A5103108854- Acne and Rosacea Treatments and Effects
- Dermatologic Treatments and Research
- melanin and skin pigmentation
- Pharmacological Effects of Natural Compounds
- Skin Protection and Aging
- Cancer-related molecular mechanisms research
- Herpesvirus Infections and Treatments
- Music History and Culture
- Leprosy Research and Treatment
- Endometriosis Research and Treatment
- Flavonoids in Medical Research
- Transplantation: Methods and Outcomes
- Dermatology and Skin Diseases
- Telomeres, Telomerase, and Senescence
- Phytochemistry and Biological Activities
- Global Education and Multiculturalism
- Bone Metabolism and Diseases
- Reproductive System and Pregnancy
- Theater, Performance, and Music History
- Cancer Treatment and Pharmacology
- Chinese history and philosophy
- Plant-based Medicinal Research
- RNA modifications and cancer
- Asian Culture and Media Studies
- Circular RNAs in diseases
Xiangya Hospital Central South University
2018-2025
Central South University
2018-2025
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
2024
State Administration of Traditional Chinese Medicine of the People's Republic of China
2024
Harbin Medical University
2023
Fourth Affiliated Hospital of Harbin Medical University
2023
First Affiliated Hospital of Zhengzhou University
2019
Soochow University
2017
First Affiliated Hospital of Soochow University
2017
Abstract Rosacea is a common chronic skin disorder of unknown etiology. While population prevalence rates range 0.2–22% in Europe and North America, China currently undetermined. We conducted large population‐based case–control study to determine the present epidemiological status rosacea China, involving 10 095 participants aged 0–100 years (mean age, 35.5 ± 19.1; 50.5% female). A census among 15 communities Changsha south central was with examination by board‐certified dermatologists....
Esophagus cancer is the seventh causes of cancer-related deaths globally. In this study, we analyzed IL-6 gene expression in human esophagus patients, and showed that mRNA levels are significantly higher tumor tissues negatively correlated with overall survival, suggesting a potential therapeutic target for cancer. We further demonstrated apigenin, nature flavone product green plants, inhibited transcription Eca-109 Kyse-30 cells. Apigenin dose-dependently cell proliferation, promoted...
Rosacea is a chronic inflammatory disease in face. Hydroxychloroquine (HCQ), an anti-malaria drug, was reported to have anti-inflammation activities. However, the role of HCQ on rosacea remains unclear. In this study, we revealed potential molecular mechanism by which improved rosacea-like mice and mast cells (MCs). Moreover, effects treatment for patients were investigated. found ameliorated phenotype MCs infiltration. The elevated pro-inflammatory factors cell protease significantly...
The purpose of this study is to examine preservice Chinese language teachers' cognition in teaching intercultural communicative competence. In the we collected data through in-depth interviews with seven teachers a Master Education program (Teaching as Second Language, TCSL) at university Hong Kong SAR, China. findings indicated that participants had relatively positive attitude and inclination toward development students' competence, while their conceptualizations culture tended be static...
Rosacea patients show facial hypersensitivity to stimulus factors (such as heat and capsaicin); however, the underlying mechanism of this hyperresponsiveness remains poorly defined. Here, we capsaicin stimulation in mice induces exacerbated rosacea-like dermatitis but has no apparent effect on normal skin. Nociceptor ablation substantially reduces dermatitis. Subsequently, find that γδ T cells express Ramp1, receptor neuropeptide CGRP, are close contact with these nociceptors significantly...
Rosacea is a common chronic facial disorder that affects patients' health-related quality of life; the only questionnaire designed specifically for rosacea Rosacea-specific Quality-of-Life instrument (RosQol). However, has not been validated among Chinese patients. This study aimed to validate version RosQol. First, we translated into Chinese. Then, patients completed RosQol and Dermatology Life Quality Index, indicating disease's impact on their lives. We also collected demographic clinical...
ABSTRACT Background Post‐laser melasma induction/exacerbation remains a critical challenge in treating acquired bilateral nevus of Ota‐like macules (ABNOMs). While laser parameters are well‐studied, patient‐specific risk factors across evolving therapeutic eras require elucidation. Methods This retrospective cohort analyzed 2675 ABNOMs patients treated with Q‐switched lasers two eras: C1 (2010–2013; 1064 nm‐only, n = 1069) and C2 (2020–2023; multi‐wavelength, 1606). Risk were assessed...
Non-coding small RNAs are involved in organism development, and their aberrant regulation induces various diseases, including hepatocellular carcinoma (HCC), but exact mechanisms have not been determined.The aim was to investigate the role of miR-142-3p on HMGB1 expression carcinoma.Expression levels HCC tissues cultured cells were measured by RT-PCR. The invasion metastasis abilities HepG2 according Transwell migration assays, protein western blotting.The present study reported that...
Traumatic brain injury (TBI) can result in motor and cognitive dysfunction is a possible risk factor for the subsequent development of dementia. However, pathogenesis TBI remains largely unclear. This study investigated roles long non-coding RNAs (lncRNAs) microRNAs (miRNAs) inflammation neuronal apoptosis following TBI.The lncRNA expression profiles cerebral cortices model mice sham-operated were analyzed using microarray. We focused on an upregulated lncRNA, PRR34-AS1, because its known...
Background: Rosacea is a common facial skin inflammatory disease featured by hyperactivation of mTORC1 signaling in the epidermis. Due to unclear pathogenesis, effective treatment options for rosacea remain limited. Methods: Weighted gene co-expression network analysis (WGCNA) analyzed relationship between epidermis autophagy and mTOR pathways rosacea, further demonstrated it through immunofluorescence qPCR analysis. A potential therapeutic agent was predicted based on key genes WGCNA...
Abstract The aim of this study was to investigate the protective effect fluorofenidone (5‐methyl‐1‐[3‐fluorophenyl]‐2‐[1H]‐pyridone, AKF‐PD) on ultraviolet (UV)‐A‐induced senescence in human dermal fibroblasts (HDF) and examine mechanisms involved. HDF were treated with AKF‐PD. Senescence‐associated (SA)‐β‐galactosidase level, cell viability expression p16 evaluated. In addition, UV‐A‐irradiated AKF‐PD, rapamycin MHY1485; SA‐β‐galactosidase staining, 3‐(4 5‐dimethylthiazol‐2‐yl)‐2...
Botulinum toxin (BTX) is a new treatment approach primarily aimed at relieving flushing and erythema for rosacea, but it expensive lacks economic benefit evaluation studies.This study to investigate willingness-to-pay (WTP) of BTX conduct benefit-cost analysis (BCA) assess if rosacea recommendable from viewpoint economics in China.WTP information sociodemographic clinical characteristics were inquired via an online questionnaire among the Chinese patients. The WTP was by photos three cases...
<sec> <title>BACKGROUND</title> Rosacea is a chronic inflammatory dermatosis with facial skin involved, leading to physical and emotional problems, which greatly affected quality of life (QoL) patients. Dermatology Life Quality Index (DLQI) willingness pay (WTP) are well-established instruments assessing the health-related (HRQoL), while very few studies have been focused on this topic about rosacea in China. </sec> <title>OBJECTIVE</title> To investigate HRQoL Chinese patients assessed by...