A5066034390- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Cardiac pacing and defibrillation studies
- Ion channel regulation and function
- Cardiac Fibrosis and Remodeling
- Photonic Crystal and Fiber Optics
- Heart Rate Variability and Autonomic Control
- MicroRNA in disease regulation
- Optical Network Technologies
- Blood Pressure and Hypertension Studies
- Advanced Fiber Optic Sensors
- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Safety and Risk Management
- Advanced Fiber Laser Technologies
- Lipoproteins and Cardiovascular Health
- TGF-β signaling in diseases
- Circular RNAs in diseases
- Receptor Mechanisms and Signaling
- Cardiovascular Disease and Adiposity
- Cardiovascular Effects of Exercise
- Advanced Photonic Communication Systems
- Angiogenesis and VEGF in Cancer
- Human Mobility and Location-Based Analysis
XinHua Hospital
2016-2025
Shanghai Jiao Tong University
2016-2025
China National Petroleum Corporation (China)
2025
Hubei Engineering University
2024
National Earthquake Response Support Service
2009-2024
Nankai University
2001-2024
Children's Hospital of Pittsburgh
2023-2024
University of Pittsburgh
2023-2024
Clarion University
2023-2024
Lund University
2023-2024
Catheter-based pulmonary artery denervation (PADN) has achieved promising outcomes to treat hypertension (PH). We herein present stereotactic body radiotherapy (SBRT) as a novel noninvasive approach for PADN. A single fraction of 15 Gy, 20 Gy or 25 was delivered PADN in thromboxane A2 (TxA2) - induced acute PH swine model. demonstrated that by 20-Gy SBRT reduced mean (PA) pressure during the TxA2 challenge. All dosages led deeper area compared with radiofrequency ablation (RFA) and...
Pulmonary veins (PVs) can be completely isolated with continuous circular lesions (CCLs) around the ipsilateral PVs. However, electrophysiological findings have not been described in detail during ablation of persistent atrial fibrillation (AF).Forty patients symptomatic AF underwent complete isolation right-sided and left-sided PVs guided by 3D mapping double Lasso technique AF. Irrigated was initially performed CCLs subsequently CCLs. After both lateral PVs, stable sinus rhythm achieved...
CXCR2 plays a key role in protecting the integrity of endothelium. Emerging evidence has demonstrated that long ncRNAs (lncRNA) Human metastasis associated lung adenocarcinoma transcript 1 (MALAT1) participates regulation pathophysiological processes. However, whether there is crosstalk between and MALAT1 remains unknown. In this study, we was upregulated patients with unstable angina. silencing significantly downregulated expression miR‐22‐3p target gene via reversing effect miR‐22‐3p,...
Systemic light chain amyloidosis is a rare and debilitating disease, especially for which initially presented with digestive tract involvement. Myocardial highly aggressive generally poor prognosis often resulted in missed diagnosis or misdiagnosis routine examination tools. Multimodality imaging play an important role diagnosing the effect on multiple organs. Chemoradiotherapy mainstay of treatment. This article presents case systemic amyloidosis, gastrointestinal symptoms, 68-year-old...
The stability of cement slurries under high-temperature conditions poses a significant engineering challenge in cementing operations. This study explored the development novel tetrameric thermosensitive thickening polymer (TTSTC) as solution to this problem. Aqueous free radical polymerization was employed synthesize polymer. base monomers 2-acrylamido-2-methylpropanesulfonic acid (AMPS) and acrylamide (AM) were employed, conjunction with long-chain octadecyldimethylallylammonium chloride...
Dysfunction of endothelial progenitor cells (EPCs) contributes to diabetic vascular disease. MicroRNAs (miRs) have emerged as key regulators diverse cellular processes including angiogenesis. We recently reported that miR-126, miR-130a, miR-21, miR-27a, and miR-27b were downregulated in EPCs from type II diabetes mellitus (DM) patients, downregulation miR-126 impairs EPC function. The present study further explored whether dysregulated miR-130a also related dysfunction. cultured peripheral...
Abstract The biological effects of microRNAs (miRNAs) and TNF-α in atherosclerosis have been widely studied. circulating miR-17-92 cluster has recently shown to be significantly downregulated patients with injured vascular endothelium. However, it remains unclear whether the plays a significant role endothelial repair. aim this study was investigate relationship between TNF-α-induced cell apoptosis. We determined that down-regulation miR-19b level among coronary artery disease consistent...
Background/Aims: MicroRNAs play regulatory role in cardiovascular disease. MicroRNA-223 (miR-223) was found to be expressed abundantly myocardium. TNNI3K, a novel cardiac troponin I (cTnI)-interacting and hypertrophy related kinase, is computationally predicted as potential target of miR-223. This study designed investigate the cellular molecular effects miR-223 on cardiomyoctye hypertrophy, focusing TNNI3K. Methods: Neonatal rat cardiomyocytes (CMs) were cultured, CMs induced by...
Abstract Endothelial‐to‐mesenchymal transition (EndMT) was first reported in heart development. Recent studies have shown that EndMT also occurs the progression of cardiac fibrosis. Herein, we demonstrated a critical role Forkhead Box M1 (Foxm1) transcription factor transforming growth beta (TGF‐β)‐induced endothelial cells (ECs) and possible underlying molecular mechanism. Foxm1 induced ECs following TGF‐β stimulation. Using both pharmacological approaches to inhibit function can attenuate...
Atrial fibrillation(AF) has become a significant public health concern in China, with population aging and urbanization.Data screening was performed for 30,244,930 subjects medical insurance the Shanghai Municipal Health Commission database between 2015 2020. Patients diagnosed AF were identified further assessed treatment information clinical outcomes, as well sex differences impact of COVID-19 pandemic on managment.AF prevalence 0.88% Shanghai, which increased age reached 6.70% at 80 years...
Pulmonary hypertension (PH) is a severe clinical syndrome with pulmonary vascular remodeling and poor long-term prognosis. Neurotensin receptor 1 (Ntsr1), serve as one of the G protein-coupled receptors (GPCRs), implicates in various biological processes, but potential effects Ntsr1 PH development are unclear. The Sugen/Hypoxia (SuHx) or monocrotaline (MCT) induced rat model was used our study rats showed aggravated artery increased right ventricular systolic pressure (RVSP). Our results...
Silibinin is a traditional medicine and utilized for liver protection with antioxidant, anti-inflammation anti-apoptosis properties. However, its role in myocardial I/R injury the mechanism involved currently unknown. In present study, treatment improves cardiac function limits infarct size, subsequently inhibits fibrotic remodeling mice injury. Mechanistically, silibinin reduces cardiomyocytes apoptosis, attenuates mitochondrial impairment endoplasmic reticulum (ER) stress, alleviates ROS...
Endothelial progenitor cells (EPCs) play an important role in tissue repair after ischemic heart disease. In particular, the recovery of endothelial function is reliant on ability and rate EPCs differentiate into mature cells. The present study evaluated effect microRNA 107 (miR-107) mechanism differentiation. were isolated from rats' bone marrow miR-107 expression hypoxic normoxic conditions measured by real-time qualitative PCR. CD31 was analyzed flow cytometry eNOS examined PCR western...
Atrial-based pacing is associated with lower risk of atrial fibrillation (AF) in sick sinus syndrome compared ventricular pacing; nevertheless, the impact site and rate on progression AF remains unclear. We evaluated whether long-term at right (RA) appendage versus low RA septum (ON) or without (OFF) a continuous overdrive algorithm can prevent development persistent AF.We randomized 385 patients paroxysmal whom pacemaker was indicated to ON (n=98), OFF (n=99), (n=92), (n=96). The primary...
Cardiac hypertrophy is characterized by increased myofibrillogenesis. Angiotensin II (Ang-II) an essential mediator of the pressure overload-induced cardiac in part through RhoA/ROCK (small GTPase/Rho-associated coiled-coil containing protein kinase) pathway. FHOD3 (formin homology 2 domain 3), a cardiac-restricted member diaphanous-related formins, crucial regulating myofibrillogenesis cardiomyocytes. maintains inactive autoinhibition intramolecular interaction between its C- and N-terminal...
Dysfunction of endothelial progenitor cells (EPC) contribute to diabetic vascular disease. MicroRNAs (miRNAs) are key regulators diverse cellular processes, including angiogenesis. We recently reported that downregulated miR-130a in patients with Type 2 diabetes mellitus (DM) results EPC dysfunction, increased apoptosis, likely via its target runt-related transcription factor 3 (Runx3). However, whether affects the autophagy is unknown. The aim present study was explore effects on and cell...
Atrial fibrillation (AF) is a common arrhythmia with an important heritable aspect. The genetic factors underlying AF have not been fully elucidated.We screened six candidate genes (CAV1, KCNJ2, KCNQ1, NKX2.5, PITX2, and TBX5) for novel mutations in 139 patients of Chinese descent early-onset 576 controls. Four missense TBX5 mutations, p.R355C, p.Q376R, p.A428S, p.S372L, were identified evolutionarily conserved regions. We did find any CAV1, PITX2. These increased the expression atrial...