A5013969270- Genomics and Chromatin Dynamics
- Statistical Methods and Bayesian Inference
- Gene expression and cancer classification
- Statistical Methods and Inference
- Chromosomal and Genetic Variations
- Asthma and respiratory diseases
- HIV Research and Treatment
- Bayesian Methods and Mixture Models
- Genomics and Phylogenetic Studies
- Neonatal Respiratory Health Research
- RNA Research and Splicing
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Air Quality and Health Impacts
- Advanced MRI Techniques and Applications
- HIV/AIDS drug development and treatment
- RNA modifications and cancer
- Statistical Methods in Clinical Trials
- Tuberculosis Research and Epidemiology
- Molecular Biology Techniques and Applications
- RNA and protein synthesis mechanisms
- Epigenetics and DNA Methylation
- Dialysis and Renal Disease Management
- Health Systems, Economic Evaluations, Quality of Life
- Genomic variations and chromosomal abnormalities
- Advanced Statistical Methods and Models
University of California, San Francisco
2015-2024
City College of San Francisco
2023
Stanford University
1989-2020
Cancer Research And Biostatistics
2002-2016
San Francisco State University
2014
University of California, Berkeley
2002-2013
San Francisco VA Medical Center
1991-2007
The University of Sydney
2007
Gladstone Institutes
2004
New York University
2002
It is uncertain whether the administration of benzodiazepines by paramedics an effective and safe treatment for out-of-hospital status epilepticus.
Both comorbid conditions and functional measures predict mortality in older adults, but few prognostic indexes combine both classes of predictors. Combining easily obtained into an accurate predictive model could be useful to clinicians advising patients, as well policy makers epidemiologists interested risk adjustment.To develop validate a index for 4-year using information that can from patient report.Using the 1998 wave Health Retirement Study (HRS), population-based study...
We studied the effect of prenatal maternal cigarette smoking on pulmonary function (PF) 80 healthy infants tested shortly after birth (mean, 4.2 ± 1.9 wk). Mothers' was measured by: (1) questionnaire reports at each visit number cigarettes smoked per day, and (2) urine cotinine concentrations (corrected for creatlnine) obtained visit. Infant PF assessed by partial expiratory flow-volume curves hellum-dilutlon measurement FRC. Forced flow rates were significantly lower in born to mothers,...
The regression-tree methodology is extended to right-censored response variables by replacing the conventional splitting rules with based on Tarone-Ware or Harrington-Fleming classes of two-sample statistics. New pruning strategies for determining desirable tree size are also devised. Properties this approach developed and comparisons existing procedures, in terms practical problems, discussed. Illustrative, real-world performances technique presented.
Dose-response curves to methacholine were examined in 9 normal and 10 asthmatic volunteers determine whether the relationship between dose response can be adequately summarized by means of a single, continuous measure that is not censored at lower levels bronchial responsiveness. Subjects underwent standard challenge test. There was strong linear percent decline FEV1 cumulative methacholine. We each dose-response curve slope line extending from origin last data point obtained. This summary...
To investigate whether cerebral blood volume (CBV), peak height (PH), and percentage of signal intensity recovery (PSR) measurements derived from the results T2-weighted dynamic susceptibility-weighted contrast material-enhanced (DSC) magnetic resonance (MR) imaging performed after external beam radiation therapy (EBRT) can be used to distinguish recurrent glioblastoma multiforme (GBM) necrosis.Fifty-seven patients were enrolled in this HIPAA-compliant institutional review board-approved...
<h3>Importance</h3> Precise stratification of cardiovascular risk in patients with coronary heart disease (CHD) is needed to inform treatment decisions. <h3>Objective</h3> To derive and validate a score predict outcomes among CHD, using large-scale analysis circulating proteins. <h3>Design, Setting, Participants</h3> Prospective cohort study participants stable CHD. For the derivation (Heart Soul study), outpatients from San Francisco were enrolled 2000 through 2002 followed up November 2011...
Abstract Random forests have emerged as a versatile and highly accurate classification regression methodology, requiring little tuning providing interpretable outputs. Here, we briefly outline the genesis of, motivation for, random forest paradigm an outgrowth from earlier tree‐structured techniques. We elaborate on aspects of prediction error attendant parameter issues. However, our emphasis is extending schema to multiple response setting. provide simple illustrative example ecology that...
Epidemiologic investigations into the natural history of airway obstructive disease have focused on both growth and decline lung function measurements. Although a general picture has emerged as to overall patterns growth/decline, uncertainty remains with regard important details these patterns. Pulmonary data from subjects aged 5 yr older who participated in any or all first 10 annual surveys East Boston population-based study been used investigate derived maximal forced expiratory...
Chromosomal translocations leading to chimeric oncoproteins are important in leukemogenesis, but how they form is unclear. We studied acute promyelocytic leukemia (APL) with the t(15;17) translocation that developed after treatment of breast or laryngeal cancer chemotherapeutic agents poison topoisomerase II.We used long-range polymerase chain reaction and sequence analysis characterize genomic breakpoints therapy-related APL. To determine whether II was directly involved mediating breaks...
MR image-guided gamma knife radiosurgery is often used to treat intra-axial metastatic neoplasms. Following treatment, it difficult determine whether a progressively enhancing lesion due tumor recurrence or radiation necrosis. The purpose of our study was relative cerebral blood volume (rCBV), peak height (rPH), and percentage signal-intensity recovery (PSR) derived from dynamic susceptibility-weighted contrast-enhanced perfusion imaging can distinguish recurrent necrosis.Twenty-seven...
Abstract The thrust of tree techniques is the extraction meaningful subgroups characterized by common covariate values and homogeneous outcome. For longitudinal data, this homogeneity can pertain to mean and/or covariance structure. regression methodology extended repeated measures data modifying split function so as accommodate multiple responses. Several functions are developed based either on deviations around subgroup vectors or two sample statistics measuring separation. methods be...
The risk of lung cancer as a result exposure to diesel exhaust from railroad locomotives was assessed in cohort 55,407 white male workers 40 64 yr age 1959 who had started service 10 20 years earlier. traced until the end 1980, and death certificates were obtained for 88% 19,396 deaths; 1,694 cases identified. Yearly job or retirement available Railroad Retirement Board, served an index exposure. Directly standardized rates proportional hazards model used calculate relative based on work...
A variety of new procedures have been devised to handle the two-sample comparison (e.g., tumor versus normal tissue) gene expression values as measured with microarrays. Such methods are required in part because some defining characteristics microarray-based studies: (i) very large number genes contributing measures which far exceeds samples (observations) available and (ii) fact that by virtue pathway/network relationships, tend be highly correlated. These concerns exacerbated regression...
Background and objectives Frailty is common among patients on hemodialysis associated with adverse outcomes. However, little known about changes in frailty over time the factors those changes. Design, setting, participants, & measurements To address these questions, we examined 762 participants A Cohort to Investigate Value of Exercise/Analyses Designed Paradox Obesity Survival ESRD cohort study, whom was assessed at baseline 12 24 months. We used ordinal generalized estimating equations...
More efficacious treatment regimens are needed for tuberculosis, however, drug development is impeded by a lack of reliable biomarkers disease severity and effect. We conducted directed screen host in participants enrolled tuberculosis clinical trial to address this need. Serum samples from 319 protocol-correct, culture-confirmed pulmonary patients treated under direct observation as part an international, phase 2 were screened 70 markers infection, inflammation, metabolism. Biomarker assays...
Repair of a chromosomal double-strand break (DSB) by gene conversion depends on the ability broken ends to encounter donor sequence. To understand how location target sequence affects DSB repair, we took advantage genome-wide Hi-C analysis yeast chromosomes create series strains in which an induced site-specific budding is repaired 2-kb inserted at different locations. The efficiency measured cell viability or competition between each and reference site, showed strong correlation (r = 0.85...