A5049780967- Plant Stress Responses and Tolerance
- Plant nutrient uptake and metabolism
- Wheat and Barley Genetics and Pathology
- Bone Tissue Engineering Materials
- Genetic Mapping and Diversity in Plants and Animals
- Plant Molecular Biology Research
- Plant responses to water stress
- Tissue Engineering and Regenerative Medicine
- Light effects on plants
- Food composition and properties
- Plant-Microbe Interactions and Immunity
- Bone Metabolism and Diseases
- Photosynthetic Processes and Mechanisms
- Orthopaedic implants and arthroplasty
- Bone health and treatments
- Genetics and Plant Breeding
- Aluminum toxicity and tolerance in plants and animals
- Electrospun Nanofibers in Biomedical Applications
- Extracellular vesicles in disease
- Bone health and osteoporosis research
- Advanced Neural Network Applications
- Adversarial Robustness in Machine Learning
- Seed Germination and Physiology
- Clay minerals and soil interactions
- Bone and Joint Diseases
Henan Agricultural University
2025
First Affiliated Hospital Zhejiang University
2022-2025
Qingdao University
2025
University of Tasmania
2020-2024
Zhejiang University
2014-2024
Western Sydney University
2015-2024
Nanjing Drum Tower Hospital
2024
Nanjing University of Chinese Medicine
2024
Institute of Geology and Geophysics
2024
Chinese Academy of Sciences
2024
Chloroplast retrograde signaling networks are vital for chloroplast biogenesis, operation, and signaling, including excess light drought stress signaling. To date, has been considered in the context of land plant adaptation, but not regarding origin evolution cascades linking function to stomatal regulation. We show that key elements process, nucleotide phosphatase (SAL1) 3'-phosphoadenosine-5'-phosphate (PAP) metabolism, evolved streptophyte algae-the algal ancestors plants. discover an...
The pore architecture of porous scaffolds is a critical factor in osteogenesis, but it challenge to precisely configure strut-based because the inevitable filament corner and geometry deformation. This study provides tailoring strategy which series Mg-doped wollastonite with fully interconnected networks curved architectures called triply periodic minimal surfaces (TPMS), are similar cancellous bone, fabricated by digital light processing technique. sheet-TPMS geometries (s-Diamond,...
Cutaneous trauma repair is still a challenge in the clinic due to scar formation and slow healing rate, especially for diabetic patients. Various drug-loading wound dressings have been explored solve this problem. Mesenchymal stem cell (MSC)-derived exosomes considered as potential cell-free drug because of their anti-inflammation function tissue property that are comparable MSCs. Herein, composite dressing (Exo/Gel) consisting chitosan hydrogel adipose MSC-derived exosome (ADMSC–Exo) was...
Organelle-nuclear retrograde signaling regulates gene expression, but its roles in specialized cells and integration with hormonal remain enigmatic. Here we show that the SAL1-PAP (3′-phosphoadenosine 5′- phosphate) pathway interacts abscisic acid (ABA) to regulate stomatal closure seed germination Arabidopsis. Genetically or exogenously manipulating PAP bypasses canonical components ABA Insensitive 1 (ABI1) Open Stomata (OST1); priming an alternative restores ABA-responsive ROS bursts, ion...
Maintaining potassium (K(+) ) nutrition and a robust guard cell K(+) inward channel activity is considered critical for plants' adaptation to fluctuating challenging growth environment. ABA induces stomatal closure through hydrogen peroxide nitric oxide (NO) along with subsequent ion channel-mediated loss of anions. However, the interactions NO synthesis signalling activities have not been fully explored in Arabidopsis. Physiological molecular techniques were employed dissect interaction...
Inflammatory responses of nucleus pulposus (NP) can induce imbalanced anabolism and catabolism extracellular matrix, the cytosolic dsDNA accumulation STING-NF-κB pathway activation found in NP inflammation are considered as fairly important cause intervertebral disc (IVD) degeneration. Herein, we constructed a siSTING delivery hydrogel aldehyde hyaluronic acid (HA-CHO) poly(amidoamine) PAMAM/siRNA complex to intervene abnormal STING signal for IVD degeneration treatment, where formation...
Myopia is a leading cause of visual impairment and blindness worldwide. However, safe accessible approach for myopia control prevention currently unavailable. Here, we investigated the therapeutic effect dietary supplements omega-3 polyunsaturated fatty acids (ω-3 PUFAs) on progression in animal models decreases choroidal blood perfusion (ChBP) caused by near work, risk factor young adults. We demonstrated that daily gavage ω-3 PUFAs (300 mg docosahexaenoic acid [DHA] plus 60...
A critical-sized bone defect, which cannot be repaired through self-healing, is a major challenge in clinical therapeutics. The combination of biomimetic hydrogels and nano-hydroxyapatite (nano-HAP) promising way to solve this problem by constructing an osteogenic microenvironment. However, it challenging generate nano-HAP with similar morphology structure that natural bone, limits the improvement regeneration hydrogels. Inspired our previous works on organic-inorganic cocross-linking, here,...
The pore morphology design of bioceramic scaffolds plays a substantial role in the induction bone regeneration. Specifically, effects different scaffold geometry designs on angiogenesis and new regeneration remain unclear. Therefore, we fabricated Mg/Sr co-doped wollastonite (MS-CSi) with three geometries (gyroid, cylindrical, cubic) compared their osteogenesis vitro vivo. MS-CSi were by digital light processing (DLP) printing technology. structure, mechanical properties, degradation rate...
Stomatal operation is crucial for optimising plant water and gas exchange represents a major trait conferring abiotic stress tolerance in plants. About 56% of agricultural land around the globe classified as acidic, Al toxicity limiting factor affecting performance such soils. While most research work field discusses impact stresses drought or salinity on stomatal operation, toxic metals and, specifically aluminium (Al) receives much less attention. We aim to fill this knowledge gap by...
Treatment of osteoarthritis (OA) remains challenging owing to its complex pathological microenvironment, which involves reactive oxygen species, chronic inflammation, mitochondrial dysfunction, energy deficiency, and cartilage degeneration. Herein, we report for extracellular vesicles (SP-EVs) derived from the photosynthetic microorganism Spirulina platensis contain antioxidative ATP-dependent active metabolic-related compounds OA treatment. SP-EVs were effectively delivered chondrocytes,...
Objective: Resveratrol has been confirmed to improve bone quality and delay osteoporosis, but the mechanisms have not thoroughly elucidated. In this report, we investigated osteogenic differentiation effect of resveratrol on senescent mesenchymal stem cells (BMSCs) involvement AMP-activated protein kinase (AMPK)/ reactive oxygen species (ROS) signaling pathway.Methods: Cell senescence, viability, BMSCs influenced by were ROS production AMPK expression detected.Results: characterized...
Abstract Scar formation seriously affects the repair of damaged skin especially in adults and excessive inflammation has been considered as reason. The self-assembled peptide-hydrogels are ideal biomaterials for wound healing due to their similar nanostructure natural extracellular matrix, hydration environment serving drug delivery systems. In our study, resveratrol, a polyphenol compound with anti-inflammatory effect, is loaded into peptide-hydrogel (Fmoc-FFGGRGD) form dressing (Pep/RES)....
Silicon (Si) has been widely reported to improve plant resistance water stress via various mechanisms including cuticular Si deposition reduce leaf transpiration. However, there is limited understanding of the effects on stomatal physiology, underlying and implications for stress. We grew tall fescue (Festuca arundinacea Schreb. cv. Fortuna) hydroponically, with or without Si, treated half plants 20% polyethylene glycol impose physiological drought (osmotic stress). Scanning electron...
Summary Heat stress is a major environmental threat affecting crop growth and productivity. However, the molecular mechanisms associated with plant responses to heat are poorly understood. Here, we identified stress‐sensitive mutant, hts1 , in rice. HTS1 encodes thylakoid membrane‐localized β‐ketoacyl carrier protein reductase (KAR) involved de novo fatty acid biosynthesis. Phylogenetic bioinformatic analysis showed that probably originated from streptophyte algae evolutionarily conserved...
Abstract Cell‐mediated mineralization is essential for bone formation and regeneration. In this study, it proven that extracellular matrix (ECM) of decellularized periosteum can play an initiative independent role in bone‐like apatite formation. Using scaffold, revealed ECM scaffold itself promote critical defect regeneration nude mouse ectopic ossification. The natural collagen serve as a 3D structural template Ca–P nuclei initiation, controlling the size orientation mineral crystals....
Ferns appear in the fossil record some 200 Myr before angiosperms. However, as angiosperm-dominated forest canopies emerged Cretaceous period there was an explosive diversification of modern (leptosporangiate) ferns, which thrived low, blue-enhanced light beneath angiosperm canopies. A mechanistic explanation for this transformative event ferns has remained elusive. We used physiological assays, transcriptome analysis and evolutionary bioinformatics to investigate a potential connection...
Crop height not only determines plant resistance to lodging and crowding, but also affects crop architecture, apical dominance, biomass, mechanical harvesting. Plant is determined by the internode elongation, regulated genes involved in gibberellin (GA) brassinosteroid (BR) biosynthesis or related signaling networks. Plants’ genetic inability synthesize respond GAs BRs induce dwarfness. However, mechanisms of for controlling individually collectively are still unclear. Since stem...
Acetaminophen (APAP) overdose is a major cause of liver injury. Neural precursor cell expressed developmentally downregulated 4-1 (NEDD4-1) an E3 ubiquitin ligase that has been implicated in the pathogenesis numerous diseases; however, its role APAP-induced injury (AILI) unclear. Thus, this study aimed to investigate NEDD4-1 AILI. We found was dramatically response APAP treatment mouse livers and isolated hepatocytes. Hepatocyte-specific knockout exacerbated mitochondrial damage resultant...
Nitrate reductases NIA1 and NIA2 determine NO production in plants are critical to abscisic acid (ABA)-induced stomatal closure. However, the role for ABA signaling has not been paid much attention nitrate reductase loss-of-function mutant nia1nia2. Recently, we have demonstrated that ABA-inhibited K+in current ABA-enhanced slow anion were absent Exogenous restored regulation of these channels closure In this study, found mutating impaired nearly all key components guard cell pathway...