A5101467734- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Genetic and phenotypic traits in livestock
- Adipose Tissue and Metabolism
- RNA Research and Splicing
- RNA modifications and cancer
- Muscle Physiology and Disorders
- Meat and Animal Product Quality
- Animal Nutrition and Physiology
- Genetic Mapping and Diversity in Plants and Animals
- Molecular Biology Techniques and Applications
- Adipokines, Inflammation, and Metabolic Diseases
- Kruppel-like factors research
- Gut microbiota and health
- Extracellular vesicles in disease
- Viral gastroenteritis research and epidemiology
- Muscle metabolism and nutrition
- Identification and Quantification in Food
- Peroxisome Proliferator-Activated Receptors
- GDF15 and Related Biomarkers
- Genomics and Phylogenetic Studies
- Sirtuins and Resveratrol in Medicine
- Endoplasmic Reticulum Stress and Disease
- Birth, Development, and Health
Sichuan Agricultural University
2016-2025
Ministry of Agriculture and Rural Affairs
2022-2025
Shenyang Pharmaceutical University
2023
East China Normal University
2022
Chengdu University
2020
Betaine is a natural compound present in commonly consumed foods and may have potential role the regulation of glucose lipids metabolism. However, underlying molecular mechanism its action remains largely unknown. Here, we show that supplementation with betaine contributes to improved high-fat diet (HFD)-induced gut microbiota dysbiosis increases anti-obesity strains such as
Uncovering genetic variation through resequencing is limited by the fact that only sequences with similarity to reference genome are examined. Reference genomes often incomplete and cannot represent full range of diversity as a result geographical divergence independent demographic events. To more comprehensively characterize pigs ( Sus scrofa ), we generated de novo assemblies nine geographically phenotypically representative from Eurasia. By comparing them pig assembly, uncovered...
Obesity is a major driver of metabolic diseases such as nonalcoholic fatty liver disease, certain cancers, and insulin resistance. However, there are no effective drugs to treat obesity. Betaine nontoxic, chemically stable naturally occurring molecule. This study shows that dietary betaine supplementation significantly inhibits the white fat production in high-fat diet (HFD)-induced obese mice. might be due preventing formation new (WAT), guiding original WAT burn through stimulated...
Abstract Background Increasing evidence shows that tRNA‐derived small RNAs (tsRNAs) are not only by‐products of transfer RNAs, but they participate in numerous cellular metabolic processes. However, the role tsRNAs skeletal muscle regeneration remains unknown. Methods Small RNA sequencing revealed relationship between and injury. The dynamic expression level 5'tiRNA‐Gly after injury was confirmed by real‐time quantitative PCR (q‐PCR). In addition, q‐PCR, flow cytometry,...
Abstract Skeletal muscle is the largest metabolic organ of human body. Maintaining best quality control and functional integrity mitochondria essential for health skeletal muscle. However, mitochondrial dysfunction characterized by dynamic imbalance mitophagy disruption can lead to varying degrees atrophy, but underlying mechanism action still unclear. Although dynamics are two different mechanisms, a large amount evidence has indicated that they interrelated mutually regulated. The former...
Intramuscular fat (IMF) content and composition are considered crucial indicators of porcine meat quality. However, the molecular mechanism IMF development is still mostly unclear. Recently, new evidence suggested that microRNA (miRNAs) play important roles in intramuscular adipogenesis. Previously, microRNA-125a-5p (miR-125a-5p) was identified as an regulator In present study, we found expression miR-125a-5p dynamically regulated during preadipocytes differentiation its levels different...
The carcass and meat quality traits of pig breeds living at three different altitudes (Yorkshire pigs, YP: 500m; Qingyu Pigs, QYP: 1500m; Tibetan TP: 2500m) were compared. It was observed that there are obvious differences in with respect to performance parameters. Specifically, YP had the best traits, showing high slaughter rates leanest meat. Conversely, QYP highest back fat thickness intramuscular (IMF) content. For high-altitude breed TP, animals exhibited low L* a* values. genotypes...
Genistein may regulate lipid metabolism in adipose tissue of obese mice by regulating the expression miR-222 and its target genes, BTG2 adipor1.
Spermatogenesis is temperature-dependent, and the increase in testicular temperature seriously affects mammalian spermatogenesis semen quality. In this study, heat stress model of mice was made with a 43 °C water bath for 25 min, effects on quality spermatogenesis-related regulators were analyzed. On 7th day after stress, testis weight shrank to 68.45% sperm density dropped 33.20%. High-throughput sequencing analysis showed that 98 microRNAs (miRNAs) 369 mRNAs down-regulated, while 77 miRNAs...
Abstract The objective of this study was to evaluate the effects muscle‐fibre types and hormones on glycolytic potential meat quality traits their association with glycolytic‐related gene expression in three different altitude pig breeds. breeds studied were Tibetan ( TP , high altitude), Liang‐Shan LSP middle altitude) D uroc × L andrace Y orkshire) cross DLY flatland). results indicated that had better than P < 0.01). GP ) increased order decreased time post mortem. higher glucagon...
(1) Background: Vitamin D (VD) plays a vital role in anti-viral innate immunity. However, the of VD anti-rotavirus and its mechanism is still unclear. The present study was performed to investigate whether alleviates rotavirus (RV) infection through microRNA-155-5p (miR-155-5p)-mediated regulation TANK-binding kinase 1 (TBK1)/interferon regulatory factors 3 (IRF3) signaling pathway vivo vitro. (2) Methods: efficacy treatment evaluated DLY pig IPEC-J2. Dual-luciferase reporter activity assay...
tRNA-derived fragments (tRFs) are a new class of non-coding RNA that play an important role in regulating cellular processing and protein translation. However, there is currently no study reporting the influence tRFs on myocardial hypertrophy. In this study, we used isoproterenol (ISO)-induced hypertrophy rat model. Small (<40 nts) transcriptome sequencing was to select differentially expressed tRFs. We also compared expression pattern F0 sperm hearts F1 offspring between group (Hyp)...
MicroRNAs (miRNAs), a class of small non-coding RNAs, have been proved as novel and potent regulators adipogenesis. A previous study has found out that miR-144-3p was biomarker type 2 diabetes, but the role in regulating adipogenesis still unclear. In present study, expression increased obese mice during 3T3-L1 differentiation process. Overexpression suppressed cell cycle regulatory factors inhibited pre-adipocytes proliferation. Besides, overexpression accelerated lipid accumulation...
tRNA-derived fragments (tRFs), a novel type of non-coding RNA derived from tRNAs, play an important part in governing gene expressions at post-transcriptional level. To date, the regulatory mechanism tRFs fat deposition and adipogenesis is completely unknown. In this study, high diet was employed to induce obese rat model, transcriptome sequencing conducted identify differentially expressed that response obesity. We found out tRFGluTTC, which promoted preadipocyte proliferation by increasing...
Polycystic ovary syndrome (PCOS) is an endocrine disorder characterized by hyperandrogenemia with multiple suspended sinus follicles, thickened cortical tissue, and excessive proliferation of ovarian granulosa cells that severely affects the fertility quality life women. The addition n-3 PUFA to diet may slightly reduce body weight greatly alleviate disturbed blood hormone levels in PCOS mice. We treated KGN as a cell model for showed inhibited GCs promoted ferroptosis cells. used CCK-8,...
Skeletal muscle is an important and complex organ with a variety of functions in humans animals. myogenesis multistep process, increasing evidence suggests that microRNAs (miRNAs) long noncoding RNAs (lncRNAs) play critical roles skeletal myogenesis. In this study the expression miR-351-5p dynamically regulated during vitro vivo. Cell-counting kit-8, qRT-PCR, EdU immunofluorescence analysis showed overexpression promoted proliferation inhibited differentiation C2C12 myoblast, whereas...