A5076739463- Autophagy in Disease and Therapy
- Liver Disease Diagnosis and Treatment
- Lipid metabolism and biosynthesis
- Reproductive Physiology in Livestock
- Cancer-related molecular mechanisms research
- Lipid metabolism and disorders
- Peroxisome Proliferator-Activated Receptors
- Diet, Metabolism, and Disease
- Genetic and phenotypic traits in livestock
- Endoplasmic Reticulum Stress and Disease
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Adipose Tissue and Metabolism
- Nitric Oxide and Endothelin Effects
- Receptor Mechanisms and Signaling
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- Redox biology and oxidative stress
- Circadian rhythm and melatonin
- Advanced biosensing and bioanalysis techniques
- Ruminant Nutrition and Digestive Physiology
- Plant Molecular Biology Research
- RNA modifications and cancer
- Plant Stress Responses and Tolerance
- Plant nutrient uptake and metabolism
Jilin University
2015-2025
Xi'an Medical University
2021-2025
Jilin Medical University
2024-2025
Zhengzhou Central Hospital
2025
Second Affiliated Hospital of Soochow University
2023-2024
Yulin University
2024
Zhengzhou University
2022-2024
Tibet University
2024
Soochow University
2023-2024
Institute of Microbiology
2023
Antibiotic resistance genes (ARGs) have accelerated microbial threats to human health in the last decade. Many can confer resistance, but evaluating relative risks of ARGs is complex. Factors such as abundance, propensity for lateral transmission and ability be expressed pathogens are all important. Here, an analysis at metagenomic level from various habitats (6 types habitats, 4572 samples) detects 2561 that collectively conferred 24 classes antibiotics. We quantitatively evaluate risk...
Abstract Under phosphate (P i ) starvation, plants increase the secretion of purple acid phosphatases (PAPs) into rhizosphere to scavenge organic phosphorus (P) for plant use. To date, only a few members PAP family have been characterized in crops. In this study, we identified novel secreted rice, OsPAP10c , and investigated its role utilization external P. belongs monocotyledon‐specific subclass Ia group PAPs is specifically expressed epidermis/exodermis cell layers roots. Both transcript...
Abstract Background Circular RNAs (circRNAs) are involved in diverse processes that drive cancer development. However, the expression landscape and mechanistic function of circRNAs osteosarcoma (OS) remain to be studied. Methods Bioinformatic analysis high-throughput RNA sequencing tools were employed identify differentially expressed between OS adjacent noncancerous tissues. The level circ_001422 clinical specimens cell lines was measured using qRT-PCR. association with clinicopathologic...
Acetaminophen (APAP) overdose is the predominant cause of drug-induced liver injury worldwide. The macroautophagy/autophagy-lysosomal pathway (ALP) involved in APAP hepatotoxicity. TFEB (transcription factor EB) promotes expression genes related to autophagy and lysosomal biogenesis, thus, pharmacological activation TFEB-mediated ALP may be an effective therapeutic approach for treating APAP-induced injury. We aimed reveal effects narirutin (NR), main bioactive constituents isolated from...
Abstract The aim of this study was to investigate the changes in hepatic oxidative phosphorylation (OXPHOS) complexes (COs) patients and cows with non‐alcoholic steatohepatitis (NASH) mechanism that links mitochondrial dysfunction insulin resistance induced by non‐esterified fatty acids (NEFAs). Patients NASH displayed high blood NEFAs, TNF‐α IL‐6 concentrations, resistance. protein levels peroxisome proliferator‐activated receptor‐γ coactivator‐1α (PGC‐1α), mitofusin‐2 (Mfn‐2) OXPHOS...
Aerobic glycolysis is essential for tumor growth and survival. Activation of multiple carcinogenic signals contributes to metabolism reprogramming during malignant transformation cancer. Recently nitric oxide has been noted promote but the mechanism remains elusive. We report here dual role in glycolysis: low/physiological (≤ 100 nM) promotes ATP production, oxidative defense cell proliferation ovary cancer cells, whereas excess (≥ 500 inhibits it. Nitric a positive effect on by inducing...
Aluminum (Al) toxicity is a major yield-limiting factor for crops in acidic soils. In this work, we have investigated the potential role of spermidine (Spd) on Al rice chloroplasts. Exogenous Spd markedly reduced concentration and elevated other nutrient elements such as Mn, Mg, Fe, K, Ca, Mo chloroplasts Al-treated plants. Meanwhile, further activated arginine decarboxylase (ADC) activity key enzyme polyamine (PA) synthesis, enhanced PA contents application dramatically addressed Al-induced...
Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis and insulin resistance there are currently no approved drugs for its treatment. Hyperactivation of mTOR complex 1 (mTORC1) subsequent impairment the transcription factor EB (TFEB)-mediated autophagy–lysosomal pathway (ALP) implicated in development NAFLD. Accordingly, agents that augment TFEB transcriptional activity may have therapeutic potential against The objective this study was to investigate effects...
During phosphate (Pi) starvation or leaf senescence, the accumulation of intracellular and extracellular purple acid phosphatases (PAPs) increases in plants order to scavenge organic phosphorus (P). In this study, we demonstrated that a PAP-encoding gene rice, OsPAP26, is constitutively expressed all tissues. While abundance OsPAP26 transcript not affected by Pi supply, it up-regulated during senescence. Furthermore, deprivation senescence greatly increased protein. Overexpression RNA...
Iron is an indispensable micronutrient for plant growth and development. Limited bioavailability of Fe in the soil leads to iron deficiency chlorosis plants yield loss. In this study, two soybean basic helix-loop-helix transcription factors, GmbHLH57 GmbHLH300, were identified response Fe-deficiency. Both factors are expressed roots nodules, induced by deficiency; these patterns confirmed transgenic hairy expressing constructs endogenous promoters fused a GUS reporter gene. Bimolecular...
The dysfunction of type I interferon (IFN) signaling is an important mechanism immune escape and metastasis in tumors. Increased NOS1 expression has been detected melanoma, which correlated with dysfunctional IFN poor response to immunotherapy, but the specific not determined. In this study, we investigated regulation on clarified relevant molecular mechanisms.After stable transfection A375 cells plasmids, transcription IFNα-stimulated genes (ISGs) were assessed using pISRE luciferase...
In Alzheimer's disease (AD), cerebral iron accumulation colocalizes with the pathological proteins amyloid-β (Aβ) and tau. Furthermore, tau-induced cortical thinning is associated cognitive decline. this study, quantitative susceptibility mapping (QSM) was used to investigate whole-brain distribution pattern of deposition its relationships cognition thickness in AD.This cross-sectional study prospectively recruited 30 participants AD 26 age- sex-matched healthy controls (HCs). All underwent...
Acetaminophen (APAP) overdose is a major cause of liver injury. Neural precursor cell expressed developmentally downregulated 4-1 (NEDD4-1) an E3 ubiquitin ligase that has been implicated in the pathogenesis numerous diseases; however, its role APAP-induced injury (AILI) unclear. Thus, this study aimed to investigate NEDD4-1 AILI. We found was dramatically response APAP treatment mouse livers and isolated hepatocytes. Hepatocyte-specific knockout exacerbated mitochondrial damage resultant...
Abstract Autophagy is a cellular survival mechanism that involves the catabolic degradation of damaged proteins and organelles during periods metabolic stress, when overly stimulated, commonly contributes to cell death. Nitric oxide (NO), potent messenger, participates in complex which assists controlling autophagy. However, by endogenous NO formed distinct isoforms nitric synthase (NOS) helps regulate autophagy cancer cells remains unclear. Here we report NOS1 reduces excessive levels...
Abstract G protein‐coupled receptors (GPCRs) transmit extracellular signals into cells by activating protein‐ and β‐arrestin‐dependent pathways. Extracellular signal‐regulated kinases (ERKs) play a central role in integrating these different linear inputs coming from variety of GPCRs to regulate cellular functions. Here, we investigated human melatonin MT 1 2 signaling through the ERK1/2 cascade employing biochemical techniques together with pharmacological inhibitors siRNA molecules. We...
One of the malignant transformation hallmarks is metabolism reprogramming, which plays a critical role in biosynthetic needs unchecked proliferation, abrogating cell death programs, and immunologic escape. However, mechanism metabolic switch not fully understood. Here, we found that S-nitrosoproteomic profile endogenous nitrogen oxide ovarian cancer cells targeted multiple components processes. Phosphofructokinase (PFKM), one most important regulatory enzymes glycolysis, was S-nitrosylated...
Reduced feed intake during the transition period renders cows unable to meet their energy needs for maintenance and lactation, leading a state of negative balance. Severe balance initiates fat mobilization increases circulating levels free fatty acids (FFA), which could induce hepatic mitochondrial dysfunction, oxidative stress, apoptosis. Enhancing supply propionate (major gluconeogenic substrate) is feasible preventive therapeutic strategy alleviate metabolic disorders period. Whether...
The contributions of altered post-transcriptional gene silencing to the development metabolic disorders remain poorly understood thus far. objective this study was evaluate roles miR-181a in regulation hepatic glucose and lipid metabolism. MiR-181a is abundantly expressed liver, we found that blood levels were significantly increased patients dairy cows with non-alcoholic fatty liver disease, as well high-fat diet ob/ob mice. We determined sirtuin1 a target miR-181a. Moreover, peroxisome...
Background/Aims: In dairy cows, β-hydroxybutyrate (BHBA) is utilized as precursors of de novo synthesized fatty acids in mammary gland. Ketotic cows are characterized by excessive negative energy balance (NEB), which can further increase the blood BHBA concentration. Sterol regulatory element-binding protein1 (SREBP1) and cell death-inducing DNA fragmentation factor-alpha-like effector α (Cidea) play crucial roles lipid synthesis. Therefore, we hypothesized that could stimulate SREBP1/Cidea...
During the transition period in dairy cows, high circulating concentrations of nonesterified fatty acids (NEFA) increase hepatic lipid deposits and are considered a major pathological factor for liver damage. We investigated whether AdipoRon, synthetic small-molecule agonist adiponectin receptors 1 2 shown to prevent accumulation nonruminants, could alleviate NEFA-induced mitochondrial dysfunction. Bovine hepatocytes were isolated from 5 healthy Holstein female newborn calves (1 d age, 30–40...
Bile acids are cholesterol-derived molecules that primarily produced in the liver. In nonruminants with fatty liver, overproduction of bile is associated liver injury. During transition period, a metabolic disorder can affect up to 50% high-producing dairy cows. The purpose this study was provide comprehensive evaluation hepatic acid metabolism cows by assessing expression changes genes involved synthesis, export, and uptake. serum activities aspartate aminotransferase, alanine glutamate...
<title>Abstract</title> <bold>Objective: </bold>This study aimed to investigate the association between Body Roundness Index (BRI) and risk of sarcopenia in older adults. <bold>Methods:</bold> A total 2,798 individuals aged 60 years without at baseline were drawn from China Health Retirement Longitudinal Study (CHARLS). We investigated relationship BRI using logistic regression analysis. Subgroup analysis was conducted explore across different groups. Additionally, restricted cubic spline...