A5100391121- Congenital Heart Disease Studies
- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- Cardiac Structural Anomalies and Repair
- Pulmonary Hypertension Research and Treatments
- Cardiovascular Health and Disease Prevention
- Blood Pressure and Hypertension Studies
- Cardiac electrophysiology and arrhythmias
- Cryospheric studies and observations
- Tracheal and airway disorders
- Virology and Viral Diseases
- Heart Rate Variability and Autonomic Control
- Arctic and Antarctic ice dynamics
- Cardiac Imaging and Diagnostics
- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Viral Infections and Vectors
- Coronary Artery Anomalies
- Pediatric Hepatobiliary Diseases and Treatments
- Mechanical Circulatory Support Devices
- Advanced X-ray and CT Imaging
- Vascular anomalies and interventions
- Coronary Interventions and Diagnostics
- Thermoregulation and physiological responses
- Ion channel regulation and function
Shanghai Jiao Tong University
2016-2025
Shanghai Children's Medical Center
2014-2025
McGill University
2022-2025
Ruijin Hospital
2022-2025
Regend Therapeutics (China)
2025
Guangzhou Medical University
2025
International Peace Maternity & Child Health Hospital
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Peking Union Medical College Hospital
2024
Cangzhou Central Hospital
2022
Traditional treatment therapies for tracheal stenosis often cause severe post-operative complications. To solve the current difficulties, novel and more suitable long-term treatments are needed. A whole-segment tissue-engineered trachea (TET) representing native goat was 3D printed using a poly(caprolactone) (PCL) scaffold engineered with autologous auricular cartilage cells. The TET underwent mechanical analysis followed by in vivo implantations order to evaluate clinical feasibility...
Flavonoid-enriched extract from Hippophae rhamnoides L. (Elaeagnaceae) seed (FSH) has shown beneficial effects in anti-hypertension and lowering cholesterol level. However, evidence for its efficacy treating obesity is limited.
Paramyxovirus membrane fusion requires an attachment protein for receptor binding and a triggering. Nipah virus (NiV) (G) binds to ephrinB2 or -B3 receptors, (F) mediates fusion. NiV-F is class I activated by endosomal cleavage. The crystal structure of soluble GCN4-decorated shows hexamer-of-trimer assembly. Here, we used single-molecule localization microscopy quantify the distribution organization on cell virus-like particle membranes at nanometer precision. We found that biological forms...
<title>Abstract</title> Objective: To investigate the correlation between healthy vascular aging (HVA) and non-healthy (NHVA) with hypertensive target organ damage (TOD). Methods: This study included individuals from Geriatrics Department of Ruijin Hospital in Shanghai since January 2023. Participants were divided into HVA NHVA groups based on blood pressure carotid-femoral pulse wave velocity (cf-PWV). was defined as no history hypertension cf-PWV < 7.6 m/s; a or ≥ m/s. Hypertensive TOD...
Bacterial endocarditis is a fatal cardiovascular disease exacerbated by weakened heart contraction, yet the direct impact of cardiac contractility on bacterial adhesion remains elusive. Here, we present novel quantitative physics model integrating finite element analysis and live-cell imaging to uncover their strong correlation. Using this model, quantified real-time force magnitude generated organoid-type microtissue derived from healthy donors dilated cardiomyopathy patients – mimicking...
<title>Abstract</title> Blood glucose (BG) detection is of great importance for diabetes prevention in healthy individuals. However, the traditional invasive methods have disadvantages, such as causing pain and inconvenience. Additionally, BG changes can disrupt balance autonomic nervous system, which be evaluated using heart rate variability (HRV). For these reasons, this study aims to develop a non-invasive level method based on HRV. This proposed dynamic static fluctuation analysis...
Background Activin receptor-like kinase 4 ( ALK 4) is highly expressed in mammal heart. Atrial fibrillation AF ) closely related to ventricular pressure overload. Because overload increases atrial and leads remodeling, it would be informative know whether exerts potential effects on remodeling vulnerability a pressure-overload model. Methods Results Wild-type littermates 4+/- mice were subjected abdominal aortic constriction or sham operation. After 8 weeks, echocardiographic hemodynamic...
This study aimed to assess the severity of helix and vortex flow in pulmonary artery hemodynamic using 4-dimensional cardiac magnetic resonance (4D CMR) patients with repaired tetralogy Fallot (rTOF) healthy child volunteers explore relationship between changes right heart function.CMR studies were performed 25 rTOF (15 M/10 F; 8.44±4.52 years) 10 normal (7 M/3 8.2±1.22 on 3.0T MR scanners. Cardiac function was calculated patient control groups. Systolic diameter, peak velocity, net flow,...
Background: Rosacea is a common facial skin inflammatory disease featured by hyperactivation of mTORC1 signaling in the epidermis. Due to unclear pathogenesis, effective treatment options for rosacea remain limited. Methods: Weighted gene co-expression network analysis (WGCNA) analyzed relationship between epidermis autophagy and mTOR pathways rosacea, further demonstrated it through immunofluorescence qPCR analysis. A potential therapeutic agent was predicted based on key genes WGCNA...
This study introduced a combined computational fluid dynamics (CFD) and echocardiography methodology to simulate blood flow in the single right ventricle (SRV) normal ventricles intraventricular flow. Derived from echocardiographic image loops, CFD-based three-dimensional (3D) models of subject's left (LV) (RV) SRV with without heart failure at three characteristic diastolic statuses were reconstructed. The CFD derived morphological functional measurements validated echocardiography. vortex...
The aim of the present study was to investigate executive function inhibitory control in anorexia nervosa (AN), which is considered as an underlying pathophysiology restricting eating. In this work, we examined response inhibition 27 unmedicated AN patients and 30 healthy controls (HC) using stop-signal tasks with different demand loads. Two event-related potentials (ERP) during tasks, N2 P300, were compared between HC groups. We found attenuated P300 amplitudes delayed latencies across all...
Abstract Sleep deprivation (SD) is observed to adversely affect the reproductive health of women. However, its precise physiological mechanisms remain largely elusive. In this study, using a mouse model SD, it demonstrated that SD induces depletion ovarian primordial follicles, phenomenon not attributed immune‐mediated attacks or sympathetic nervous system activation. Rather, excessive secretion stress hormones, namely norepinephrine (NE) and epinephrine (E), by overactive adrenal glands,...
Paramyxovirus membrane fusion requires an attachment protein for receptor binding and a triggering. Nipah virus (NiV) (G) binds to ephrinB2 or -B3 receptors, (F) mediates fusion. NiV-F is class I activated by endosomal cleavage. The crystal structure of soluble GCN4-decorated shows hexamer-of-trimer assembly. Here, we used single-molecule localization microscopy quantify the distribution organization on cell virus-like-particle membranes at nanometer precision. We found that biological forms...
Absent pulmonary valve is a rare cardiovascular anomaly that can result in profound tracheobronchial compression.To demonstrate the advantage of multi-slice CT diagnosing compression, its severity as related to adjacent dilated arteries, and associated lung cardiac lesions.We included children with absent who were reviewed by during 17-year period. The number locations stenoses lesions noted stenosis was categorized. diameter artery measured defects demonstrated.Thirty-one (14 girls 17 boys)...
Modified Blalock–Taussig (mB–T) shunt is an effective palliative surgical method in the treatment of cyanotic congenital heart diseases. Although technique has improved over years, it still a challenge to control appropriate blood flow through conduit. The formation thrombosis conduit after mB–T may lead severe desaturation or reoperation some cases. Here, we applied computational fluid dynamics (CFD) study patient-specific case based on medical images shunt. real-time velocities derived...
Abstract: Sebaceous hyperplasia is a common, benign condition of the sebaceous glands in adults middle age or older, occurring primarily on face and neck. In adolescent young adult patients, it rare entity called premature (PSH). Previous reports indicate that onset PSH occurs during shortly after puberty, with an average age‐at‐onset 19 years. Here we present extremely prepubescent case developed right side boy’s neck when he was 8 years old.
The objective of this study was to analyze the echocardiographic characteristics juxtaposition atrial appendages and determine its prevalence in children with congenital heart disease. From June 1998 December 2008, 10,880 underwent selective angiocardiography, magnetic resonance imaging (MRI), echocardiography for evaluation Juxtaposition diagnosed based on results angiocardiography MRI; anomaly were analyzed retrospectively. There 33 patients right appendage (JRAA); no patient left...