A5032307162- Liver Disease Diagnosis and Treatment
- Lipid metabolism and disorders
- Peroxisome Proliferator-Activated Receptors
- Autophagy in Disease and Therapy
- Cancer-related molecular mechanisms research
- Lipid metabolism and biosynthesis
- Reproductive Physiology in Livestock
- Endoplasmic Reticulum Stress and Disease
- Adipose Tissue and Metabolism
- Genetic and phenotypic traits in livestock
- Diet, Metabolism, and Disease
- Diet and metabolism studies
- Ruminant Nutrition and Digestive Physiology
- Epigenetics and DNA Methylation
- Cardiac Ischemia and Reperfusion
- Metabolism, Diabetes, and Cancer
- Chromatography in Natural Products
- Drug Transport and Resistance Mechanisms
- Cannabis and Cannabinoid Research
- Cholesterol and Lipid Metabolism
- Bariatric Surgery and Outcomes
- Traditional Chinese Medicine Analysis
- Pancreatic function and diabetes
- Advanced biosensing and bioanalysis techniques
- Nitric Oxide and Endothelin Effects
Jilin University
2015-2025
First Affiliated Hospital of Jiangxi Medical College
2024-2025
Nanchang University
2024-2025
University of Macau
2025
Jilin Medical University
2024-2025
Nanjing Agricultural University
2024
Zhejiang Normal University
2024
Chinese Academy of Fishery Sciences
2024
Université Sorbonne Paris Nord
2022
Centre de Recherche Saint-Antoine
2021-2022
Previous studies have postulated the association between oxidative stress and Type 2 diabetes. Considering long pre-diabetic period with IGR (impaired glucose regulation) its high risk of developing diabetes, to test this hypothesis, we investigated pathways DNA damage in patients newly diagnosed The study population consisted 92 subjects NGT (normal tolerance), 78 113 Plasma MDA (malondialdehyde) TAC (total antioxidative capacity) status, erythrocyte GSH content SOD (superoxide dismutase)...
In liver fibrosis, myofibroblasts derive from HSCs and as yet undefined mesenchymal cells. We aimed to identify portal progenitors of myofibroblasts.Portal cells were isolated mouse bilio-vascular tree analyzed by single-cell RNA-sequencing. Thereby, we uncovered the landscape in homeostatic liver. Trajectory analysis enabled inferring a small cell population further defined surface markers used isolate it. This consisted fibroblasts with stem features (PMSCs), i.e., high clonogenicity...
Acetaminophen (APAP) overdose is the predominant cause of drug-induced liver injury worldwide. The macroautophagy/autophagy-lysosomal pathway (ALP) involved in APAP hepatotoxicity. TFEB (transcription factor EB) promotes expression genes related to autophagy and lysosomal biogenesis, thus, pharmacological activation TFEB-mediated ALP may be an effective therapeutic approach for treating APAP-induced injury. We aimed reveal effects narirutin (NR), main bioactive constituents isolated from...
Failures of radiotherapy (RT) in adaptive antitumor immunomodulation often associate with recruited tissue-repairing macrophages. Although training these macrophages to phagocytose post-RT cancer cells reverses their protumoral performance, engulfed tumor antigens are severely underrated. In fact, regulating the processing and presentation antigens, a key determinant immunogenicity, can fundamentally affect immune responses. Here it is reported that simple Alum-like adjuvant (MgAl-based...
Abstract The aim of this study was to investigate the changes in hepatic oxidative phosphorylation (OXPHOS) complexes (COs) patients and cows with non‐alcoholic steatohepatitis (NASH) mechanism that links mitochondrial dysfunction insulin resistance induced by non‐esterified fatty acids (NEFAs). Patients NASH displayed high blood NEFAs, TNF‐α IL‐6 concentrations, resistance. protein levels peroxisome proliferator‐activated receptor‐γ coactivator‐1α (PGC‐1α), mitofusin‐2 (Mfn‐2) OXPHOS...
Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis and insulin resistance there are currently no approved drugs for its treatment. Hyperactivation of mTOR complex 1 (mTORC1) subsequent impairment the transcription factor EB (TFEB)-mediated autophagy–lysosomal pathway (ALP) implicated in development NAFLD. Accordingly, agents that augment TFEB transcriptional activity may have therapeutic potential against The objective this study was to investigate effects...
Fatty liver (i.e., hepatic lipidosis) is a prevalent metabolic disorder in dairy cows during the transition period, characterized by excess accumulation of triglyceride (TG), tissue dysfunction, and cell death. Detailed pathological changes, particularly fibrosis, fatty remain to be determined. Liver fibrosis occurs as consequence damage, resulting from excessive extracellular matrix, which distorts architecture normal liver, compromising its synthetic functions. Thus, we aimed investigate...
Acetaminophen (APAP) overdose is a major cause of liver injury. Neural precursor cell expressed developmentally downregulated 4-1 (NEDD4-1) an E3 ubiquitin ligase that has been implicated in the pathogenesis numerous diseases; however, its role APAP-induced injury (AILI) unclear. Thus, this study aimed to investigate NEDD4-1 AILI. We found was dramatically response APAP treatment mouse livers and isolated hepatocytes. Hepatocyte-specific knockout exacerbated mitochondrial damage resultant...
To explore the prospective correlation between serum metals before 24 weeks' gestation and gestational diabetes mellitus (GDM) or glucose in late second trimester among southern Chinese pregnant women. A total of 8169 women were included our retrospective cohort study. Logistic regression was used to investigate relationships (Manganese [Mn], copper [Cu], lead [Pb], calcium [Ca], zinc [Zn], magnesium [Mg]) GDM. Quantile performed detect shifts associations with three time-points distribution...
Reduced feed intake during the transition period renders cows unable to meet their energy needs for maintenance and lactation, leading a state of negative balance. Severe balance initiates fat mobilization increases circulating levels free fatty acids (FFA), which could induce hepatic mitochondrial dysfunction, oxidative stress, apoptosis. Enhancing supply propionate (major gluconeogenic substrate) is feasible preventive therapeutic strategy alleviate metabolic disorders period. Whether...
The contributions of altered post-transcriptional gene silencing to the development metabolic disorders remain poorly understood thus far. objective this study was evaluate roles miR-181a in regulation hepatic glucose and lipid metabolism. MiR-181a is abundantly expressed liver, we found that blood levels were significantly increased patients dairy cows with non-alcoholic fatty liver disease, as well high-fat diet ob/ob mice. We determined sirtuin1 a target miR-181a. Moreover, peroxisome...
Background/Aims: In dairy cows, β-hydroxybutyrate (BHBA) is utilized as precursors of de novo synthesized fatty acids in mammary gland. Ketotic cows are characterized by excessive negative energy balance (NEB), which can further increase the blood BHBA concentration. Sterol regulatory element-binding protein1 (SREBP1) and cell death-inducing DNA fragmentation factor-alpha-like effector α (Cidea) play crucial roles lipid synthesis. Therefore, we hypothesized that could stimulate SREBP1/Cidea...
During the transition period in dairy cows, high circulating concentrations of nonesterified fatty acids (NEFA) increase hepatic lipid deposits and are considered a major pathological factor for liver damage. We investigated whether AdipoRon, synthetic small-molecule agonist adiponectin receptors 1 2 shown to prevent accumulation nonruminants, could alleviate NEFA-induced mitochondrial dysfunction. Bovine hepatocytes were isolated from 5 healthy Holstein female newborn calves (1 d age, 30–40...
Bile acids are cholesterol-derived molecules that primarily produced in the liver. In nonruminants with fatty liver, overproduction of bile is associated liver injury. During transition period, a metabolic disorder can affect up to 50% high-producing dairy cows. The purpose this study was provide comprehensive evaluation hepatic acid metabolism cows by assessing expression changes genes involved synthesis, export, and uptake. serum activities aspartate aminotransferase, alanine glutamate...
Angiotensin converting enzyme (ACE) inhibitory peptides are biologically active that play a very important role in blood pressure regulation. In previous experiments, we obtained an ACE peptide Val-Leu-Pro-Val-Pro (VLPVP) by DNA recombinant technology. The purpose of this study was to examine the bidirectional transport VLPVP using human intestinal Caco-2 monolayers. permeability coefficient ( P app) values over 4-8 mmol/L ranged from 7.44 x 10(-8) 1.35 10(-6) cm/s for apical (AP)...
Insulin resistance is often characterized as the most critical factor contributing to development of (T2D) type 2 diabetes. MicroRNAs (miRNAs) are endogenous non‐coding short single‐stranded RNAs that function negative regulators in many physiological and pathological processes. The objective this study was evaluate roles miR‐125b regulation insulin sensitivity hepatocytes. We found hepatic levels were significantly increased patients with diabetes, high fat diet (HFD) mice, ob/ob db/db...
When ketosis occurs, supraphysiological levels of free fatty acids (FFA) can cause oxidative injury to the mammary gland and autophagy regulate cellular status. The aim this study was investigate status tissue its associations with stress in healthy clinically ketotic dairy cows. Mammary blood samples were collected from cows [n = 15, β-hydroxybutyrate (BHB) <0.6 mM] (n BHB >3.0 mM) at 3 15 (average 7) days milk. For vitro study, bovine epithelial cells (BMEC) isolated treated 0, 0.3, 0.6,...
Mitochondria are the main site of fatty acid oxidation and reactive oxygen species (ROS) formation. Damaged or dysfunctional mitochondria induce oxidative stress increase risk lipid accumulation. During process mitophagy, PTEN induced kinase 1 (PINK1) accumulates on damaged recruits cytoplasmic Parkin to mitochondria. As an autophagy receptor protein, sequestosome-1 (p62) binds Parkin-ubiquitinated outer mitochondrial membrane proteins microtubule-associated protein light chain 3 (LC3)...
BACKGROUND The efficacy of various bariatric surgeries varies in reducing blood glucose levels. Given the distinct mechanisms and anatomical alterations associated with each procedure, it is crucial to compare their glycemic control outcomes. We hypothesize that proximal small intestinal bypass (PSIB) superior reduction over Roux-en-Y gastric (RYGB) jejunoileal (JIB). AIM To effectiveness PSIB, RYGB, JIB lowering glucose. METHODS Rats streptozotocin-induced diabetes were randomly divided...
Fatty liver is a major metabolic disorder in perinatal dairy cows, characterized by elevated plasma concentrations of nonesterified fatty acids (NEFA) and hepatic inflammation. Glutathione S-transferase mu 2 (GSTM2), phase II detoxification enzyme, regulates cellular antioxidant processes nonruminants. However, its involvement NEFA-induced inflammation cows with remains unclear. This study aimed to elucidate the role GSTM2 mediating caused NEFA levels severe liver. An vivo was conducted...