Valproic acid (2‐propylpentanoic acid, VPA) has been widely used as an anticonvulsant drug and is a choice for seizure treatment. VPA also short‐chain fatty HDAC inhibitor that affects proliferation differentiation induces cell apoptosis in both solid haematologic malignancies. Here, we observed treatment inhibited HDAC1/2 activity induced autophagy gastric cancer cells, leading to apoptosis. VPA‐induced occurred through inhibition of the HDAC1/PTEN/Akt signalling pathway involved...

Background & AimsThe protective intestinal mucosal barrier consists of multiple elements including mucus and epithelial layers immune defense; nonetheless, dysfunction is common in various disorders. The imprinted developmentally regulated long noncoding RNA H19 involved many cell processes diseases. Here, we investigated the role regulating Paneth goblet cells autophagy, its impact on induced by septic stress.MethodsStudies were conducted H19-deficient (H19-/-) mice, tissues from patients...

The DEK protein is related to chromatin reconstruction and gene transcription, plays an important role in cell apoptosis. High expression levels of the human have been correlated with numerous malignancies. This study explores roles tumor progression as a prognostic determinant colorectal cancer.Colorectal cancer specimens from 109 patients strict follow-up, adenomas 52 were selected for analysis by immunohistochemistry. correlations between over clinicopathological features cancers...

Abstract NQO1 is a FAD-binding protein that can form homodimers and reduce quinones to hydroquinones, growing body of evidence currently suggests dramatically elevated in solid cancers. Here, we demonstrated was breast cancer its expression level positively correlated with invasion reduced disease free survival (DFS) overall (OS) rates. Next, found β-lapachone exerted significant anti-proliferation anti-metastasis effects cell lines due on expression. Moreover, revealed the anti-cancer were...

Overexpression of NQO1 is associated with poor prognosis in human cancers including lung, stomach, colon, cervical, and pancreatic cancers. However, the molecular mechanisms underlying protumorigenic capacities have not been fully elucidated. Here, we investigated this question determined roles glycolysis reprogramming, proliferation, metastasis breast cancer (BC) cells. The results indicated that overexpression BC cells raises glucose metabolism related behaviors. Mechanistically, bound to...

Cervical cancer is the third most common in females worldwide. The treatment options for advanced cervical are limited, leading to high mortality. Ezrin a membrane-cytoskeleton-binding protein recently reported act as tumor promoter, and we previously indicated that aberrant localization overexpression of could be an independent effective biomarker prognostic evaluation cancers. In this study, identified regulator epithelial-mesenchymal transition (EMT) metastasis cancer. knock-down...

DEK, as an oncoprotein, plays important role in cancer development and progression. This study aimed to investigate the clinicopathological significance of DEK overexpression patients with gastric cancer.The expression protein was evaluated by immunohistochemical (IHC) staining 172 samples complete features, correlation between features examined. Survival rates were also calculated using Kaplan-Meier method survival data.DEK showed a strictly nuclear pattern cancers IHC immunofluorescence....

Non-small-cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide. NSCLC development and progression have recently been correlated with heightened activation histone deacetylases (HDACs) PI3K/Akt signaling pathways. Targeted inhibition these proteins promising approach for novel therapeutic strategies to treat patients advanced NSCLC. For this reason, we combined a dual PI3K mTOR inhibitor, BEZ235 HDAC inhibitor Trichostatin A (TSA), determine their effects on human...

Mortalin is a member of the heat shock protein 70 family, which involved in multiple cellular processes and may play key roles promoting carcinogenesis. This study attempted to identify clinical consequences overexpression its prognostic evaluation non–small cell lung cancer. A total 120 cancer samples paired with adjacent non-tumor tissue 10 normal tissues were selected for immunohistochemical staining Mortalin. The localization was detected A549 cells using immunofluorescence staining....

Intestinal Tuft cells sense luminal contents to influence the mucosal immune response against eukaryotic infection. Paneth secrete antimicrobial proteins as part of protective barrier. Defects in and occur commonly various gut disorders. MicroRNA-195 (miR-195) regulates stability translation target mRNAs is involved many aspects cell processes pathologies. Here, we reported posttranscriptional mechanisms by which miR-195 function small intestinal epithelium. Mucosal tissues from epithelial...

Abstract Background The glucose-6-phosphatase catalytic subunit (G6PC) is a key enzyme that involved in gluconeogenesis and glycogen decomposition during glycometabolism. Studies have shown G6PC abnormally expressed various cancers participates the proliferation metastasis of tumors. However, role cervical cancer remains poorly established. Methods To analyze expression tissues patients by immunohistochemistry. Effects deregulation on phenotype were determined using MTT, colony formation,...

Ezrin and YAP are abnormally expressed in various cancers, play pivotal roles cancer initiation development. However, the mechanisms of pancreatic have not been fully elucidated. In this study, we aimed to elucidate functions pathogenesis cancer.Effects deregulation on phenotype were determined Capan-1 BxPC-3 cells using MTT, colony formation, transwell, wound-healing, chick chorioallantoic membrane assays. To find out underlying mechanism Ezrin, multiple assays performed detect effect Akt...

Our previous study indicated that DEK protein was overexpressed in colorectal carcinoma (CRC) compared with the normal mucosa. also significantly correlated prognostic characteristics of patients CRC, demonstrating played an important role CRC progression. In this work, we evaluate effects on biological behaviors and explore related molecular mechanisms. The results showed human tissues, Ki-67 index apoptotic index. depletion by RNAi SW-620 HCT116 cells decreased cell proliferation, but...

Abstract Iron metabolism plays an important role in maintaining cellular multiple biological functions. Dysfunction of iron homeostasis-maintaining systems was observed many diseases, including cancer. Ribosomal L1 domain-containing 1 (RSL1D1) is RNA-binding protein involved processes, senescence, proliferation and apoptosis. However, the regulatory mechanism RSL1D1 underlying senescence its process colorectal cancer (CRC) not clearly understood. Here, we report that expression downregulated...

T-lymphoma invasion and metastasis-inducing protein 1 (Tiam1) has been implicated in tumor occurrence progression. Recent studies have shown that high expression levels of Tiam1 appear to be associated with the progression numerous human tumors. This study attempted explore role prognostic evaluation breast cancer.The localization was determined MDA-MB-231 cancer cell line using immunofluorescence (IF) staining. In addition, a total 283 tissue samples, including 153 tissues, 67 ductal...