A5100759295- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Reconstructive Surgery and Microvascular Techniques
- Cardiac electrophysiology and arrhythmias
- Hepatitis B Virus Studies
- Cardiac pacing and defibrillation studies
- Hepatitis C virus research
- Reconstructive Facial Surgery Techniques
- Cleft Lip and Palate Research
- Liver Disease Diagnosis and Treatment
- Dental Implant Techniques and Outcomes
- Facial Trauma and Fracture Management
- Cardiac Imaging and Diagnostics
- Craniofacial Disorders and Treatments
- Bone fractures and treatments
- Cancer-related molecular mechanisms research
- Head and Neck Surgical Oncology
- Head and Neck Cancer Studies
- Bone Tumor Diagnosis and Treatments
- Periodontal Regeneration and Treatments
- Heart Rate Variability and Autonomic Control
- Bone Tissue Engineering Materials
- dental development and anomalies
- Bone Metabolism and Diseases
- Blood Pressure and Hypertension Studies
Shanghai Jiao Tong University
2016-2025
Weihai Chest Hospital
2025
Hebei Agricultural University
2025
Shanghai Ninth People's Hospital
2013-2024
Shanghai Public Health Clinical Center
2024
XinHua Hospital
2015-2024
Shanghai Sixth People's Hospital
2011-2024
Yancheng First People's Hospital
2024
Hôpital Civil, Strasbourg
2024
Xuzhou Medical College
2024
Background: Treatment of large bone defects represents a major clinical problem worldwide.Suitable substitute materials are commonly required to achieve successful regeneration, and much effort has been spent optimize their chemical compositions, 3D architecture mechanical properties.However, material-immune system interactions increasingly being recognized as crucial factor influencing regeneration.Here, we envisioned an accurate proactive immunomodulation strategy via delivery IL-4 (key...
The hostile oxidative wound microenvironment, defective angiogenesis, and uncontrolled release of therapeutic factors are major challenges in improving the diabetic healing. Herein, adipose-derived-stem-cell-derived exosomes (Exos) first loaded into Ag@bovine serum albumin (BSA) nanoflowers (Exos-Ag@BSA NFs) to form a protective "pollen-flower" delivery structure, which further encapsulated injectable collagen (Col) hydrogel NFs/Col) for concurrent remodeling microenvironment precise Exos....
The hydrophobic block of polymeric micelles formed by amphiphilic copolymers has no direct therapeutical effect, and the metabolites these segments might lead to some unexpected side effects. Here core is replaced highly water-insoluble drugs themselves, forming a new micellar drug delivery system. By grafting paclitaxel (PTX) onto surface hydrophilic hyperbranched poly(ether-ester) (HPEE), we constructed an copolymer (HPEE-PTX). HPEE-PTX could self-assemble into nanoparticles in aqueous...
In osteosarcoma (OS), chemotherapy resistance has become one of the greatest issues leading to high mortality among patients. However, mechanisms drug remain elusive, limiting therapeutic efficacy. Here, we set out explore relationship between dynamic histone changes and efficacy cisplatin against OS. First, found two demethylases associated with H3 lysine 27 trimethylation (H3K27me3) demethylation, KDM6A, KDM6B that were upregulated after treatment. Consistent clinical data,...
Abstract Tissue regeneration driven by immunomodulatory agents has emerged as a potential solution for repairing bone defects. However, the therapeutic benefits are compromised disturbances in pro‐ and anti‐inflammatory balance. Here, using magnesium nanoparticles (MgNPs) template, magnesium‐enriched graphene oxide nanoscrolls (MgNPs@GNSs) designed combinational modulation of inflammatory response reported. First, different effects (GO) ions (Mg 2+ ) on Raw264.7 macrophage phenotype...
Background Cyclin D1 (CCND1) has been associated with chemotherapy resistance and poor prognosis. In this study, we tested the hypothesis that CCND1 expression determines response clinical outcomes in locally advanced head neck squamous cell carcinoma (HNSCC) patients treated neoadjuvant followed by surgery radiotherapy. Methodology Findings 224 HNSCC were either cisplatin-based radiotherapy (neoadjuvant group, n = 100) or (non-neoadjuvant 124). was assessed immunohistochemistry. levels...
Abstract Objective Defects of the maxilla caused by tumor resection create high levels psychological and physical trauma for patients. The application osseointegrated dental implants using either an obturator prosthesis or a free vascularized flap has tremendously changed retention stability superstructure. However, no study been performed to compare function aforementioned two approaches quality life subjective assessments Materials methods Eligible patients who were treated with maxillary...
Upper extremity (UE) motor function impairment is a major poststroke complication whose recovery remains one of the most challenging tasks in neurological rehabilitation. This study examined efficacy and safety personalized neuroimaging-guided high-dose theta-burst stimulation (TBS) for UE recovery.
Background Functional reconstruction of the jaw defect due to tumor resection poses a challenging problem in maxillofacial surgery. The osteocutaneous fibula free flap combination with simultaneous or second stage insertion dental implants has exhibited growing popularity for such reconstructions. This study was aimed at evaluating clinical status and success rates inserted fibula-free flaps orofacial following ablation tumors. Methods We conducted follow-up based on 29 patients after oral...
Abstract Purpose The purpose of this study was twofold: (i) to compare vertical bone height ( VBH ) after tumor resection through grafting with either a double‐barrel fibula DBF technique or distraction osteogenesis the VDOF ); (ii) performance loaded dental implants following special focus on implant survival, success, and resorption. Materials methods This retrospective clinical involved 19 patients who underwent placement (group A , n = 9) B 10) for mandibular reconstruction from M arch...
Atrial fibrillation (AF) is a common arrhythmia with an important heritable aspect. The genetic factors underlying AF have not been fully elucidated.We screened six candidate genes (CAV1, KCNJ2, KCNQ1, NKX2.5, PITX2, and TBX5) for novel mutations in 139 patients of Chinese descent early-onset 576 controls. Four missense TBX5 mutations, p.R355C, p.Q376R, p.A428S, p.S372L, were identified evolutionarily conserved regions. We did find any CAV1, PITX2. These increased the expression atrial...
Mechanical ventilation has significant therapeutic benefits, but it may cause or aggravate lung injury, which is called ventilator-induced injury (VILI).Endogenous hydrogen sulfide (H2S) roles including regulating inflammation, and promoting vasodilatation; also exhibits anti-oxidative stress anti-fibrosis effects.H2S been reported to alleviate the effects mechanism of H2S on VILI remain unclear.The present study established a rat model treated them with H2S, then measured changes in...
Background: The aim of this study was to investigate the expression apoptosis‐inhibitory Bcl‐2 protein and apoptosis‐promoting Bax identify their association with clinical parameters prognosis patients oral squamous cell carcinoma (OSCC). Methods: proteins evaluated by immunohistochemical staining in specimens from 110 OSCC. Every section scored according both percentage positive tumor cells intensity. Kaplan‐Meier test Cox proportional hazards regression analysis were performed assess...
Multifunctional gene vectors with high transfection, low cytotoxicity, and good antitumor antibacterial activities were prepared from natural aminoglycosides. Through the Michael-addition polymerization of gentamycin N,N'-methylenebisacrylamide, cationic hyperbranched glycoconjugated polymers synthesized, their physical chemical properties analyzed by FTIR, (1)H NMR, (13)C GPC, ζ-potential, acid-base titration techniques. The cytotoxicity these polycations was because hydrolysis degradable...
BACKGROUND Polymer-infiltrated ceramic-network (PICN) dental material is a new and practical development in orthodontics. Sintering the process of forming stable solid mass from powder by heating without melting. The aim this study was to evaluate effects sintering temperature on mechanical properties PICN zirconia material. MATERIAL AND METHODS A dense ceramic four materials, with varying porosities, were sintered at three different temperatures; 12 materials based these porous ceramics...
The prognostic impact of left atrial appendage (LAA) patency, including those with and without visible peri-device leak (PDL), post-LAA closure in patients fibrillation, remains elusive.
Feline parvovirus (FPV) causes severe gastroenteritis and leukopenia in cats, with high morbidity mortality, necessitating a rapid effective antigen diagnostic test sensitivity specificity. In this study, platform based on combination of Recombinase-Aided Amplification (RAA) CRISPR/Cas12a was established for detecting FPV. Cas12a recombinant protein purified using Nickel-Nitriloacetic Acid resin after heterologous expression Escherichia coli . The results RAA-CRISPR/Cas12a can be detected...
<title>Abstract</title> <bold>BACKGROUND</bold> Atrial substrate remodeling (ASR) was emerged as a critical determinant of very late recurrence (VLR) in paroxysmal atrial fibrillation (PaAF). However, the multifaceted risk factors driving ASR progression and their interplay with clinical outcomes remain incompletely characterized. This study aimed to identify clinical, electrophysiological, structural associated PaAF patients experiencing VLR after catheter ablation (CA). <bold>METHODS...
Myocardial infarction (MI) induces neural remodelling of the left stellate ganglion (LSG), which may contribute to ischaemia-induced arrhythmias. The chemorepellent Semaphorin 3a (Sema3a) has been identified as a negative regulator sympathetic innervation in LSG and heart. We previously reported that overexpression Sema3a border zone could reduce arrhythmogenic effects cardiac hyperinnervation post-MI. This study investigated whether within confers an antiarrhythmic effect after MI through...