Zhen Shi

ORCID: 0000-0002-9715-9098
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About
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Research Areas
  • Neuroscience of respiration and sleep
  • Heart Rate Variability and Autonomic Control
  • Nitric Oxide and Endothelin Effects
  • Autophagy in Disease and Therapy
  • Renin-Angiotensin System Studies
  • Diet, Metabolism, and Disease
  • Lipid metabolism and disorders
  • Liver Disease Diagnosis and Treatment
  • Cannabis and Cannabinoid Research
  • Cancer-related molecular mechanisms research
  • Reproductive Physiology in Livestock
  • Hormonal Regulation and Hypertension
  • Mesenchymal stem cell research
  • Cardiovascular Disease and Adiposity
  • Eicosanoids and Hypertension Pharmacology
  • Regulation of Appetite and Obesity
  • Osteoarthritis Treatment and Mechanisms
  • Cardiovascular, Neuropeptides, and Oxidative Stress Research
  • Ferroptosis and cancer prognosis
  • Berberine and alkaloids research
  • Fungal Biology and Applications
  • Sesquiterpenes and Asteraceae Studies
  • Sunflower and Safflower Cultivation
  • Phonocardiography and Auscultation Techniques
  • Heme Oxygenase-1 and Carbon Monoxide

Binzhou University
2012-2024

Binzhou Medical University
2012-2024

Hubei Provincial Hospital of Traditional Chinese Medicine
2021-2022

Jilin University
2015-2021

Soochow University
2021

Wenzhou Medical University
2020

Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2020

Sichuan Agricultural University
2019

East China University of Science and Technology
2017

Stanford University
2015

Long noncoding RNAs (lncRNAs) play important roles in the development of vascular diseases.However, effect lncRNA NORAD on atherosclerosis remains unknown.This study aimed to investigate endothelial cell injury and atherosclerosis.Ox-LDL-treated human umbilical vein cells (HUVECs) high-fat-diet (HFD)-fed ApoE -/-mice were used as vitro vivo models.Results showed that NORAD-knockdown induced cycle arrest G0/G1 phase, aggravated ox-LDL-induced viability reduction, apoptosis, senescence along...

10.18632/aging.103034 article EN cc-by Aging 2020-04-08

Identifying safe and effective compounds that target to mitophagy eliminate impaired mitochondria may be an attractive therapeutic strategy for non-alcoholic fatty liver disease. Here, we investigated the effects of cyanidin-3-O-glucoside (C3G) on disease (NAFLD) underlying mechanism.Non-alcoholic was induced by a high-fat diet 16 weeks. C3G administered during last 4 In vivo, recombinant adenoviruses AAV8 were used overexpression knockdown PTEN-induced kinase 1 (PINK1), respectively. AML-12...

10.1111/bph.15083 article EN British Journal of Pharmacology 2020-04-28

The inevitable deficiency in nutrients and energy at the onset of lactation requires an optimal adaptation hepatic metabolism to overcome metabolic stress. Fatty liver is one main health disorders after parturition. Therefore, investigate changes lipid status mitochondria dairy cows with mild fatty liver, blood samples were collected from healthy (n = 15) 15). To determine effects palmitic acids (PA), major component acids, on vitro, calf hepatocytes isolated calves treated various...

10.3168/jds.2018-14546 article EN publisher-specific-oa Journal of Dairy Science 2018-08-09

Injection of leptin into white adipose tissue (WAT) increases sympathetic outflow. The present study was designed to determine the effects capsaicin and other chemicals in WAT on outflow blood pressure roles afferents hypothalamic paraventricular nucleus (PVN) afferent reflex (AAR). AAR induced by injection capsaicin, bradykinin, adenosine, adenosine triphosphate (ATP), or inguinal (iWAT) retroperitoneal (rWAT) anesthetized rats. iWAT increased renal nerve activity (RSNA) mean arterial (MAP)...

10.1152/japplphysiol.01164.2011 article EN Journal of Applied Physiology 2012-01-06

Fatty liver is a major lipid metabolic disease in perinatal dairy cows and characterized by high blood levels of non-esterified fatty acid (NEFA) insulin resistance. Berberine (BBR) has been reported to improve sensitivity mice with hepatic steatosis. Mitochondrial dysfunction considered causal factor that induces This study investigates the underlying mechanism beneficial effects BBR on mitochondrial signaling bovine hepatocytes. Revised quantitative check index (RQUICKI) was significantly...

10.3390/ijms19061691 article EN International Journal of Molecular Sciences 2018-06-06

Ageratina adenophora is an invasive plant of global importance and has a broad distribution in the Western Himalayas. Endophtytic fungus Coniochaeta sp.F-8 was found adenophora. In this paper, we aim to investigate antioxidative activity cytotoxicity metabolites from sp.F-8. Consequently, two compounds Phomoxanthone A Penialidin were isolated endophytic for first time. The structures identified by IR, NMR ESI-MS methods. Moreover, both those showed considerable vitro resulted mouse embryo...

10.1080/14786419.2019.1675060 article EN Natural Product Research 2019-10-22
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