A5100324061- Atherosclerosis and Cardiovascular Diseases
- Air Quality and Health Impacts
- Lung Cancer Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Climate Change and Health Impacts
- Lung Cancer Treatments and Mutations
- RNA modifications and cancer
- Radiomics and Machine Learning in Medical Imaging
- interferon and immune responses
- T-cell and B-cell Immunology
- Cytokine Signaling Pathways and Interactions
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Tuberculosis Research and Epidemiology
- SARS-CoV-2 and COVID-19 Research
- Respiratory Support and Mechanisms
- Immune Cell Function and Interaction
- Inflammatory mediators and NSAID effects
- Cancer-related molecular mechanisms research
- Adipokines, Inflammation, and Metabolic Diseases
- SARS-CoV-2 detection and testing
- Atmospheric chemistry and aerosols
- Aquaculture disease management and microbiota
- COVID-19 Clinical Research Studies
- Sarcoma Diagnosis and Treatment
China Medical University
2025
Shanghai Jiao Tong University
2004-2025
Bengbu Medical College
2024-2025
First Affiliated Hospital of Bengbu Medical College
2025
Third Affiliated Hospital of Sun Yat-sen University
2021-2025
Sun Yat-sen University
2021-2025
Second Affiliated Hospital of Zhejiang University
2025
University at Albany, State University of New York
2022-2024
People’s Hospital of Wenshan Prefecture
2024
Zhejiang University
2024
Abstract Recently, the recurrence of positive SARS-CoV-2 viral RNA in recovered COVID-19 patients is receiving more attention. Herein we report a cohort study on follow-up 182 under medical isolation observation. Twenty (10.99%) out were detected to be (re-positives), although none showed any clinical symptomatic recurrence, indicating that responds well treatment. Patients aged 18 years had higher re-positive rates than average, and severely ill re-tested positive. There no significant...
The corona virus disease 2019 (COVID-19) is a highly contagious caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). More than 18 million people were infected with total of 0.7 deaths in ∼188 countries. Controlling spread SARS-CoV-2 therefore inherently dependent on identifying and isolating individuals, especially since COVID-19 can result little to no symptoms. Here, we provide comprehensive review different primary technologies used test for infection, discuss...
Despite abundant evidence documenting the importance of TNF-alpha in pathogenesis pulmonary fibrosis, its actual role has not been fully elucidated. Recent observations also indicate that eosinophils found fibrotic lung express elevated levels cytokines known to be important fibrosis. These findings suggest a possible for eosinophil recruitment and cytokine expression this disease. To examine hypothesis, fibrosis was induced mice by endotracheal bleomycin treatment, separate groups animals...
Abstract Recent studies indicate that monocyte chemoattractant protein-1 (MCP-1) may play an important role in pulmonary inflammation. In vitro show a number of cell types are capable producing MCP-1. this study, MCP-1 expression lungs rats with bleomycin (BLM)-induced fibrosis is examined to evaluate its cellular origin and potential pathogenesis. Lung was induced male Fisher 344 by endotracheal injection on day 0. On selected days after injection, were harvested for situ Northern...
CD4⁺CD25⁺ regulatory T cells (Tregs) mediate immune suppression and prevent autoimmune disorders. Recently, Tregs were found to present in atherosclerotic lesions play an important role the progression of atherosclerosis. Statins have immunomodulatory properties, effect statins on atherosclerosis depends part their mechanisms. We sought determine whether exhibit plaques peripheral circulation patients with acute coronary syndrome (ACS). In vivo experiment, we induced apolipoprotein...
Strong infectivity enables coronavirus disease 2019 (COVID-19) to rage throughout the world. Moreover, lack of drugs with definite therapeutic effects further aggravates spread pandemic. Remdesivir is one most promising anti-severe acute respiratory syndrome 2 (SARS-CoV-2) drugs. However, limited clinical make its effect controversial, which may result from poor accumulation and activation remdesivir in lung. Therefore, we developed lyophilized liposomes (Rdv-lips) can be reconstituted as...
Abstract Background Respiratory muscle training is a continuous and standardized of respiratory muscles, but the evidence effects on early stroke patients not clear. This meta-analysis aimed to investigate function functional capacity in with stroke. Methods PubMed, Embase, PEDro, ScienceDirect, AMED, CINAHL, China National Knowledge Infrastructure databases were searched from inception December 8, 2023 for articles about studies that 1) age ≥ 18 years old. Early < 3 months at time...
Cordycepin is a component of the extract obtained from Cordyceps militaris and has many biological activities, including anti-cancer, anti-metastatic anti-inflammatory effects. Intervertebral disc degeneration (IDD) degenerative disease that closely related to inflammation nucleus pulposus (NP) cells. The effect cordycepin on NP cells in relation not yet been studied. In our study, we used rat cell culture an intervertebral (IVD) organ model examine inhibitory effects lipopolysaccharide...
Abstract The diverse repertoire of T cell receptors (TCR) and immunoglobulins is generated through the somatic rearrangement respective V, D J gene segments, termed V(D)J recombination, during early or B development. However, epigenetic regulation recombination still not fully understood. Here we show that deficiency Setd2, a histone methyltransferase catalyzes lysine 36 trimethylation on 3 (H3K36me3) in mice, causes severe developmental block thymocytes at CD4 − CD8 DN3 stage. While...
Abstract Osteoarthritis (OA) is a chronic degenerative disease of the bone and joints. Immune-related genes immune cell infiltration are important in OA development. We analyzed immune-related infiltrates to identify diagnostic markers. The datasets GSE51588, GSE55235, GSE55457, GSE82107, GSE114007 were downloaded from Gene Expression Omnibus database. First, R software was used differentially expressed (DEGs) (DEIRGs), functional correlation analysis conducted. Second, CIBERSORT evaluate...
Acute lung injury (ALI) is an inflammatory disease that caused by bacterial infection. Lipopolysaccharide (LPS), a prototype pathogen-associated molecular pattern (PAMP) from Gram-negative bacteria such as Escherichia coli (E. coli), essential risk factor for ALI. LPS and E. induced the activation of mitogen-activated protein kinase (MAPK) nuclear kappaB (NF-κB) signaling pathways, which led to increasing immune molecule transcription, including pro-inflammatory cytokine chemokine secretion....
Abstract Diabetic nephropathy (DN) is one of the major complications diabetes mellitus (DM). This study aimed to explore effects corosolic acid (CA) on renal damage DM and mechanisms behind these effects. The renoprotective effect CA was investigated in type 1 diabetic rats db/db mice. kidneys glomerular mesangial cells (GMCs) were used proliferation GMCs by immunostaining MTT assay. Further immunoblotting, siRNA, qPCR analysis detecting NADPH oxidase activity reactive oxygen species (ROS)...
Flexible sensing offers real-time force monitoring, presenting a versatile and effective solution for dexterous manipulation, healthcare, environmental exploration, perception of physical properties. Nonetheless, limitation many existing flexible sensors stems from their isotropic structure or material properties, preventing them simultaneously detecting both the direction magnitude applied force. Herein, high-performance 3D sensor based on orthogonal multimodal sensing, cancellation...
To evaluate the impact of coronavirus disease 2019 (COVID-19) on postoperative visual acuity, optical quality, and severity dry eye in patients after small incision lenticule extraction (SMILE). This is a retrospective, comparative study. Patients who underwent SMILE were included divided into two groups according to period at center Second Affiliated Hospital Zhejiang University. The first group before large-scale COVID-19 pandemic China (Group 1). second comprised during with confirmed...