickens (BC) normal (NO) even-aged egg-laying (EH) for RNA sequencing. We identified 3,480 protein-coding transcripts were differentially expressed (DE), including 1,719 down-regulated 1,761 up-regulated AO. There 959 lncRNA DE, 56 903 up-regulated. Among the116...