A5109835411- Genetic Mapping and Diversity in Plants and Animals
- Cancer-related molecular mechanisms research
- Hearing, Cochlea, Tinnitus, Genetics
- Plant Gene Expression Analysis
- Congenital heart defects research
- Retinal Development and Disorders
- Genomics and Phylogenetic Studies
- Genetics and Plant Breeding
- Plant biochemistry and biosynthesis
- Zebrafish Biomedical Research Applications
- Neurogenesis and neuroplasticity mechanisms
- Transplantation: Methods and Outcomes
- Plant Molecular Biology Research
- Plant nutrient uptake and metabolism
- Genetic and phenotypic traits in livestock
- Wheat and Barley Genetics and Pathology
- Genetic diversity and population structure
- Gut microbiota and health
- Metabolomics and Mass Spectrometry Studies
- Antibiotic Resistance in Bacteria
- Developmental Biology and Gene Regulation
- Computational Drug Discovery Methods
- RNA modifications and cancer
- Photosynthetic Processes and Mechanisms
- Lipid metabolism and biosynthesis
University of Chinese Academy of Sciences
2025
Shenyang Institute of Automation
2025
University of Macau
2021-2025
Northwest A&F University
2025
Army Medical University
2024
Hunan Agricultural University
2019-2024
Huazhong Agricultural University
2015-2023
Kunming Medical University
2022
Jiaxing University
2020-2021
First Hospital of Jiaxing
2020-2021
LIM-homeodomain (HD) and POU-HD transcription factors play crucial roles in neurogenesis. However, it remains largely unknown how they cooperate this process what downstream target genes regulate. Here, we show that ISL1, a LIM-HD protein, is co-expressed with BRN3B, factor, nascent post-mitotic retinal ganglion cells (RGCs). Similar to the Brn3b-null retinas, retina-specific deletion of Isl1 results apoptosis majority RGCs RGC axon guidance defects. The Brn3b double null mice display more...
Whereas the mammalian retina possesses a repertoire of factors known to establish general retinal cell types, these alone cannot explain vast diversity neuronal subtypes. In other CNS regions, differentiation diverse pools is governed by coordinately acting LIM-homeodomain proteins including Islet-class factor Islet-1 (Isl1). We report that deletion Isl1 profoundly disrupts function as assessed electroretinograms and vision optomotor behavior. These deficits are coupled with marked...
Summary Improvement of grain yield is an essential long‐term goal maize ( Zea mays ) breeding to meet continual and increasing food demands worldwide, but the genetic basis remains unclear. We used 10 different recombination inbred line RIL populations genotyped with high‐density markers phenotyped in multiple environments dissect architecture ear traits. Three methods were map quantitative trait loci QTL s) affecting found 17–34 minor‐ or moderate‐effect that influence traits, little...
Atoh1 encodes a basic helix-loop-helix (bHLH) transcription factor required for the development of inner ear sensory epithelia, dorsal spinal cord, brainstem, cerebellum, and intestinal secretory cells. In this study, to create genetic tool research on gene function in organs, we generated an Atoh1-Cre knock-in mouse line by replacing entire coding sequences with Cre sequences. Atoh1(Cre/+) mice were viable, fertile, displayed no visible defects whereas Atoh1(Cre/Cre) died perinatally. The...
Maize was domesticated from lowland teosinte (Zea mays ssp. parviglumis), but the contribution of highland mexicana, hereafter mexicana) to modern maize is not clear. Here, two genomes for Mo17 (a inbred) and mexicana are assembled using a meta-assembly strategy after sequencing 10 lines derived maize-teosinte cross. Comparative analyses reveal high level diversity between Mo17, B73, including three Mb-size structural rearrangements. The spontaneous mutation rate estimated be 2.17 × 10-8...
Maize (Zea mays) is a major staple crop. kernel size and weight are important contributors to its yield. Here, we measured length, width, thickness, hundred weight, test in 10 recombinant inbred line populations dissected their genetic architecture using three statistical models. In total, 729 quantitative trait loci (QTLs) were identified, many of which identified all models, including 22 QTLs that each can explain more than 10% phenotypic variation. To provide candidate genes for these...
Graphical Abstract Overall BacAnt’s service workflow. The figure is adapted with permissions from IntegronFinder ( Cury et al., 2016 ).
Failures of radiotherapy (RT) in adaptive antitumor immunomodulation often associate with recruited tissue-repairing macrophages. Although training these macrophages to phagocytose post-RT cancer cells reverses their protumoral performance, engulfed tumor antigens are severely underrated. In fact, regulating the processing and presentation antigens, a key determinant immunogenicity, can fundamentally affect immune responses. Here it is reported that simple Alum-like adjuvant (MgAl-based...
Abstract The mammalian retina is comprised of six major neuronal cell types and subdivided into more morphological physiological subtypes. transcriptional machinery underlying these subtype fate choices largely unknown. LIM‐homeodomain protein, Isl1, plays an essential role in central nervous system (CNS) differentiation but its relationship to retinal neurogenesis remains We report here dynamic spatiotemporal expression the mouse retina. Among bipolar interneurons, Isl1 commences at...
Amino acids are both constituents of proteins, providing the essential nutrition for humans and animals, signalling molecules regulating growth development plants. Most cultivars maize deficient in amino such as lysine tryptophan. Here, we measured levels 17 different total acids, created 48 derived traits mature kernels from a diversity inbred collection three recombinant line (RIL) populations. By GWAS, 247 281 significant loci were identified two environments, 5.1 4.4 each trait,...
HDR syndrome (also known as Barakat syndrome) is a developmental disorder characterized by hypoparathyroidism, sensorineural deafness and renal disease. Although genetic mapping subsequent functional studies indicate that GATA3 haplo-insufficiency causes human syndrome, the role of Gata3 in auditory system development largely unknown. In this study, we show continuously expressed developing mouse inner ear. Conditional knockout ear disrupts morphogenesis ear, resulting disorganized shortened...
SUMMARY Metabolites are the intermediate and final products of metabolism, which play essential roles in plant growth, evolution adaptation to changing climates. However, it is unclear how contributes metabolic variation plants. Here, we investigated metabolomics data from leaf seed tissues maize rice. Using principal components analysis based on metabolites but not metabolites, could be clearly separated for rice Indica Japonica accessions, while two subgroups, temperate tropical, showed...
Gfi1 encodes a zinc-finger transcription factor essential for the development and maintenance of haematopoiesis inner ear. In mouse ear, expression is confined to hair cells during in adulthood. To construct genetic tool ear cell-specific gene deletion, we generated Gfi1-Cre line by knocking-in Cre coding sequences into locus inactivating endogenous Gfi1. The specificity efficiency recombinase-mediated recombination developing was revealed through conditional R26R-lacZ reporter gene. onset...
Flowering time is a trait vital to the adaptation of flowering plants different environments. Here, we report that CCT domain genes play an important role in maize (Zea mays L.). Among 53 family identified maize, 28 were located quantitative locus regions and 15 significantly associated with time, based on candidate-gene association mapping analysis. Furthermore, gene named ZmCOL3 was shown be repressor flowering. Overexpressing delayed by approximately 4 d, either long-day or short-day...
Flavonoids constitute a diverse class of secondary metabolites which exhibit potent bioactivities for human health and have been indicated to play an important role in plant development defense. However, accumulation variation flavonoid content maize lines the genes responsible their biosynthesis this crop remain largely unknown. In study, we combine genetic mapping, metabolite profiling gene regulatory network analysis further enhance understanding pathway. We repeatedly detected 25 QTL...
Abstract Genome information from model species such as rice can assist in the cloning of genes a complex genome, maize. Here, we identified maize ortholog GS5 that contributes to kernel development The genome‐wide association analysis expression levels ZmGS5 , and 15 its 26 paralogs, trans ‐regulator on chromosome 7, which was BAK1 ‐like gene. This gene named ZmBAK1‐7 could regulate three paralogs. Candidate‐gene analyses revealed these five were associated with development‐related traits....
One of the most significant evolutionary changes underlying highly developed cognitive abilities humans is greatly enlarged brain volume. In addition to being far greater than in other species, volume human exhibits extensive variation and distinct sexual dimorphism general population. However, little known about genetic mechanisms normal as well observed sex difference Here we show that interleukin-3 (IL3) strongly associated with four genetically divergent populations. We identified a...
Phytol is one of the key precursors for tocopherol synthesis in plants, however, underlying mechanisms concerning accumulation remain poorly understood. In this study, qVE5, a major QTL affecting maize kernels was identified via positional cloning approach. qVE5 encodes protochlorophyllide oxidoreductase (ZmPORB2), which localizes to chloroplast. Overexpression ZmPORB2 increased content both leaves and kernels. Candidate gene association analysis 5/8-bp insertion/deletion (InDel058) 5'...