A5101508625- Immunotherapy and Immune Responses
- Cancer Cells and Metastasis
- Immune Cell Function and Interaction
- Urological Disorders and Treatments
- T-cell and B-cell Immunology
- Cancer, Hypoxia, and Metabolism
- Renal Transplantation Outcomes and Treatments
- Liver physiology and pathology
- Urinary Bladder and Prostate Research
- Global Cancer Incidence and Screening
- Chemokine receptors and signaling
- Drug Transport and Resistance Mechanisms
- Lung Cancer Diagnosis and Treatment
- Connective Tissue Growth Factor Research
- Drug-Induced Hepatotoxicity and Protection
- Lung Cancer Treatments and Mutations
- Endometrial and Cervical Cancer Treatments
- Renal and Vascular Pathologies
- Prostate Cancer Diagnosis and Treatment
- Biological and pharmacological studies of plants
- Pharmacological Effects of Natural Compounds
- Folate and B Vitamins Research
- Phytochemistry and Bioactivity Studies
- Cancer Immunotherapy and Biomarkers
- Congenital Heart Disease Studies
Qingdao University
2013-2024
Affiliated Hospital of Qingdao University
2023-2024
Southern Medical University
2003-2021
Kunming Medical University
2021
Zhujiang Hospital
2017-2021
Guizhou Provincial People's Hospital
2012-2020
China Three Gorges University
2019-2020
Xian Yang Central Hospital
2019-2020
Mayo Clinic in Florida
2020
Creative Commons
2019
Aims: Chlorogenic acid (CGA) is a phenolic that has wide range of pharmacological effects. However, the protective effects and mechanisms CGA on liver fibrosis are not clear. This study explored miR-21-regulated TGF-β1/Smad7 in hepatic stellate LX2 cell line CCl4-induced Sprague-Dawley rats. Methods: The mRNA expression miR-21, Smad7, connective tissue growth factor (CTGF), α-smooth muscle actin (α-SMA), inhibitor metalloproteinase 1 (TIMP-1), matrix metalloproteinase-9 (MMP-9), transforming...
Aims: Emodin is an anthraquinone with potential anti-inflammatory properties. However, the possible molecular mechanisms and protective effects of emodin are not clear. The objective this study was to investigate on lipopolysaccharide (LPS)-induced acute liver injury (ALI) via Toll-like receptor 4 (TLR4) signaling pathway in Raw264.7 cell line Balb/c mice. Methods: This established inflammatory cellular model induced ALI animal model. TLR4 overexpressed by lentivirus downregulated small...
Circulating tumor cells (CTCs) have been actively studied for their functions in hepatocellular carcinoma (HCC) recurrence. However, the relationship between circulating subtypes and recurrence is still unclear.
Background and Purpose The aim of this study was to investigate the ameliorative effects corilagin on intrahepatic cholestasis induced by regulating liver farnesoid X receptor (FXR)‐associated pathways in vitro vivo . Experimental Approach Cellular animal models were treated with different concentrations corilagin. In cellular experiments, FXR expression up‐regulated either lentiviral transduction or GW4064 treatment down‐regulated siRNA technology guggulsterones. Real‐time PCR Western...
This study investigated the antischistosomiasis liver fibrosis effects of chlorogenic acid (CGA) on interleukin 13 (IL-13)/microRNA-21 (miR-21)/Smad7 signaling interactions in hepatic stellate LX2 cell line and schistosome-infected mice. The transfection was based ability GV273-miR-21-enhanced green fluorescent protein (EGFP) GV369-miR-21-EGFP lentiviral system to up- or downregulate miR-21 gene cells. mRNA expression miR-21, Smad7, connective tissue growth factor (CTGF) CTGF, Smad1,...
Abstract Background Lung cancer is the second most common for men and women; wide adoption of electronic health records (EHRs) offers a potential to accelerate cohort-related epidemiological studies using informatics approaches. Since manual extraction from large volumes text materials time consuming labor intensive, some efforts have emerged automatically extract information lung patients natural language processing (NLP), an artificial intelligence technique. Methods In this study,...
// Jun Shang 1, * , Qian Song Zuyi Yang 2, Dongyao Li 1 Wenjie Chen Lei Luo Yongkun Wang Jingcheng and Shikang Department of Thoracic Cardiovascular Surgery, The First Affiliated Hospital Guangxi Medical University, Nanning 530021, P. R. China 2 Hematology, Soochow Suzhou 215006, These authors have contributed equally to this work Correspondence to: Li, email: shikangli@hotmail.com Yang, yjcyxky@163.com Keywords: RNA-seq, diagnosis, prognosis, lung adenocarcinoma Received: April 14, 2017...
The IL-13Rα1 signalling pathway and M2 macrophages play crucial roles in schistosome egg-induced hepatic fibrosis via the expression of pro-fibrotic molecules. This study aims to investigate inhibitory effect mechanism action corilagin on vitro vivo. mRNA protein IL-13Rα1, PPARγ, KLF4, SOCS1, STAT6, p-STAT6 TGF-β was measured with treatment after IL-13 stimulation vivo effectively killing adult schistosomes schistosome-infected mice. Histological analysis liver tissue assessed for degree...
Corilagin is a polyphenol that can be extracted from many medicinal plants and shows multiple pharmacological effects. We aimed to investigate the role of corilagin on miR-21-regulated hepatic fibrosis, especially TGF-β1/Smad signaling pathway, in stellate LX2 cell line Sprague-Dawley rats. The mRNA or protein levels miR-21, Smad7, connective tissue growth factor (CTGF), α-smooth muscle actin (α-SMA), inhibitor metalloproteinase-1 (TIMP-1), matrix metalloproteinase-9 (MMP-9), collagen type I...
This study was carried out to investigate the effect of Bletilla striata polysaccharide (BSP) treating on lipopolysaccharide (LPS)-induced intestinal epithelial barrier disruption in rat cell (IEC) line.LPS used stimulate IEC-18 cells (1 μg/ml), with or without different concentrations BSP (25, 50 and 100 μg/ml) for 24 h. Transepithelial electrical resistance (TEER) measured detect permeability cells. Interleukin-6 (IL-6) tumor necrosis factor-α (TNF-α) supernatant were detected...
It has been reported that intestinal epithelial barrier dysfunction serves an important role in the development of liver cirrhosis. However, at present there is no satisfactory treatment for mucosal lesions and ulcers associated with The aim study was to investigate effect Bletilla striata polysaccharide (BSP) on disruption rats thioacetamide (TAA)‑induced Rats were randomly divided into 5 groups (n=10): BSP low dosage (15 mg/kg), middle (30 high (60 experiment control groups. All except...
This study tried to explore whether corilagin would ameliorate or reverse the atherosclerotic development via toll-like receptor 4 (TLR4) signaling pathway in vitro and vivo. Ana-1 cells Mouse Peritoneal Macrophages (MPMs) were stimulated with ox-LDL followed by treating gradient of concentration. TLR4 expression was up-regulated lentiviral transduction down-regulated siRNA. Peripheral blood mononuclear (PBMCs), plasma samples femoral arteries collected from rat peripheral artery disease...
The purpose of this study is to characterize the re-epithelialization wound healing in canine prostatic urethra and evaluate effect way after two-micron laser resection prostate (TmLRP). TmLRP partial bladder neck mucosa were performed 15 healthy adult male crossbred canines. Wound specimens harvested at 3 days, 1, 2, 3, 4 weeks operation, respectively. histopathologic characteristics observed by hematoxylin eosin staining. expression cytokeratin 14 (CK14), CK5, CK18, synaptophysin (Syn),...
To examine the prevalence of dyslipidaemia in patients with renal cell carcinoma (RCC) a Chinese population.In all, 550 histologically confirmed RCC cases and 570 controls, matched for age sex were included. Total cholesterol, triglyceride, low-density lipoprotein (LDL) high-density (HDL) assessed before treatment using standard techniques. The lipid profiles defined as 'normal', 'borderline high', 'high' 'low' according to Guidelines on Adult Dyslipidaemia. Odds ratios (ORs) 95% confidence...
Tacrolimus (FK506) is associated with renal fibrosis in long-term use. Mycophenolatemofetil (MMF) can also inhibit or attenuate the progression of fibrosis. This study aimed to determine different effects FK506 and MMF on fibrosis-associated genes kidney rats that underwent chronic allograft nephropathy (CAN).Fisher (F344) kidneys were orthotopically transplanted into Lewis rat recipients. All recipients given Cyclosporin A (CsA) 10 mg/kg-1.d-1 × day then randomly divided three oral...
Conotruncal heart defects (CTDs) are a subgroup of congenital that considered to be the most common type birth defect worldwide. Genetic disturbances in folate metabolism may increase risk CTDs.We evaluated five single-nucleotide polymorphisms (SNPs) genes related folic acid metabolism: methylenetetrahydrofolate reductase (MTHFR C677T and A1298C), solute carrier family 19, member 1 (SLC19A1 G80A), methionine synthase (MTR A2576G), (MTRR A66G), as factors for CTDs including various types...