A5100360548- Nuts composition and effects
- Myasthenia Gravis and Thymoma
- Plant and Fungal Interactions Research
- Peripheral Neuropathies and Disorders
- Renal cell carcinoma treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Parkinson's Disease and Spinal Disorders
- Liver Disease Diagnosis and Treatment
- Lung Cancer Research Studies
- Head and Neck Cancer Studies
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Radiomics and Machine Learning in Medical Imaging
- Spine and Intervertebral Disc Pathology
- Ultrasound Imaging and Elastography
- interferon and immune responses
- Brain Metastases and Treatment
- Ferroptosis and cancer prognosis
- Musculoskeletal pain and rehabilitation
- Genomics and Chromatin Dynamics
- Cardiac, Anesthesia and Surgical Outcomes
- Nutrition and Health in Aging
- Lung Cancer Treatments and Mutations
- Pituitary Gland Disorders and Treatments
- Ultrasound and Hyperthermia Applications
First Affiliated Hospital of Kunming Medical University
2023-2025
Kunming Medical University
2023-2025
Sun Yat-sen University
2017-2025
Ningde Normal University
2023-2025
The First Affiliated Hospital, Sun Yat-sen University
2017-2025
Second Military Medical University
2019-2025
Shanghai Changzheng Hospital
2024-2025
Xiamen University
2020-2025
Hangzhou Medical College
2025
Zhejiang Provincial People's Hospital
2025
In this study we report on the clinical and autoimmune characteristics of severe critical novel coronavirus pneumonia caused by acute respiratory syndrome‒associated 2 (SARS‐CoV‐2). The clinical, autoimmune, laboratory 21 patients who had laboratory‐confirmed cases disease 2019 (COVID‐19) from intensive care unit Huangshi Central Hospital, Hubei Province, China, were investigated. A total (13 men 8 women), including (38.1%) 13 (61.9%) cases, enrolled. Cough (90.5%) fever (81.0%) dominant...
ABSTRACT Background Recurrence is common in chronic low back pain (CLBP). However, predicting the recurrence risk remains a challenge. The aim to develop and validate machine learning tool predict patients with CLBP by using multidimensional medical information. Methods This prospective cohort study consecutively enrolled 341 from two hospitals between 1 January 2021 31 December 2021. Patients both centres were used for model development internal validation, employing multivariate logistic...
Abstract Transcription factors (TFs) and their target genes have important functions in human diseases biological processes. Gene expression profile analysis before after knockdown or knockout is one of the most strategies for obtaining TFs exploring TF functions. Human gene datasets with are accumulating rapidly. Based on urgent need to comprehensively effectively collect process these data, we developed KnockTF (http://www.licpathway.net/KnockTF/index.html), a comprehensive database...
Inflammatory responses of nucleus pulposus (NP) can induce imbalanced anabolism and catabolism extracellular matrix, the cytosolic dsDNA accumulation STING-NF-κB pathway activation found in NP inflammation are considered as fairly important cause intervertebral disc (IVD) degeneration. Herein, we constructed a siSTING delivery hydrogel aldehyde hyaluronic acid (HA-CHO) poly(amidoamine) PAMAM/siRNA complex to intervene abnormal STING signal for IVD degeneration treatment, where formation...
In the context of global warming, frequency heat wave and concentration fine particulate matter (PM2.5) have increased, more people are co-exposed to air pollution extreme heat. However, interaction between PM2.5 on cardiovascular disease (CVD) mortality remained largely unknown. We conducted a time-stratified case-crossover study 40,169 CVD deaths in Shenzhen, China 2013 2022. Meteorological data pollutants information were obtained based residential addresses from validated grid datasets....
The common walnut Juglans regia and its related species in the genus are important economic trees, which have been widely grown for nut wood productions many counties. In genus, there ~ 21 diploid all with 2n = 32 chromosomes, can be divided into four major sections based on phylogenetic analyses fruit morphology – Cardiocaryon (e.g. J. cathayensis mandshurica), sigillata most popular one regia), Trachycaryon cinerea) Rhysocaryon hindsii, nigra microcarpa) (Aradhya et al., 2007). For...
Abstract Background Common walnut ( Juglans regia L.) is one of the top four most consumed nuts in world due to its health benefits and pleasant taste. Despite economic importance, evolutionary history genetic control adaptation agronomic traits remain largely unexplored. Results We report a comprehensive genomic variation map based on whole-genome resequencing 815 accessions. Evolutionary analyses suggest that Chinese J. diverged from sigillata with extensive hybridizations after split two...
The potential role of serum RBP4 and THBS2 as biomarker in colorectal cancer (CRC) diagnosis has never been studied. We investigated large sample using quantitative ELISA method to explore whether can act biomarkers for CRC diagnosis. concentration was measured 402 patients' samples 218 normal controls' samples. results showed that the average concentrations controls were significantly higher than patients (36.5±11.4μg/mL vs 21.8±8.7μg/mL 20.5±6.1ng/mL 14.5±7.3ng/mL, respectively), both...
Abstract Efficacy evaluation through human trials is crucial for advancing a vaccine candidate to clinics. Next-generation sequencing (NGS) can be used quantify B cell repertoire response and trace antibody lineages during vaccination. Here, we demonstrate this application with case study of Hecolin®, the licensed hepatitis E virus (HEV). Four subjects are administered following standard three-dose schedule. Vaccine-induced antibodies exhibit high degree clonal diversity, recognize five...
Abstract Bacillus coagulans has a potential role in improving intestinal injury. However, the specific mechanism is still unclear. In this study, protective effect of B. MZY531 on mucosa injury cyclophosphamide (CYP)-induced immunosuppressed mice were investigated. The results indicated that immune organ (thymus and spleen) indices treatment groups significantly increased compared to CYP group. administration promotes expression proteins (IgA, IgE, IgG, IgM). could upregulate ileum levels...
Abstract With the study of human diseases and biological processes increasing, a large number non-coding variants have been identified facilitated. The rapid accumulation genetic epigenomic information has resulted in an urgent need to collect process data explore regulation variants. Here, we developed comprehensive variation annotation database for (VARAdb, http://www.licpathway.net/VARAdb/), which specifically considers VARAdb provides 577,283,813 variations novel variants, prioritizes...
Abstract Background Renal cell carcinoma (RCC) is one of the most common malignant tumors originating from renal parenchymal urinary epithelial system. Tripartite motif 47 (TRIM47) a member TRIM family proteins, which has E3 ligase activity and been demonstrated to be involved in occurrence prognosis many tumors. The main purpose this study explore role potential mechanism TRIM47 promoting biological behavior RCC. Materials methods mRNA protein levels human cancer paired normal adjacent...
Coastal and nearshore zones, severing as a connection between the land open ocean, are some of most productive complex ecosystems, where prokaryotes abundant highly diverse. However, systematic study diversity on large-scale range in coastal zones is limited due to scattered sampling sites, various collection methods, different data processing methods across studies. Here, we provide dataset 16S rRNA gene sequences obtained from surface water samples China Seas, including Bohai Sea, Yellow...