A5061807115- Gout, Hyperuricemia, Uric Acid
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Cancer-related molecular mechanisms research
- Inflammasome and immune disorders
- Ferroptosis and cancer prognosis
- Tea Polyphenols and Effects
- Liver Disease Diagnosis and Treatment
- Cardiac Ischemia and Reperfusion
- Anesthesia and Neurotoxicity Research
- Circular RNAs in diseases
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Chemotherapy-induced cardiotoxicity and mitigation
- Immune Response and Inflammation
- Immune cells in cancer
- Neuroscience and Neuropharmacology Research
- Orthopedic Surgery and Rehabilitation
- Sexual Differentiation and Disorders
- Tracheal and airway disorders
- Medicinal Plants and Neuroprotection
- Autophagy in Disease and Therapy
- Airway Management and Intubation Techniques
- Alcohol Consumption and Health Effects
- Image and Signal Denoising Methods
Hubei University of Science and Technology
2006-2025
Xiamen University
2020-2024
Harbin Medical University
2013-2023
Fourth Affiliated Hospital of Harbin Medical University
2018-2023
Peking University First Hospital
2021-2023
Peking University
2021-2023
Union Hospital
2017-2022
Jilin University
2017-2022
First Affiliated Hospital of Nanchang University
2020
Nanchang University
2020
Atherosclerotic vascular disease (ASVD) is the leading cause of death worldwide. Hyperuricemia fourth risk factor for atherosclerosis after hypertension, diabetes, and hyperlipidemia. The mechanism hyperuricemia affecting occurrence development has not been fully elucidated. Mononuclear macrophages play critical roles in all stages atherosclerosis. Studies have confirmed that both ferroptosis promote atherosclerosis, but whether high level uric acid (HUA) promotes by regulating remains...
Uric acid is the end metabolite derived from oxidation of purine compounds. Overwhelming evidence shows vital interrelationship between hyperuricemia (HUA) and nonalcoholic fatty liver disease (NAFLD). However, mechanisms for this association remain unclear. In study, we established a urate oxidase-knockout (Uox-KO) mouse model by clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 technology. To study correlation HUA NAFLD, human HepG2 hepatoma cells were treated in...
Doxorubicin (DOX) is a most common anthracycline chemotherapeutic agent; however, its clinical efficacy limited due to severe and irreversible cardiotoxicity. Ferroptosis, characterized by iron overload lipid peroxidation, plays pivotal role in DOX-induced Resveratrol (RSV) displays cardioprotective anticancer effects, owing antioxidative anti-inflammatory properties. However, the mechanism of RSV DOX-mediated ferroptosis cardiomyocytes unclear. This study showed that DOX decreased cell...
Introduction Piper kadsura is a well-known medicinal plant that belongs to woody liana, possessing high therapeutic and economic value. The market demand of P. huge, but its wild resources are scarce artificial cultivation methods have not been established, which leads situation with strong contradiction imbalance between supply demand. Methods In this study, 303 sample distribution data for in China were collected, 33 environmental variables related terrain, climate soil analyzed the...
Carvacrol (CAR), a naturally occurring phenolic monoterpene, has been shown to possess diverse biological activities. The present study was undertaken evaluate the cardioprotective potential of CAR against myocardial ischemic damage in rat model acute infarction. significantly diminished infarct size and enzymes including creatine kinase (CK), MB isoenzyme (CK-MB), lactate dehydrogenase (LDH) cardiac troponin T (cTnT). Reduced level malondialdehyde (MDA), obviously elevated activities...
Hypoxia‐induced neuroinflammation typically causes neurological damage and can occur during stroke, neonatal hypoxic‐ischemic encephalopathy, other diseases. Propofol is widely used as an intravenous anesthetic. Studies have shown that propofol has antineuroinflammatory effect. However, the underlying mechanism remains to be fully elucidated. Thus, we aimed investigate beneficial effects of against hypoxia‐induced elucidated its potential cellular biochemical mechanisms action. In this...
High uric acid (HUA), as a pro-oxidant, plays significant role in the pathophysiology of cardiovascular disease. Studies have indicated that elevated levels can adversely affect health. Nevertheless, impact hyperuricemia on cardiomyopathy remains uncertain. Further research is needed to elucidate relationship between HUA and cardiomyopathy, shedding light its potential implications for heart
Theaflavin, a major constituent of black tea, possesses biological functions such as the antioxidative, antiviral, and anti-inflammatory ones. The purpose this study was to verify whether theaflavin reduces focal cerebral ischemia injury in rat model middle artery occlusion (MCAO). Male Sprague-Dawley rats were anesthetized subjected 2 hours MCAO followed 24 reperfusion. Theaflavin administration (5, 10, 20 mg/kg, i.v.) ameliorated infarct edema volume. inhibited leukocyte infiltration...
Aim Numerous reports have demonstrated the key importance of macrophage-elicited metabolic inflammation in insulin resistance (IR). Our previous studies confirmed that hyperuricemia or high uric acid (HUA) treatment induced an IR state several peripheral tissues to promote development type 2 diabetes mellitus (T2DM). However, effect HUA on glucose uptake and sensitivity macrophages its mechanism is unclear. Methods To assess systemic IR, we generated hyperuricemic mice by urate oxidase...
Traumatic brain injury (TBI) can result in motor and cognitive dysfunction is a possible risk factor for the subsequent development of dementia. However, pathogenesis TBI remains largely unclear. This study investigated roles long non-coding RNAs (lncRNAs) microRNAs (miRNAs) inflammation neuronal apoptosis following TBI.The lncRNA expression profiles cerebral cortices model mice sham-operated were analyzed using microarray. We focused on an upregulated lncRNA, PRR34-AS1, because its known...
Propofol is a known intravenous hypnotic drug used for induction and maintenance of sedation general anesthesia. Emerging studies also reveal neuroprotective effect propofol in diverse diseases neuronal injuries via modulating microglia activation. In this study, we aimed to uncover the downstream targets process.RNA sequencing analysis identify genes implicated propofol-mediated effect. Quantitative real-time PCR, enzyme-linked immunosorbent assay, Western blotting were performed analyze...
Theaflavin, a major constituent of black tea, possesses biological functions such as the antioxidative, antiviral, and anti-inflammatory ones. The purpose this study was to verify whether theaflavin reduces focal cerebral ischemia injury in rat model middle artery occlusion (MCAO). Male Sprague-Dawley rats were anesthetized subjected 2 hours MCAO followed 24 reperfusion. Theaflavin administration (5, 10, 20 mg/kg, IV) ameliorated infarct edema volume. inhibited leukocyte infiltration...
Objective Bronchopulmonary dysplasia (BPD) is a pulmonary injury related to inflammation and major cause of premature infant death. Long noncoding RNAs (lncRNAs) are important regulators in inflammation. We investigated the molecular mechanism lncRNA H19 hyperoxia (Hyp)-induced BPD mice. Study Design The newborn mouse model was established intervened with evaluate pathologic conditions radial alveolar count (RAC) lung tissues mice room air (RA) Hyp group on 4th, 7th, 14th days after birth....