A5028743550- Genetic diversity and population structure
- Genomics and Phylogenetic Studies
- Solid State Laser Technologies
- Evolution and Genetic Dynamics
- Evolution and Paleontology Studies
- Laser Design and Applications
- Chromosomal and Genetic Variations
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Advanced Fiber Laser Technologies
- Machine Learning in Bioinformatics
- Animal Behavior and Reproduction
- Photorefractive and Nonlinear Optics
- Sperm and Testicular Function
- RNA and protein synthesis mechanisms
- Luminescence Properties of Advanced Materials
- Genetic and phenotypic traits in livestock
- Protein Structure and Dynamics
- Immune cells in cancer
- Single-cell and spatial transcriptomics
- Plant and animal studies
- Wildlife Ecology and Conservation
- Biosensors and Analytical Detection
- Advanced Biosensing Techniques and Applications
- Bat Biology and Ecology Studies
- Gene Regulatory Network Analysis
Institute of Zoology
2020-2025
Chinese Academy of Sciences
2017-2025
Central South University
2025
University of Chinese Academy of Sciences
2025
Institute of Zoology
2024
University of Michigan
2015-2020
Shanghai Institute of Ceramics
2017-2020
Evolutionary Genomics (United States)
2020
Peking University
2013-2019
Center for Life Sciences
2015-2019
Mechanistic understanding of the inhibitory immunoreceptor PD-1 is largely based on mouse models, but human and share only 59.6% amino acid identity. Here, we found that more than PD-1, owing to stronger interactions with ligands PD-L1 PD-L2 efficient recruitment effector phosphatase Shp2. In a melanoma model adoptively transferred T cells, humanization intracellular domain disrupted antitumor activity CD8
Musk, secreted by the musk gland of adult male musk-secreting mammals, holds significant pharmaceutical and cosmetic potential. However, understanding molecular mechanisms secretion remains limited, largely due to lack comprehensive multiomics analyses available platforms for relevant species, such as muskrat (Ondatra zibethicus Linnaeus) Chinese forest deer (Moschus berezovskii Flerov). We generated chromosome-level genome assemblies 2 species Flerov), along with 168 transcriptomes from...
Convergent and parallel amino acid substitutions in protein evolution, collectively referred to as molecular convergence here, have small probabilities under neutral evolution.For this reason, is commonly viewed evidence for similar adaptations of different species.The surge the number reports last decade raises intriguing question whether occurs substantially more frequently than expected evolution.We here address using all one-to-one orthologous proteins encoded by genomes 12 fruit fly...
Abstract Protein sequences contain rich information about protein evolution, fitness landscapes, and stability. Here we investigate how latent space models trained using variational auto-encoders can infer these properties from sequences. Using both simulated real sequences, show that the low dimensional representation of calculated encoder model, captures evolutionary ancestral relationships between Together with experimental data Gaussian process regression, also enables learning landscape...
Abstract Deciphering universal gene regulatory mechanisms in diverse organisms holds great potential for advancing our knowledge of fundamental life processes and facilitating clinical applications. However, the traditional research paradigm primarily focuses on individual model does not integrate various cell types across species. Recent breakthroughs single-cell sequencing deep learning techniques present an unprecedented opportunity to address this challenge. In study, we built extensive...
Abstract Phylogenetic trees reconstructed from molecular sequences are often considered more reliable than those morphological characters, in part because convergent evolution, which confounds phylogenetic reconstruction, is believed to be rarer for morphologies. However, neither the validity of this belief nor its underlying cause known. Here comparing thousands characters each type that have been used inferring phylogeny mammals, we find on average indeed experience much convergences amino...
Phylogenetic inference is of fundamental importance to evolutionary as well other fields biology, and molecular sequences have emerged the primary data for this task. Although many phylogenetic methods been developed explicitly take into account substitution models sequence evolution, such could fail due model misspecification or insufficiency, especially in face heterogeneities processes across sites among lineages. In study, we propose infer topologies four-taxon trees using deep residual...
While methodology for determining the mode of evolution in coding sequences has been well established, evaluation adaptation events emerging types phenotype data needs further development. Here we propose an analysis framework (expression variance decomposition, EVaDe) comparative single-cell expression based on phenotypic theory. After decomposing gene into separate components, use two strategies to identify genes exhibiting large between-taxon divergence and small within-cell-type noise...
It has been suggested that, due to the structure of genetic code, nonsynonymous transitions are less likely than transversions cause radical changes in amino acid physicochemical properties so on average deleterious. This view was supported by some but not all mutagenesis experiments. Because laboratory measures fitness effects have limited sensitivities and relative frequencies different mutations studies may match those nature, we here revisit this issue using comparative genomics. We...
The male-specific regions of primate Y-chromosomes (MSY) are enriched for multi-copy genes highly expressed in the testis. These located large repetitive sequences arranged as palindromes, inverted-, and tandem repeats termed amplicons. In humans, these have critical roles male fertility essential production sperm. structure human chimpanzee amplicon show remarkable difference relative to remainder genome, a that may be result intense selective pressure on fertility. Four subspecies common...
The South China tiger (Panthera tigris amoyensis) is endemic to and also the most critically endangered subspecies of living tigers. It considered extinct in wild only about 150 individuals survive captivity date, whose genetic heritage, however, ambiguous controversial. Here, we conducted an explicit assessment 92 studbook-registered tigers from 14 captive facilities using a subspecies-diagnostic system context comparison with other voucher specimens evaluate ancestry level distinctiveness...
Slavum lentiscoides and Chaetogeoica ovagalla are two aphid species from the subtribe Fordina of Fordini within subfamily Eriosomatinae, they produce galls on their primary host plants Pistacia. We assembled chromosome-level genomes these using Nanopore long-read sequencing Hi-C technology. A 332 Mb genome assembly S. with a scaffold N50 19.77 Mb, including 11,747 genes, 289 C. 11.85 containing 14,492 were obtained. The Benchmarking Universal Single-Copy Orthologs (BUSCO) benchmark...
Poaching and trans-boundary trafficking of tigers body parts are threatening the world's last remaining wild tigers. Development an efficient molecular genetic assay for tracing origins confiscated specimens will assist in law enforcement wildlife forensics this iconic flagship species. We developed a multiplex genotyping system "tigrisPlex" to simultaneously assess 22 short tandem repeat (STR, or microsatellite) loci gender-identifying SRY gene, all amplified 4 reactions using as little 1...
Long thought to be invariant, proteome-wide amino acid exchangeabilities in evolution actually vary widely among species.
The eye color of birds, generally referring to the iris, results from both pigmentation and structural coloration. Avian iris colors exhibit striking interspecific intraspecific variations that correspond unique evolutionary ecological histories. Here, we identified genetic basis pearl (white) in domestic pigeons (Columba livia) explore largely unknown mechanism underlying evolution avian Using a genome-wide association study (GWAS) approach 92 pigeons, mapped trait 9 kb region containing...
Conglobation is an adaptive behaviour occurring independently in various animal groups. Here, we study the evolution of conglobation Ceratocanthinae, a beetle group with ability to roll three body segments into tight ball. It here implied that this evolved only once Mesozoic. Evidence offered suggesting high defensive strength Ceratocanthinae due not spherical shape but also thickness and stronger mechanical properties dorsal cuticle. We further validate five characters including...
Several authors reported lower frequencies of protein sequence convergence between more distantly related evolutionary lineages and attributed this trend to epistasis, which renders the acceptable amino acids at a site different less likely in divergent lineages. A recent primate study, however, suggested that is least partially potentially entirely an artifact gene tree discordance (GTD). Here, we demonstrate genome-wide data set from 17 mammals temporal remains (1) upon control GTD level,...
3 at.%Yb: Sr1-xGdxF2+x (x = 0,0.01,0.03,0.06,0.09) single crystals are grown by the temperature gradient technique (TGT), where Gd3+ ions were used as a lattice structural modifier to form disordered site. The Yb: maintain cubic structure Fm3m. Specifically, absorption cross section of Sr0.97Gd0.03F2.03 crystal was increased more than 10% compared with that at.%Yb:SrF2. emission σem in 1.21 × 10−20 cm2 at central wavelength 976 nm an enhancement 11% A direct continuous-wave diode pumped...