A5101550749- Research in Cotton Cultivation
- Plant Molecular Biology Research
- Plant Reproductive Biology
- Polyoxometalates: Synthesis and Applications
- Reconstructive Facial Surgery Techniques
- Metal-Organic Frameworks: Synthesis and Applications
- Membrane Separation Technologies
- Ear Surgery and Otitis Media
- MicroRNA in disease regulation
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Cancer, Hypoxia, and Metabolism
- Nematode management and characterization studies
- Lanthanide and Transition Metal Complexes
- Membrane-based Ion Separation Techniques
- Nanocluster Synthesis and Applications
- Ear and Head Tumors
- Pancreatic function and diabetes
- Congenital Ear and Nasal Anomalies
- Plant Gene Expression Analysis
- Metalloenzymes and iron-sulfur proteins
- PARP inhibition in cancer therapy
- Nasal Surgery and Airway Studies
- Gene expression and cancer classification
Children's Hospital of Capital Institute of Pediatrics
2024
Beijing Jiaotong University
2024
Institute of Zoology
2024
Chinese Academy of Sciences
2024
Tsinghua University
2024
Nankai University
2024
Zhoukou Normal University
2023-2024
Zhengzhou University
2013-2023
Cotton Research Institute
2018-2023
Chinese Academy of Agricultural Sciences
2018-2023
Abstract Pancreatic ductal adenocarcinoma (PDAC) remains a huge challenge due to its high mortality and morbidity; gene therapy might be promising treatment for PDAC. The critical role of Wnt‐signaling pathway in cancer pathogenesis has been widely recognized; cyclin‐dependent kinase 14 (CDK14, PFTK1)‐induced low‐density lipoprotein receptor‐related proteins 5/6 (LRP5/6) phosphorylation is an important issue activation. Long noncoding RNA (LncRNA)‐microRNA (miRNA)‐messenger (mRNA) modulating...
Abstract Deciphering universal gene regulatory mechanisms in diverse organisms holds great potential for advancing our knowledge of fundamental life processes and facilitating clinical applications. However, the traditional research paradigm primarily focuses on individual model does not integrate various cell types across species. Recent breakthroughs single-cell sequencing deep learning techniques present an unprecedented opportunity to address this challenge. In study, we built extensive...
Pancreatic ductal adenocarcinoma (PDAC) remains a leading cause of cancer-related death due to the failure traditional therapies. In present study, we attempted construct lncRNA-miRNA-mRNA network which may modulate PDAC cell proliferation and Gemcitabine-induced apoptosis starting from CDK14, new member CDK family an oncogene in many cancers. Based on TCGA data, significant positive correlation was observed between lncRNA MSC-AS1 CDK14. Moreover, expression upregulated tissues. Higher...
Abstract: The antidiabetic drug metformin has been shown to possess antitumor functions in many types of cancers. Although studies have revealed its beneficial effects on the prognosis hepatocellular carcinoma (HCC), detailed molecular mechanism underlying this event remains largely unknown. In work, we showed that miR-23a was significantly induced upon treatment; inhibition abrogated proapoptotic effect HepG2 cells. We next established forkhead box protein A1 (FOXA1) as functional target...
Cotton (Gossypium spp.) is the most important natural textile fiber crop in world. The ideal plant architecture of cotton suitable for mechanical harvesting and productivity modern agricultural production. However, genes regulating development have not been fully identified. We identified a basic helix-loop-helix (bHLH) transcription factor, GhPAS1 (PAGODA1 SUPPRESSOR 1) G. hirsutum (Upland cotton). was located nucleus showed strong activation effect. Tissue-specific expression patterns that...
Pectin is a major polysaccharide component that promotes plant growth and fiber elongation in cotton. In previous studies, the galacturonosyltransferase-like (GATL) gene family has been shown to be involved pectin synthesis. However, few studies have performed on cotton GATL genes. Here, total of 33, 17, 16 genes were respectively identified Gossypium hirsutum, raimondii, arboreum. multiple species, phylogenetic analysis divided into five groups named GATL-a GATL-e, number was found...
Abstract Background The sequencing and annotations of cotton genomes provide powerful theoretical support to unravel more physiological functional information. Plant homeodomain (PHD) protein family has been reported be involved in regulating various biological processes plants. However, their studies have not yet carried out cotton. Results In this study, 108, 55, 52 PHD genes were identified G. hirsutum , raimondii arboreum respectively. A total 297 from three species, Arabidopsis rice...
Objective: To investigate the status quo of dietary nutrition knowledge, belief and behaviors patients with colorectal cancer undergoing radiotherapy, to analyze its influencing factors, so as provide basis for clinical management. Methods: a convenient sampling method was used select 200 who received radiotherapy in oncology department three Grade A hospitals Binzhou City from January May 2024 related study. questionnaire survey conducted on behavior total management respondents. In...
Cotton is one of the most important natural fibre resources in textile industry that has been cultivated to produce long and spinnable fibres. These cotton fibres are elongated single cells derived from outer epidermis ovules, which an ideal model study cell elongation plant kingdom (Lee et al., 2007). Phytohormones, such as brassinosteroid (BR), have also shown promote elongation. Additionally, many genes regulate functionally identified, especially transcription factors. Still, our...
Cysteine-rich receptor-like kinases (CRKs) play many important roles during plant development, including defense responses under both biotic and abiotic stress, reactive oxygen species (ROS) homeostasis, callose deposition programmed cell death (PCD). However, there are few studies on the involvement of CRK family in male sterility due to heat stress wheat ( Triticum aestivum L.). In this study, a genome-wide characterization was performed investigate structural functional attributes CRKs...
Six novel molybdenum hybrid materials based on a flexible multidentate ligand, namely (H3tib)4(β-Mo8O26)3·5H2O (1), (H3tib)2[Cu(H2O)2(γ-Mo8O26)2]·2H2O (2), [Cu(Htib)2(δ-Mo8O26)]·4H2O (3), [Cu2(tib)2(H2O)2(γ-Mo8O26)]·H2O (4), (H3tib)2[Co(H2O)2(γ-Mo8O26)2]·2H2O (5), and Zn(tib)(MoO4)·3H2O (6) (where tib = 1,3,5-tris(imidazol-1-ylmethyl)benzene), have been synthesized at different pH values under hydrothermal conditions. Their structures determined by single-crystal X-ray diffraction analysis...
Pancreatic cancer usually has a poor prognosis, and no gene therapy yet been developed that is effective to treat it. Since unique characteristic of bone marrow-derived mesenchymal stem cells (MSCs) they migrate tumor tissues, we wanted determine whether MSCs could serve as vehicle for targeting pancreatic cancer. First, successfully extracted from SD rats. Next, were efficiently transduced with NK4, an antagonist hepatocyte growth factor (HGF) which comprising the N-terminal subsequent four...
Ear amputations are common in emergency departments as the auricle's protrusion from lateral aspect of head makes it particularly susceptible to trauma. Of numerous approaches for auricle injuries, classic methods include microsurgical replantation, primary reattachment, composite graft, retroauricular pocket principle, secondary reconstruction with rib cartilage, and using postauricular flap. The success operation depends largely on choosing appropriate surgical procedure since many factors...
Chinese Baijiu has always been preferred by the majority of alcoholic drink lovers with its rich aroma. With popularity drinking culture and mental health, low-alcohol achieved increasing attention. This paper innovatively adopts coalescence method separating emulsion to solve turbidity problem in process degrading Baijiu. Firstly, characteristics feasible materials for removal via were explored. Three different pore size, chemical composition, wetting behavior, namely polyether sulfone...
Indoleamine 2, 3-dioxygenase (IDO) catalyzes the degradation of trytophan, which serves a key role in immune suppression via regulating production several metabolites. The present study aimed to explore effects and mechanisms IDO repair human airway epithelium suppressed by dexamethasone (DEX). Cell viability, proliferation migration were evaluated using Counting Kit-8 (CCK-8), 5(6)-carboxyfluorescein diacetate succinimidyl ester (CFSE) labeling, wound-healing assay, respectively. Reverse...
Chemotherapy and radiotherapy have been reported to be basically ineffective for pancreatic ductal adenocarcinoma patients; thus, gene therapy might provide a novel approach. CDK14, new oncogenic member of the CDK family involved in cancer cell response gemcitabine treatment, has regulated by microRNAs. In present study, we aimed investigate whether miR-26b CDK14 expression affect phenotype cells.Overexpression or knockdown was generated lines function on Wnt signaling pathway determined...