A5101791653- Genomics and Chromatin Dynamics
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Genetic diversity and population structure
- Heparin-Induced Thrombocytopenia and Thrombosis
- Circular RNAs in diseases
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Phosphorus compounds and reactions
- Proteoglycans and glycosaminoglycans research
- RNA modifications and cancer
- Dendrimers and Hyperbranched Polymers
- Single-cell and spatial transcriptomics
- Genomics and Phylogenetic Studies
- Genetic Mapping and Diversity in Plants and Animals
Sichuan Agricultural University
2021-2023
Ministry of Agriculture and Rural Affairs
2023
Sichuan Animal Science Academy
2023
Central South University
2019
Jiangsu University of Technology
2015
Abstract Myofibres (primary and secondary myofibre) are the basic structure of muscle determinant mass. To explore skeletal developmental processes from primary myofibres to in pigs, we conducted an integrative three-dimensional genome transcriptomic characterization longissimus dorsi pig myofibre formation stage [embryonic Day 35 (E35)] (E80). In hierarchical genomic structure, found that 11.43% switched compartment A/B status, 14.53% topologically associating domains changed intradomain...
Liver development is a complex process that regulated by series of signaling pathways. Three-dimensional (3D) chromatin architecture plays an important role in transcriptional regulation; nonetheless, its dynamics and the rapid transition core liver functions during obesity-induced metabolic stress remain largely unexplored. To investigate dynamic under stress, we generated high-resolution maps for porcine livers across six major developmental stages (from embryonic day 38 to adult stage)...
Abstract Herein, we designed and developed a simple, rapid sensitive method for detection of coralyne heparin using singly labeled fluorescent probe, based on photoinduced electron transfer (PIET). A specific oligonucleotide strand was with fluorophore (6‐FAM) at its 5’ end four guanines 3’ end. In the presence coralyne, homo‐adenine DNA duplex is formed via 2 ‐coralyne‐A coordination, thus leading to fluorescence quenching due PIET between guanine fluorophore. Upon addition heparin,...
The performances of algorithms for Hi-C data preprocessing, the identification topologically associating domains, and detection chromatin interactions promoter–enhancer have been mostly evaluated using semi-quantitative or synthetic approaches, without utilizing most recent methods, since 2017. In this study, we comprehensively 24 popular state-of-the-art methods complete end-to-end pipeline analysis, manually curated experimentally validated benchmark datasets, including a CRISPR dataset...
Gene expression profiles of blood can reflect the physiopathologic status immune system. The dynamic microRNA (miRNA) peripheral from pigs at different developmental stages, and how differential miRNAs might relate to system development, are unknown. In this study, samples taken five stages were used construct 15 miRNA libraries (three biological replicates/stage): 0 days (newborn), 30 (weaning), 60 (weaned), 180 360 (puberty). We identified 295 known mature miRNAs. Hierarchical clustering...
苯甲酸及其衍生物; 接着和碘(NBS)发生环合反应, 生成 3-碘(溴
Genes undergo distinct selective sweeps, and also interact coevolve, forming the bases of complex phenotypic traits. Therefore, identification genes that coevolve or are under artificial sweeps is great importance. However, previous computational methods have been designed for either populations closely related breeds individuals species. Approaches intended specifically without replicate (i.e. each breed/strain represented by only one individual) long overdue. We present a free, powerful,...