A5101807325- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Adipose Tissue and Metabolism
- Genomics, phytochemicals, and oxidative stress
- Adipokines, Inflammation, and Metabolic Diseases
- Immune cells in cancer
- Nanoplatforms for cancer theranostics
- Ferroptosis and cancer prognosis
- Plant tissue culture and regeneration
- Plant Genetic and Mutation Studies
- Metabolism, Diabetes, and Cancer
- Liver Disease Diagnosis and Treatment
- EEG and Brain-Computer Interfaces
- Cancer-related gene regulation
- Ginseng Biological Effects and Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Thyroid Disorders and Treatments
- Advanced Photocatalysis Techniques
- Catalytic C–H Functionalization Methods
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Cancer, Lipids, and Metabolism
- Neuroscience of respiration and sleep
Southwest University
2021-2025
China Medical University
2014-2025
Second Military Medical University
2017-2025
Changhai Hospital
2020-2025
Hainan Medical University
2023-2025
Institute of Plant Protection
2025
State Key Laboratory of Pollution Control and Resource Reuse
2025
Nanjing University
2025
Sichuan Academy of Agricultural Sciences
2025
Tianjin University
2011-2024
A novel kind of quantum dots, sulfur dots (S dots), is synthesized by simply treating sublimated powders with alkali using polyethylene glycol-400 as passivation agents. The S exhibit excellent aqueous dispersibility, eminent photostability and temperature dependent photoluminescence (PL). An "assemble–fission" mechanism proposed for the formation in which "assembling" "fission" are involved contest each other. ultimate morphologies on balance two forces. Guided assemble–fission mechanism,...
Real-time sensing of nitric oxide (NO) in physiological environments is critically important monitoring neurotransmission, inflammatory responses, cardiovascular systems, etc. Conventional approaches for NO detection relying on indirect colorimetric measurement or built with rigid and permanent materials cannot provide continuous and/or require additional surgical retrieval the implants, which comes increased risks hospital cost. Herein, we report a flexible, biologically degradable...
Plant basic helix-loop-helix (bHLH) transcription factors play essential roles in abiotic stress tolerance. However, most bHLHs have not been functionally characterized. Here, we characterized the functional role of a bHLH factor from Arabidopsis, AtbHLH112, response to stress. AtbHLH112 is nuclear-localized protein, and its nuclear localization induced by salt, drought abscisic acid (ABA). In addition, serves as transcriptional activator, with activation domain located at N-terminus....
The metabolic regulation of cell death is sophisticated. A growing body evidence suggests the existence multiple checkpoints that dictate fate in response to fluctuations. However, whether microRNAs (miRNAs) are able respond stress, reset threshold death, and attempt reestablish homeostasis largely unknown. Here, we show miR-378/378* KO mice cannot maintain normal muscle weight have poor running performance, which accompanied by impaired autophagy, accumulation abnormal mitochondria,...
Abstract Maternally expressed gene 3 (MEG3), a long non-coding RNA (lncRNA), has tumor-suppressor properties and its expression is lost in several human tumors. However, biological role esophageal squamous cell carcinoma (ESCC) tumorigenesis poorly defined. The present study determined the methylation status of MEG3 cancer cells ESCC clinical specimens, further observed competing endogenous (ceRNA) activity pathogenesis development ESCC. Significant downregulation was detected tissues level...
Abstract Thyroid hormones (TH) regulate systemic glucose metabolism through incompletely understood mechanisms. Here, we show that improved in hypothyroid mice after T3 treatment is accompanied with increased glucagon-like peptide-1 (GLP-1) production and insulin secretion, while co-treatment a GLP-1 receptor antagonist attenuates the effects of on levels. By using lacking hepatic TH β (TRβ) liver-specific TRβ-selective agonist, demonstrate TRβ-mediated signalling required for both...
Abstract Current techniques for visualizing and quantifying cellular forces have limitations in live cell imaging, throughput, multi-scale analysis, which impede progress force research its practical applications. We developed a photonic crystal microscopy (PCCFM) to image vertical over wide field of view (1.3 mm ⨯ 1.0 mm, 10 objective image) at high speed (about 20 frames per second) without references. The hydrogel substrate (PCS) converts micro-nano deformations into perceivable color...
Regulator of G protein signaling 1 (RGS1) is known to be highly expressed in various tumors, but its specific effects and regulatory mechanism ovarian cancer (OC) progression are not well understood. To delve into the tumor biology, a predictive risk model for OC was developed, incorporating RGS1, PRKG2, CD24, ABCB1, with RGS1 exhibiting strongest correlation. The model's reliability validity were confirmed through Kaplan-Meier analysis, receiver operating characteristic (ROC) curve,...
Thiamethoxam (THM) is one of the most widely used insecticides globally, which was designed to selectively target nicotinic acetylcholine receptors (nAChRs) in insect nervous system and generally considered safe for non-targeted organisms. However, increasing evidence has demonstrated its neurotoxicity aquatic organisms, though underlying mechanisms, especially at environmentally relevant concentrations, remain largely unclear. In this study, swimming distance zebrafish significantly...
Diabetes is an independent risk factor for sudden cardiac death and ventricular arrhythmia complications of acute coronary syndrome. Prolongation the QT interval on electrocardiogram also a arrhythmias death, increased prevalence prolongation cardiovascular in diabetic patients. The pathophysiological mechanisms responsible this lethal complication are poorly understood. associated with reduction phosphoinositide 3-kinase (PI3K) signaling, which regulates action potential duration (APD)...
l-Arabinose is a monosaccharide extracted from plants or fibers, which known to have variety of functional properties. In this study, we aim investigate whether l-arabinose could inhibit colitis by modulating gut microbiota. was administered in mice daily dextran sodium sulfate (DSS)-induced model. The histological analysis, disease index, and the expression inflammatory genes were measured. 16S-rRNA sequence analysis performed Intriguingly, found that repress DSS-induced p38-/p65-dependent...
The neovascular form of age-related macular degeneration (nvAMD) is the leading cause blindness in elderly population. Vascular endothelial growth factor (VEGF) plays a crucial role choroidal neovascularization (CNV), and anti-VEGF therapy recommended as first-line for nvAMD. However, many patients do not radically benefit from this therapy. Epidemiological data suggest that physical exercise beneficial human diseases, including Yet, its protective mechanism therapeutic potential remain...
A highly organized transverse tubule (T-tubule) network is necessary for efficient Ca(2+)-induced Ca(2+) release and synchronized contraction of ventricular myocytes. Increasing evidence suggests that T-tubule remodeling due to junctophilin-2 (JP-2) downregulation plays a critical role in the progression heart failure. However, mechanisms underlying JP-2 dysregulation remain incompletely understood.A mouse model reversible failure driven by conditional activation heterotrimeric G protein Gαq...
Maternally expressed gene 3 (MEG3) is an imprinted located at 14q32 which encodes lncRNA and downregulated in expanding list of cancer cell lines primary human cancers. The miR-770 transcribed from the intronic sequence MEG3 may be host for miR-770. However, biological role gastric cardia adenocarcinoma (GCA) development prognosis poorly defined. present study was to investigate function methylation status GCA, further detect functional association its GCA carcinogenesis prognosis....
Chinese cabbage (Brassica rapa L. ssp. pekinensis) is a widely cultivated and economically important vegetable crop with typical leaf curvature. The TCP (Teosinte branched1, Cycloidea, Proliferating cell factor) family proteins are plant-specific transcription factors (TFs) play roles in many plant biological processes, especially the regulation of In this study, 39 genes encoding TFs detected on whole genome B. rapa. Based phylogenetic analysis TCPs between Arabidopsis thaliana Brassica...