A5062650714- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Tracheal and airway disorders
- Radiomics and Machine Learning in Medical Imaging
- Pleural and Pulmonary Diseases
- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Lung Cancer Research Studies
- Metastasis and carcinoma case studies
- Salivary Gland Tumors Diagnosis and Treatment
- RNA modifications and cancer
- Cancer Diagnosis and Treatment
- Head and Neck Cancer Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Medical Imaging and Pathology Studies
- Cancer Immunotherapy and Biomarkers
- Congenital Diaphragmatic Hernia Studies
- MicroRNA in disease regulation
- Monoclonal and Polyclonal Antibodies Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Esophageal and GI Pathology
- Cardiac tumors and thrombi
China-Japan Friendship Hospital
2016-2025
Peking University
2016-2021
Zhejiang University
2017-2021
First Affiliated Hospital Zhejiang University
2021
First Affiliated Hospital of Guangzhou Medical University
2017-2020
State Key Laboratory of Respiratory Disease
2015-2020
Guangzhou Medical University
2015-2020
Peking Union Medical College Hospital
2019
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2019
Roswell Park Comprehensive Cancer Center
2019
A nomogram is a useful and convenient tool for individualized cancer prognoses. We sought to develop clinical predicting survival of patients with resected non-small-cell lung (NSCLC).On the basis data from multi-institutional registry 6,111 NSCLC in China, we identified integrated significant prognostic factors build nomogram. The model was subjected bootstrap internal validation external separate cohort 2,148 International Association Study Lung Cancer (IASLC) database. predictive accuracy...
Purpose We investigated the correlation between number of examined lymph nodes (ELNs) and correct staging long-term survival in non–small-cell lung cancer (NSCLC) by using large databases determined minimal threshold for ELN count. Methods Data from a Chinese multi-institutional registry US SEER database on stage I to IIIA resected NSCLC (2001 2008) were analyzed relationship count migration overall (OS) multivariable models. The series mean positive LNs, odds ratios (ORs), hazard (HRs)...
Comparative long-term survival and oncological outcomes for patients with non-small-cell lung cancer (NSCLC) who undergo video-assisted thoracic surgery (VATS) or conventional open lobectomy remain uncertain. We conducted a multi-institutional propensity-matched study to stratify potential differences in these outcomes. established registry 4312 NSCLC underwent between 2001 2008 from eight institutions the People's Republic of China. Age, gender, histological type tumour staging were entered...
Abstract Lung cancer is the most common incident cancer, with a high mortality worldwide, and non‐small‐cell lung (NSCLC) accounts for approximately 85% of cases. Numerous studies have shown that aberrant expression microRNAs (miRNAs) associated development progression cancers. However, clinical significance biological roles miRNAs in NSCLC remain elusive. In this study, we identified novel miRNA, miR‐34b‐3p, suppressed cell growth investigated underlying mechanism. miR‐34b‐3p was...
Sublobar resection has emerged as an alternative to lobectomy for management of early-stage non-small cell lung cancer (NSCLC). However, controversy remains whether it is adequate elderly patients. The present study aimed comparatively the perioperative outcomes and overall survival sublobar
Background: The platelet-to-lymphocyte ratio (PLR) is a useful predictive factor in several cancers. However, the prognostic value of PLR patients with non-small-cell lung cancer (NSCLC) still indistinct. Therefore, it was necessary for us to perform meta-analysis assess NSCLC. Methods: A systematic literature search performed by using PubMed, EMBASE, and Web Science databases relevant studies until May 2015. Published investigating association between overall survival (OS) disease-free...
// Naiqing Xu 1,2,3,* , Wenfeng Fang 4,* Libing Mu 5 Yanna Tang 4 Lei Gao 2 Shengxiang Ren 6 Dengfeng Cao 7 Lixin Zhou 8 Aiqun Zhang 9 Deruo Liu 10 Caicun Kwok-Kin Wong 11 Yu 12 Li and Liang Chen 1,2,3,13 1 Graduate School of Peking Union Medical College, Beijing, China National Institute Biological Sciences, 3 Chinese Academy Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Center, Guangzhou, Guangdong, P. R. Tsinghua Shanghai Pulmonary Hospital, Shanghai,...
Anti-HER2/neu antibody therapy has been reported to mediate tumor regression of HER2/ neu+ tumors. Here we demonstrated the expression HER2 in a wide range human melanoma cells including primary culture and seven cell lines, further investigated whether could be served as target for T mediated immunotherapy melanoma. Specific cytolytic activity activated (ATC) armed with anti-CD3 x anti-HER2 bispecific (HER2Bi-Ab) against Malme-3M-luc was evaluated by bioluminescent signal generated...
Lung cancer is one of the most common cancers in word. However, underlying mechanism remains largely unknown. ACOT11 encodes enzymes hydrolyzing fatty acyl-CoA esters into free acids and CoA. Besides from its role acid metabolism, other aspects regarding function progression lung have not been revealed.We first explored clinical profile tumor samples. Next, we combined gene knockdown vitro vivo microarray profiling analysis to decipher unknown regulatory carcinoma. Furthermore, potential...
Spread through air space (STAS) is a risk factor for disease recurrence in patients with stage IA lung adenocarcinoma (LUAD) who undergo limited resection. Preoperative prediction of STAS could help intraoperative surgical decision-making small LUAD patients. The aim the study was to evaluate predictive value radiological features on cIA LUAD.A case-control designed retrospective analysis underwent curative surgery clinical tumor size ≤3 cm. Univariable and multivariable analyses were used...
The aim of this study was to compare the surgical efficacy one-stage and two-stage video-assisted thoracoscopic surgery (VATS) for bilateral multiple pulmonary nodules (BMPNs). A retrospective analysis made 156 patients, 84 who underwent 72 VATS BMPNs at our department between January 2019 December 2022. Perioperative long-term outcomes were compared two groups using propensity score-matched (PSM) analysis. There 48 patients in each group after PSM. No significant difference observed...
To study risk factors that affect the evaluation of malignancy in patients with solitary pulmonary nodules (SPN) and verify different predictive models for malignant probability SPN.Retrospectively analyzed 107 cases SPN definite post-operative histological diagnosis whom underwent surgical procedures China-Japan Friendship Hospital from November 2010 to February 2013. Age, gender, smoking history, history patients, imaging features nodule including maximum diameter, position, spiculation,...
This study aimed to determine whether the severity of chronic obstructive pulmonary disease (COPD) affects recurrence-free survival in non-small-cell lung cancer (NSCLC) patients after surgical resection.A retrospective was performed on 421 consecutive who had undergone lobectomy for NSCLC from January 2008 June 2011. Classification COPD based guidelines Global Initiative Chronic Obstructive Lung Disease (GOLD). Characteristics among three subgroups were compared and survivals analyzed.A...
It is difficult to achieve a margin-negative resection (R0) for non-small cell lung cancer (NSCLC) patients with infiltration of the pulmonary artery. We report our experience artery reconstruction regard long-term survival.Clinical records 118 NSCLC who underwent partial or circumferential during 21-year period were reviewed retrospectively. Techniques and survival outcomes analyzed.We performed 22 sleeve resections, 51 reconstructions by autologous pericardial patch, 36 tangential 3 left...