A5002198376- Phytochemistry and Bioactivity Studies
- Drug-Induced Hepatotoxicity and Protection
- Pharmacological Effects of Natural Compounds
- Ferroptosis and cancer prognosis
- Hepatitis B Virus Studies
- Cancer-related molecular mechanisms research
- Drug Transport and Resistance Mechanisms
- Parasites and Host Interactions
- RNA modifications and cancer
- Hepatitis C virus research
- MicroRNA in disease regulation
- Natural product bioactivities and synthesis
- Liver Disease Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Inflammasome and immune disorders
- Liver physiology and pathology
- Phytochemistry and Biological Activities
- Cancer Cells and Metastasis
- Glioma Diagnosis and Treatment
- Autophagy in Disease and Therapy
- Cancer Research and Treatments
- Nanoplatforms for cancer theranostics
- Catalytic Alkyne Reactions
- Neuroendocrine Tumor Research Advances
- Cell death mechanisms and regulation
Shandong Provincial Hospital
2025
Anhui Medical University
2023-2025
Soochow University
2020-2025
Jinan University
2009-2024
Huazhong University of Science and Technology
2015-2024
Union Hospital
2013-2024
Tianjin Institute of Industrial Biotechnology
2024
Chinese Academy of Sciences
2024
University of South China
2019-2024
Yanbian University Hospital
2023-2024
Ferroptosis is a newly recognized type of cell death, which different from traditional necrosis, apoptosis or autophagic death. However, the position ferroptosis in lipopolysaccharide (LPS)-induced acute lung injury (ALI) has not been explored intensively so far. In this study, we mainly analyzed relationship between and LPS-induced ALI.In human bronchial epithelial line, BEAS-2B, was treated with LPS ferrostatin-1 (Fer-1, inhibitor). The viability measured using CCK-8. Additionally, levels...
The metabolic regulation of cell death is sophisticated. A growing body evidence suggests the existence multiple checkpoints that dictate fate in response to fluctuations. However, whether microRNAs (miRNAs) are able respond stress, reset threshold death, and attempt reestablish homeostasis largely unknown. Here, we show miR-378/378* KO mice cannot maintain normal muscle weight have poor running performance, which accompanied by impaired autophagy, accumulation abnormal mitochondria,...
Transcription factor nuclear factor-erythroid 2-like 2 (NRF2) mainly regulates cellular antioxidant response, redox homeostasis and metabolic balance. Our previous study illustrated the translational significance of NRF2-mediated transcriptional repression, transcription FOCAD gene might be negatively regulated by NRF2. However, detailed mechanism related remain unclear. In this study, we explored effect NRF2-FOCAD signaling pathway on ferroptosis regulation in human non-small-cell lung...
Aims: Chlorogenic acid (CGA) is a phenolic that has wide range of pharmacological effects. However, the protective effects and mechanisms CGA on liver fibrosis are not clear. This study explored miR-21-regulated TGF-β1/Smad7 in hepatic stellate LX2 cell line CCl4-induced Sprague-Dawley rats. Methods: The mRNA expression miR-21, Smad7, connective tissue growth factor (CTGF), α-smooth muscle actin (α-SMA), inhibitor metalloproteinase 1 (TIMP-1), matrix metalloproteinase-9 (MMP-9), transforming...
Nowadays, treatments for cholestasis remain largely nonspecific and often ineffective. Recent studies showed that inflammatory injuries oxidative stress occur in the liver with cholestasis. In this study, we would use corilagin to treat animal model of acute order define activity interfere inflammation-related pathway cholestatic pathogenesis.Rats were administrated alpha-naphthylisothiocyanate establish divided into corilagin, ursodeoxycholic acid, dexamethasone, normal groups treatment...
Aims: Emodin is an anthraquinone with potential anti-inflammatory properties. However, the possible molecular mechanisms and protective effects of emodin are not clear. The objective this study was to investigate on lipopolysaccharide (LPS)-induced acute liver injury (ALI) via Toll-like receptor 4 (TLR4) signaling pathway in Raw264.7 cell line Balb/c mice. Methods: This established inflammatory cellular model induced ALI animal model. TLR4 overexpressed by lentivirus downregulated small...
Summary Emodin, an anthraquinone compound extracted from rhubarb and other traditional Chinese medicines, has been proven to have a wide range of pharmacological effects, such as anti-inflammatory, antiviral, antitumor activities. Previous studies confirmed that emodin inhibitory effects on various solid tumors, osteosarcoma, liver cancer, prostate cancer glioma. This study aimed investigate the mechanisms emodin-induced necroptosis in glioma cell line U251 by targeting TNF-α/RIP1/RIP3...
Abstract Ferroptosis is a novel type of programmed cell death, which different from apoptosis and autophagic death. Recently, ferroptosis has been indicated to contribute the in vitro neurotoxicity induced by isoflurane, one most common anesthetics clinic. However, vivo position isoflurane-induced as well learning memory impairment remains unclear. In this study, we mainly explored relationship between memory, therapeutic methods mouse model. Our results that isoflurane dose-dependent...
Abstract COX7A1, a subunit of cytochrome c oxidase, holds an important position in the super-assembly which integrates into multi-unit heteromeric complexes peripherally mitochondrial electron transport chain (ETC). Recently, some studies indicated significant potential COX7A1 cancer metabolism and therapy. However, underlying metabolic process therapy mechanism remain unclear. In this study, COX7A1-overexpressed cell line was established via lentivirus transduction. The relationship between...
Sepsis is one of the serious disorders in clinical practice. Recent studies found toll-like receptors 4 (TLR4) played an important role sepsis. In this study, we tried to find influence Corilagin on TLR4 signal pathways vitro and vivo.The cellular animal models sepsis were established by LPS then interfered with Corilagin. Real-time PCR western blot employed detect mRNA protein expressions TLR4, MyD88, TRIF TRAF6. ELISA was used determine IL-6 IL-1β levels supernatant serum.The survival rate...
<italic>In vivo</italic>and<italic>in vitro</italic>studies show that chlorogenic acid methyl ester (CME) has been proven to be a potential nutraceutical for preventing inflammation.
In this study, we aimed to reveal the resistance mechanism of hepatocellular carcinoma (HCC) cells sorafenib by exploring effect FNDC5 on sorafenib-induced ferroptosis in HCC cells. We compared expression level between sorafenib-resistant and sorafenib-sensitive cell lines groups after treatment with sorafenib. knocked down drug-resistant overexpressed it further demonstrate role ferroptosis. Using PI3K inhibitors, revealed specific which functions. addition, verified our findings obtained...