A5000877894- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Research Studies
- Pancreatic and Hepatic Oncology Research
- Cancer-related molecular mechanisms research
- Peptidase Inhibition and Analysis
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Glycosylation and Glycoproteins Research
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Ferroptosis and cancer prognosis
- Anesthesia and Pain Management
- Hepatocellular Carcinoma Treatment and Prognosis
- Cell death mechanisms and regulation
- Dysphagia Assessment and Management
- Pain Management and Opioid Use
- Voice and Speech Disorders
- Video Surveillance and Tracking Methods
- Global Cancer Incidence and Screening
- Gut microbiota and health
- Metastasis and carcinoma case studies
- Lipid metabolism and disorders
Kaiser Permanente
2024-2025
Sun Yat-sen University
2009-2024
Sun Yat-sen University Cancer Center
2012-2024
State Key Laboratory of Oncology in South China
2009-2024
Xuzhou Medical College
2024
The First People’s Hospital of Lianyungang
2024
Center for Cancer Research
2024
Guangzhou Medical University
2015-2022
Nanchang University
2022
Nanjing University
2022
A nomogram is a useful and convenient tool for individualized cancer prognoses. We sought to develop clinical predicting survival of patients with resected non-small-cell lung (NSCLC).On the basis data from multi-institutional registry 6,111 NSCLC in China, we identified integrated significant prognostic factors build nomogram. The model was subjected bootstrap internal validation external separate cohort 2,148 International Association Study Lung Cancer (IASLC) database. predictive accuracy...
Purpose We investigated the correlation between number of examined lymph nodes (ELNs) and correct staging long-term survival in non–small-cell lung cancer (NSCLC) by using large databases determined minimal threshold for ELN count. Methods Data from a Chinese multi-institutional registry US SEER database on stage I to IIIA resected NSCLC (2001 2008) were analyzed relationship count migration overall (OS) multivariable models. The series mean positive LNs, odds ratios (ORs), hazard (HRs)...
Trajectory clustering, which aims at discovering groups of similar trajectories, has long been considered as a corner stone task for revealing movement patterns well facilitating higher-level applications like location prediction. While plethora trajectory clustering techniques have proposed, they often rely on spatiotemporal similarity measures that are not space- and time-invariant. As result, cannot detect clusters where the within-cluster occurs in different regions time periods. In this...
Approximately 30% of patients with stage IB non-small-cell lung cancer (NSCLC) die within 5 years after surgery. Current staging methods are inadequate for predicting the prognosis this particular subgroup. This study identifies prognostic markers NSCLC.We used computer-generated random numbers to 148 paraffin-embedded specimens immunohistochemical analysis. We studied gene expression in tissue from 73 randomly selected NSCLC who had undergone radical surgical resection and evaluated...
Comparative long-term survival and oncological outcomes for patients with non-small-cell lung cancer (NSCLC) who undergo video-assisted thoracic surgery (VATS) or conventional open lobectomy remain uncertain. We conducted a multi-institutional propensity-matched study to stratify potential differences in these outcomes. established registry 4312 NSCLC underwent between 2001 2008 from eight institutions the People's Republic of China. Age, gender, histological type tumour staging were entered...
Background. Long noncoding RNAs were involved in the processes of diabetes. Our study was aimed to explore clinical potential LncRNA NONRATT021972 diabetic neuropathic pain and investigate detailed mechanisms. Methods. 154 patients with type 2 diabetes enrolled as experimental group paired control. Patients without but neuropathy exclusive role neuropathy. Real-time PCR ELISA performed examine expression TNF- α flood. Neuropathic scores calculated data from NPQ. Streptozotocin used for SD...
Purpose: To compare the effectiveness and complication between microwave ablation lobectomy for stage I non-small cell lung cancer.Materials Methods: This retrospective study was approved by two institutional ethics committees all patients were provided with informed consent. From January 2000 to December 2010, 54 795 who underwent included in this study. A matched cohort composed of 108 group selected after adjustment 1:2 propensity score matching. The overall survival disease-free...
The effective segmentation and 3-D rendering of the esophagus esophageal cancer from computed tomography (CT) images can assist doctors in diagnosing cancer. Irregular vague boundary causes great difficulty In this paper, U-Net Plus is proposed to segment a 2-D CT slice. new network architecture, two blocks are employed enhance feature extraction performance complex abstract information, which effectively resolve irregular boundaries. A block skip connection operation that similar...
Abstract Objectives To develop and validate a radiomics model for evaluating treatment response to immune-checkpoint inhibitor plus chemotherapy (ICI + CT) in patients with advanced esophageal squamous cell carcinoma (ESCC). Methods A total of 64 advance ESCC receiving first-line ICI CT at two centers between January 2019 June 2020 were enrolled this study. Both 2D ROIs 3D segmented. ComBat correction was applied minimize the potential bias on results due different scan protocols. 788...
Nutritional evaluation is important for patients with esophageal cancer, but the impact of undernutrition on outcome those not well elucidated. Our aim to assess baseline nutritional status overall survival (OS) in Chinese squamous cell carcinoma (ESCC) and detect a most appropriate indicator evaluation.502 from Southern China diagnosed as ESCC Sun Yat-Sen University Cancer Center were included. A series indicators introduced evaluate status. Kaplan-Meier method was used estimate 5-year OS...
The current National Comprehensive Cancer Network (NCCN) guidelines for non-small cell lung cancer (NSCLC) recommend that surgeons sample is not clear. We aimed to define a minimal number of examined lymph nodes removal or sampling optimized nodal staging recommendation, with focus on T
Neuropathic pain is a nerve disorder characterized by the dysregulation of ion channels in dorsal root ganglion (DRG) neurons. MicroRNAs (miRs) may be associated with molecular mechanisms underlying altered levels channels; however, remain widely unknown. To investigate these mechanisms, present study conducted genomic analysis miR between unilateral spared injury (SNI) model and sham control. Differentially expressed miRs SNI groups were selected for transfection DRG cells, polymerase chain...
Concerns on surgical treatment of non-small cell lung cancer (NSCLC) have been increasing recent years. However, the significance previous studies based single center or regional experience in China was impaired by small sample size. Here we described a Chinese Multi-institutional Registry (CMIR) to address this disadvantage and proposed further collaboration project.Information patients diagnosed with stage I III NSCLC who underwent radical resection between 2001 2008 seven institutions...
The association between type 2 diabetes mellitus (T2DM) and the risk of esophageal cancer remains unclear. present study aimed to evaluate impact T2DM on short-term outcomes long-term survival in patients with squamous cell (ESCC).The retrospective included 862 diagnosed ESCC January 2001 December 2010. Among them, 280 had T2DM. A 1:1 propensity score-matched cohort consisting without was selected from patients. associations clinicopathologic characteristics were assessed using χ2 or...
To assess the feasibility and safety of video-assisted thoracoscopy surgery (VATS) systematic lymph node dissection in resectable non-small cell lung cancer (NSCLC).The clinical data patients with NSCLC who underwent VATS or thoracotomy combined lobectomy lymphadenectomy from January 2001 to 2008 were retrospectively analyzed identify their demographic parameters, number dissected nodes postoperative complications.A total 5,620 enrolled this study, 2,703 group, including 1,742 men (64.4%),...