A5115599637- Diabetes Treatment and Management
- Biochemical Analysis and Sensing Techniques
- Cancer-related molecular mechanisms research
- Spine and Intervertebral Disc Pathology
- Osteoarthritis Treatment and Mechanisms
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- Alcohol Consumption and Health Effects
- Metabolomics and Mass Spectrometry Studies
- Lung Cancer Treatments and Mutations
- Liver Disease Diagnosis and Treatment
- Folate and B Vitamins Research
- Infectious Diseases and Tuberculosis
- Medical Imaging and Analysis
- Aortic aneurysm repair treatments
- Stroke Rehabilitation and Recovery
- Acute Ischemic Stroke Management
- Bone Tissue Engineering Materials
- Musculoskeletal pain and rehabilitation
- Nutritional Studies and Diet
- Epigenetics and DNA Methylation
- Pregnancy and Medication Impact
- Cancer Genomics and Diagnostics
- Mycobacterium research and diagnosis
Gannan Medical University
2022-2025
First Hospital of Lanzhou University
2020-2025
Changsha University of Science and Technology
2025
Lanzhou University
2019-2025
Wuhan Union Hospital
2025
Huazhong University of Science and Technology
2025
Ningbo No. 2 Hospital
2024
Wenzhou Medical University
2024
Simcere Pharmaceutical (China)
2023-2024
First Affiliated Hospital of Gannan Medical University
2022-2024
Sublingual edaravone dexborneol, which can rapidly diffuse and be absorbed through the oral mucosa after sublingual exposure, is a multitarget brain cytoprotection composed of antioxidant anti-inflammatory ingredients dexborneol.
BackgroundIdentifying effective drugs to suppress vascular inflammation is a promising strategy delay the progression of abdominal aortic aneurysm (AAA). Itaconate has vital role in regulating inflammatory activation various diseases. However, itaconate AAA unknown. In this study, we explored inhibitory effect on formation and its underlying mechanisms.MethodsQuantitative PCR, western blotting immunohistochemistry were used determine Irg1 downstream Nrf2 expression human mouse samples....
Objective: The association between acylcarnitine metabolites and cardiovascular disease (CVD) in type 2 diabetes mellitus (T2DM) remains uncertain. This study aimed to investigate associations acylcarnitines CVD Chinese patients with T2DM. Methods: A cross-sectional was conducted from May 2015 August 2016. Medical records of 741 T2DM were retrieved the main electronic database Liaoning University First Affiliated Hospital. defined as having either coronary artery (CAD) or heart failure (HF)...
Objective: This study aimed to test associations between type 2 diabetes (T2DM) and metabolites in urea cycle including arginine, citrulline ornithine. Methods: used a hospital-based cross-sectional design. We retrieved medical notes of 401 in-patients with onset T2DM within two years 1522 healthy subjects who attended annual physical examination. All cases were admitted tertiary care center Jinzhou, China from May 2015 August 2016. Binary logistic regression analyses performed obtain odds...
Rationale: Most current cardiac regeneration approaches result in very limited cell division and little new cardiomyocyte (CM) mass. Positive feedback loops are vital for division, but their role CM remains unclear. We aimed to determine whether the lncRNA small nucleolar RNA host gene 1 Snhg1 (Snhg1) could form a positive loop with c-Myc induce regeneration. Methods: Quantitative PCR situ hybridization experiments were performed expression patterns fetal myocardial infarction (MI) hearts....
Abstract Osteoarthritis (OA) is a chronic degenerative disease of the bone and joints. Immune-related genes immune cell infiltration are important in OA development. We analyzed immune-related infiltrates to identify diagnostic markers. The datasets GSE51588, GSE55235, GSE55457, GSE82107, GSE114007 were downloaded from Gene Expression Omnibus database. First, R software was used differentially expressed (DEGs) (DEIRGs), functional correlation analysis conducted. Second, CIBERSORT evaluate...
Given the risks associated with autologous bone transplantation and limitations of allogeneic transplantation, scaffolds in tissue engineering that incorporate bioactive peptides are highly recommended. Teriparatide (TPTD) plays a significant role defect repair, although achieving controlled release TPTD within scaffold remains challenging. This work reports new approach for treatment teriparatide using water-in-oil-in-water (w/o/w) microspheres be equipped on gelatin (GEL)/Poly...
Abstract Purpose Spinal endoscopy is a novel minimally invasive spinal surgery technique used in recent years to treat various degenerative diseases. Metagenomic next-generation sequencing (mNGS) new method for identifying infectious microorganisms We aim evaluate the application effect of combining with mNGS diagnosing and treating infections. Methods The clinical data 62 patients suspected diseases admitted from January 2020 December 2023 were retrospectively analyzed. All underwent obtain...
ABSTRACT Wiring errors, caused by improper connections between neutral lines and protective earth (PE) due to negligence electrical technicians, are a prevalent type of fault in low‐voltage distribution systems (LVDS). These errors can cause the load current affected users flow back transformer's point via PE line as residual current, leading nuisance tripping devices (RCDs). To maintain normal power supply, may disable RCDs, which compromises safety result severe hazards such electric...
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a global health concern that necessitates early screening and timely intervention to improve prognosis. The current diagnostic protocols for MASLD involve complex procedures in specialised medical centres. This study aimed explore the feasibility of utilising machine learning models accurately screen large populations based on combination essential demographic clinical characteristics. A total 10,007 outpatients who...
Background Gamabufotalin (CS-6), a bufadienolide derived from Chansu, has been reported to exhibit anti-tumor effects in various cancers, including glioblastoma, nonsmall cell lung cancer, and breast cancer. However,its role colorectal cancer (CRC) remains unexplored. Objective Our study aimed evaluate the inhibition of CS-6 CRC cells by viability assay, colony formation comet cycle analysis firstly. And its molecular mechanism was studied immunofluorescence (IF) western blot (WB) siRNA...
Intervertebral disc (IVD) degeneration is a complex multifactorial disease model, which pathogenesis has not been fully defined. There are few studies on the information interaction between nucleus pulposus (NP) cells and cartilage endplate (CEP) cells. Exosomes, as carrier of communication cells, have become research hotspot recently. The purpose this study was to explore whether degenerative NP cells-derived exosomes promoted CEP apoptosis aggravated IVD degeneration. model induced by...
Objective Tight control of hyperglycemia reduces risk diabetic retinopathy (DR), but the residual remains high. This study aimed to explore relationships between plasma phenylalanine and tyrosine with DR in type 2 diabetes (T2D) interactions two amino acids, their secondary interaction renal dysfunction. Research design methods We extracted data 1032 patients T2D from tertiary hospital consecutively May 2015 August 2016. Binary logistic regression models restricted cubic spline were used...
Abstract Background Asparagine and aspartate homeostasis are linked with type 2 diabetes (T2D). This study aimed to explore whether asparagine metabolism interacted sex age increase the risk of T2D. Methods From 27 May 2015 3 August 2016, we consecutively retrieved 1032 T2D patients 1522 subjects without from a tertiary care hospital in Liaoning, China. Restricted cubic spline nested logistic regression was used draw odds ratio curves plasma for by age. Cut-off point selected where went...
To determine the association between plasma free fatty acid (FFA) levels and primary angle-closure glaucoma (PACG).Free in patients with PACG (n = 181) people without 340) were compared. Twenty-two FFAs six lipid classes measured using metabolomics analysis. Odds ratio (OR) of these metabolites their 95% confidence intervals (95%CI) for obtained by logistic regression. Stepwise forward selection was performed to identify that influenced risk. Areas under curve (AUC) applied assess predictive...
Bone marrow-derived mesenchymal stem cells (BMSCs) are a suitable option for cell-based tissue engineering therapies due to their ability renew and differentiate into multiple different types, such as bone. Over the last decade, effect of GNAS on regulation osteoblast differentiation has attracted great attention. Herein, this study aimed explore role in osteogenic MSCs. A total 85 GNASf/f male mice were selected animal experiments 10 BMSC isolation conduct cell experiments. The BMSCs...
Although immunotherapy has progressed in the treatment of bladder cancer, some patients still have poor prognosis. New therapeutic targets are eager to be discovered improve outcomes cancer. With development high-throughput sequencing and tumor profiling, potential biomarkers were identified. Through interpretation related data from Cancer Genome Atlas database (TCGA), key genes been drive prognosis urinary neoplasm. On account success many cancer types, we established relationship between...
Abstract Objective: This study evaluates the effectiveness of stool DNA methylation markers CNRIP1, SFRP2, and VIM, along with Fecal Occult Blood Testing (FOBT), in non-invasive screening colorectal cancer (CRC), further integrating these Light Gradient Boosting Machine (LightGBM) machine learning (ML) algorithm. Methods: The analyzed 100 samples, comprising 50 CRC patients healthy controls, from First Affiliated Hospital Gannan Medical University. Methylation Specific PCR (MSP) was used for...
In bone tissue engineering, biological scaffolds are designed with structural and functional properties that closely resemble the extracellular environment, aiming to establish a microenvironment conducive osteogenesis. Macrophages hold significant potential for promoting osteogenesis modulating behavior of tumor cells. Multiple coculture experiments macrophages osteoblasts have demonstrated macrophage polarization significantly impacts Therefore, exploring biomaterials can modulate holds...
The objective of the present study was to investigate hepatoprotective role Radix Fici Hirtae on acute alcohol-induced liver injury in mice. component extracted using petroleum ether, chloroform, ethyl acetate and n-butanol divided into three dose groups high, medium low according clinical man's normal 50 g crude drug/d (0.83 g/kg body weight). Saline concentration 10 mg/mL, 5 mg/mL 2.5 a mouse lavage (0.2 mL/10 weight) were added solution. Histopathlogical analysis performed. Finally,...
Whether vertebral augmentation can induce or aggravate the degeneration of adjacent intervertebral discs remains controversial. The purpose this study is to explore role endplate injury in disc after augmentation.The imaging data patients with single-segment osteoporotic compression fractures (OVCFs) were retrospectively analyzed. upper and lower fractured vertebrae defined as cranial caudal discs, control discs. According integrity endplates, they divided into an group a noninjury group. At...
α-Solanine, a natural small molecule compound, mainly derived from potato tubers with anti-tumor and anti-inflammatory effects. No studies have yet confirmed that α-solanine can act on tumor cells via ferroptosis, its molecular mechanism is unclear. The present study aimed to whether could induce nasopharyngeal carcinoma (NPC) cell death through ferroptosis specific mechanism. Here, was proven trigger in NPC targeting HSP90α directly. primary manifestations of α-solanine-induced HK-1 5-8F...