A5061005277- Head and Neck Cancer Studies
- Cutaneous Melanoma Detection and Management
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Salivary Gland Tumors Diagnosis and Treatment
- Ultrasound and Hyperthermia Applications
- Cancer-related molecular mechanisms research
- Cancer Diagnosis and Treatment
- Ear and Head Tumors
- Colorectal and Anal Carcinomas
- MicroRNA in disease regulation
- Oral Health Pathology and Treatment
- Cancer Research and Treatments
- Sarcoma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Circular RNAs in diseases
- Lung Cancer Research Studies
- Nonmelanoma Skin Cancer Studies
- Peptidase Inhibition and Analysis
- Vascular Tumors and Angiosarcomas
- Head and Neck Surgical Oncology
- Virus-based gene therapy research
- Immunotherapy and Immune Responses
- Infectious Diseases and Mycology
- Cholangiocarcinoma and Gallbladder Cancer Studies
Shanghai Ninth People's Hospital
2016-2025
Shanghai Jiao Tong University
2016-2025
Weifang Medical University
2019-2024
National Clinical Research Center for Digestive Diseases
2020-2023
Chinese Academy of Sciences
2021
Shanghai Institute of Microsystem and Information Technology
2021
National Clinical Research
2017
Abstract The Na + superionic conductor (NASICON)‐type 3 V 2 (PO 4 ) cathodes have attracted extensive interest due to their high structural stability and fast mobility. However, the substitution of vanadium with low‐cost active elements remains imperative cost vanadium, further boost its application feasibility. Herein, a novel ternary NASICON‐type VMn 0.5 Fe /C cathode is designed, which integrates advantages large reversible capacity, voltage, good stability. as‐obtained composite can...
Malignant melanoma is one of the most common malignancies. Its incidence grows rapidly at an annual rate 3−5%. Although remains low in China, it has increased rapidly, with approximately 20,000 new cases reported each year. The mortality also been increasing rapidly; contrast, although western countries, its basically unchanged and does not rise along escalation prevalence. Thus, there still a wide gap between China Western countries diagnosis treatment melanoma. Melanoma become diseases...
Oral mucosal melanoma (OMM) is a rare and aggressive subtype of with little known about its pathogenesis or carcinogenesis. We therefore performed whole-exome sequencing (WES) on 19 matched OMM tumor/normal pairs in order to gain insight into potential genetic drivers tumor formation. For the first time, we describe comprehensive mutational profile OMM. Our data suggest that background differs from those other subtypes. identified recurrent mutations involving KIT, POLE, PTPRD, PTCHD2,...
The antibody drug conjugate MRG003 comprises an anti-epidermal growth factor receptor (EGFR) humanized immunoglobulin G1 monoclonal that is conjugated with monomethyl auristatin E via a valine-citrulline linker. There currently insufficient evidence of this drug's safety and efficacy.To evaluate the maximum tolerated dose in phase 1a study investigate preliminary antitumor activity EGFR-expressing patients 1b study.This nonrandomized open-label, single-arm, 1, multicenter solid tumors was...
Background Cyclin D1 (CCND1) has been associated with chemotherapy resistance and poor prognosis. In this study, we tested the hypothesis that CCND1 expression determines response clinical outcomes in locally advanced head neck squamous cell carcinoma (HNSCC) patients treated neoadjuvant followed by surgery radiotherapy. Methodology Findings 224 HNSCC were either cisplatin-based radiotherapy (neoadjuvant group, n = 100) or (non-neoadjuvant 124). was assessed immunohistochemistry. levels...
Background Recent advances in novel targeted therapies have created the need for molecular characterization of cancer to allow accurate personalized treatments. In this study, our aim was investigate incidence activating mutations oncogenes BRAF , NRAS KIT and GNAQ / GNA 11 oral mucosal melanoma. Methods We analyzed a cohort 57 melanoma samples, including 27 frozen samples 30 formalin‐fixed paraffin‐embedded samples. The tumors were screened hotspot (exon 15), (exons 2 3), 9, 11, 13, 17), 5)...
Induction chemotherapy in oral squamous cell carcinoma is a controversial issue clinical practice. To investigate the evolution of cancer cells and tumor microenvironment (TME) response to carcinoma, single-cell transcriptome analysis was performed post-chemotherapy located cavity. The main types were identified based on gene expression patterns determined using dimensionality reduction unsupervised clustering. Non-negative matrix factorization clustering Cancer-associated fibroblasts (CAFs)...
To investigate the histopathological predictors of overall survival and metastatic failure oral mucosal melanoma (OMM), which classification microstaging has not been established.The pathological data, including cell type (CT), level invasion, ulceration, mitotic rate, pigmentation, necrosis, tumour-infiltrating lymphocyte (TIL) vascular 82 OMM patients from April 2002 to 2012 were reviewed analysed retrospectively. CT, necrosis invasion found be significance in predicting patients. CT was...
Since the inhibitory immune checkpoint receptors have been described to benefit OSCC patients clinically, it is unknown that whether their expression in tumor microenvironment (TME) can determine clinical outcome response nimotuzumab therapy.We examined patterns of (including TIM-3, LAG-3, PD-L1, and CTLA-4) an immunoregulatory enzyme called IDO 36 during therapy by immunohistochemistry. Then, we divided recruited into responders non-responders according computed tomography (CT) scan...
Rationale: The oncogenesis of head and neck squamous cell carcinoma (HNSCC) is believed to result from oncogene activation tumor suppressor inactivation. Here, we identified a new oncogenic role for the EREG gene in HNSCC. Methods: TCGA database immunohistochemistry assay were used analyze expression HNSCC tissues. Immunoblotting was performed identify EGFR-mediated pathways altered by EREG. investigated vivo vitro. Results: Upregulated predicted poor prognosis triggered transformation...
Background: To investigate the relationship between clinical and histopathological characteristics overall survival of patients with oral mucosal melanoma (OMM) without distal metastasis in order to provide predictive prognostic information OMM. Methods: Ki67 expression was assessed by immunohistochemistry 123 OMM distant metastases. The associations features (OS) were statistically analyzed. levels primary recurrent lesions from 14 compared. Results: Univariate analysis showed that tumor...
ABSTRACT Objectives The option is rare for patients with recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC) failed to prior‐line immune checkpoint inhibitors (ICIs) cetuximab‐based treatment. efficacy of salvage therapy was unsatisfied. Materials Methods We collected the clinical data R/M HNSCC progressed from immunotherapy cetuximab therapy, retrospectively analyzed toxicity anlotinib‐based in these patients. Results In total, 24 eligible participants were accrued...
Abstract Purpose: To identify the specific intratumoral and microenvironmental heterogeneity of acral (AM) mucosal melanoma (MM), we aimed to delineate their distinct cellular compositions, evolutionary trajectories, subtype-specific therapeutic strategies. Experimental Design: Single-cell transcriptomic genomic landscapes were analyzed across 42 samples (28 AM, 11 MM, 3 non-acral cutaneous [CM]), supplemented by in vitro vivo validation. Tumor stromal cells profiled using scRNA-seq,...
Abstract Background Recent evidence suggested a potential correlation between BMI and the efficacy of immune checkpoint inhibitors in cancer patients. This study aimed to evaluate prognostic value body mass index (BMI) recurrent/metastatic head neck squamous cell carcinoma (R/M HNSCC) patients treat with pembrolizumab. Methods The current retrospective cohort enrolled 49 R/M HNSCC underwent at least one cycle pembrolizumab as second‐line treatment from June 2018 October 2020. Survival...
Purpose:The prognosis of patients with recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC) that are refractory to programmed death protein 1 (PD-1) immunotherapy is relatively poor.The salvage therapy was rarely investigated urgently needed.Methods: We conducted a single center retrospective real-world study explore the efficacy cetuximab plus PD-1 inhibitors as in progressed from first-line immunotherapy.Results: In present study, 28 eligible were included between...
Mucosal melanoma (MM) is a rare but devastating subtype of melanoma. Our previous studies have demonstrated robust anti-tumor effects cyclin-dependent kinase 4/6 (CDK 4/6) inhibitors in head and neck MM (HNMM) patient-derived xenograft models with CDK4 amplification. Herein, we aimed to investigate the efficacy safety dalpiciclib (SHR6390), CDK4/6 inhibitor, HNMM patients harboring
Aim The purpose of this study was to explore the treatment and prognosis head neck rhabdomyosarcoma (RMS) in adults. Methods Fifty-nine patients with RMS adults (AHNRMS) treated one institution were selected. Multivariate analysis used evaluate various variables related overall survival (OS). Results estimated 5-year OS 36%. rate cervical lymph node (CLN) involvement 28%. Patients embryonic who underwent chemotherapy enjoyed a favorable outcome according multivariate (P = 0.047). Local...
Programmed death-ligand 1 (PD-L1) is a well-known immune checkpoint protein that helps cancer cells evade response. Anti-PD-L1 therapy has been approved for the treatment of several advanced human cancers. Therefore, further understanding regulatory mechanisms PD-L1 critical to improve PD-L1-targeting immunotherapy. Recent studies indicated contact-dependent pathways may regulate anticancer immunity, highlighting importance cell contact-induced signaling in immunity. Here, we show tumor...
Abstract Background Oral mucosal melanoma (OMM) is a clinically rare disease with poor prognosis. Various treatment methods have been investigated the aim of improving This study aimed to analyze data single institution in management OMM. Methods A total 78 consecutive OMM patients were included this retrospective study. The intraoral lesion was treated either by cryotherapy, surgery or both; neck dissection observation; post-operative chemotherapy dimethyl triazeno imidazole carboxamide and...