A5101501031- Nanoplatforms for cancer theranostics
- Glioma Diagnosis and Treatment
- Advanced Image Processing Techniques
- Advanced Radiotherapy Techniques
- Radiomics and Machine Learning in Medical Imaging
- Digital Holography and Microscopy
- Cancer, Hypoxia, and Metabolism
- Image Enhancement Techniques
- Advanced X-ray and CT Imaging
- Lung Cancer Diagnosis and Treatment
- Image and Signal Denoising Methods
- Random lasers and scattering media
- Medical Image Segmentation Techniques
- Optical Coherence Tomography Applications
- Brain Tumor Detection and Classification
- Brain Metastases and Treatment
- Advancements in Transdermal Drug Delivery
- Gastrointestinal motility and disorders
- Reproductive System and Pregnancy
- Photodynamic Therapy Research Studies
- Advanced X-ray Imaging Techniques
- Advanced biosensing and bioanalysis techniques
- Dermatology and Skin Diseases
- Photoacoustic and Ultrasonic Imaging
- Mast cells and histamine
Beijing University of Technology
2022-2024
Wuhan University
2024
Renmin Hospital of Wuhan University
2024
Tianjin Medical University General Hospital
2014-2023
Ocean University of China
2022-2023
Anyang Hospital of Traditional Chinese Medicine
2023
Beijing Friendship Hospital
2022
Capital Medical University
2022
National Clinical Research Center for Digestive Diseases
2022
China-Japan Friendship Hospital
2021
In cancer radiotherapy, the lack of fixed DNA damage by oxygen in hypoxic microenvironment solid tumors often leads to severe radioresistance. Nitric oxide (NO) is a potent radiosensitizer that acts two ways. It can directly react with radical thus fixing damage. also normalizes abnormal tumor vessels, thereby increasing blood perfusion and supply. To achieve these functions, dosage duration NO treatment need be carefully controlled, otherwise it will lead exact opposite outcomes. However,...
Abstract The development of painless hair loss therapy without side‐effect is challenging. dermal papilla the signal center follicles and plays a key role in regulation their cycling. Activation cells (DPCs) would promote regeneration. In this study, separable microneedle patch comprised chitosan lactate (CL) exosomes (EXO) from adipose‐derived stem fabricated. After insertion into skin, hyaluronic acid substrate dissolves fast swellable polyvinyl alcohol needles are retained. EXO...
The antibody drug conjugate MRG003 comprises an anti-epidermal growth factor receptor (EGFR) humanized immunoglobulin G1 monoclonal that is conjugated with monomethyl auristatin E via a valine-citrulline linker. There currently insufficient evidence of this drug's safety and efficacy.To evaluate the maximum tolerated dose in phase 1a study investigate preliminary antitumor activity EGFR-expressing patients 1b study.This nonrandomized open-label, single-arm, 1, multicenter solid tumors was...
Abstract Radiosensitizers hold great promise for enhanced cancer radiotherapeutics. However, apoptosis evasion of cancerous cells usually limits the efficiency radiosensitive strategies. Herein, an in situ self‐assembled supramolecular antagonist is developed to reinforce treatment outcome radiotherapy by inhibiting tumor evasion. The composed peptide functionalized with apoptosis‐inducing SmacN7 and alkaline phosphatase (ALP)‐responsive group. Upon reaching site, can form membrane‐localized...
IR780, a near-infrared dye, can also be used as photosensitizer both for photothermal therapy (PTT) and photodynamic (PDT). In this study, we designed simple but effective nanoparticle system carrying IR780 paclitaxel, thus hoping to combine PTT/PDT chemotherapy treat hepatocellular carcinoma (HCC). This nanosystem, named PDF nanoparticles, consisted of phospholipid/Pluronic F68 complex nanocores pullulan shells. paclitaxel were loaded separately into nanoparticles form PDFI PDFP which had...
The radiotherapy modulators used in clinic have disadvantages of high toxicity and low selectivity. For the first time, we situ enzyme-instructed self-assembly (EISA) a peptide derivative (Nap-GDFDFpYSV) to selectively enhance sensitivity cancer cells with alkaline phosphatase (ALP) expression ionizing radiation (IR). Compared vitro pre-assembled control formed by same molecule, assemblies EISA greatly sensitized ALP-high-expressing γ-rays, remarkable sensitizer enhancement ratio. Our...
Photothermal agents with high photothermal transfer efficiencies in the near-infrared (NIR) region are important for enhanced therapy (PTT) of tumors. Herein, we developed a strategy acid-triggered situ aggregation system based on peptide-conjugated gold nanoparticles (GNPs). In an acidic environment, GNPs formed large aggregates solution, cell lysates, and tumor tissues, as observed by transmission electron microscopy (TEM). As consequence aggregation, their UV–vis absorbance NIR was...
Abstract Vasculogenic mimicry (VM) constitutes a novel approach for tumour blood supply and contributes to metastasis poor prognosis in patients with melanoma. Myoferlin (MYOF), type II membrane protein involved regeneration repair, is elevated several malignant tumours, especially advanced melanomas. This study aims investigate the role mechanism of MYOF regulation VM. VM structures were found 14 52 tested melanoma samples, high expression correlated structures. According Kaplan–Meier...
Novel cyclodextrin derivative, glutamine-β-cyclodextrin, is developed as DOX carrier to minimize its side effects <italic>via</italic> TNBC tumors addiction glutamine.
The use of a novel coassembled peptide hydrogel enhanced the radiosensitization effect cisplatin by increasing number Pt–DNA adducts, arresting cell cycle, and promoting inhibition cyclooxygenase-2.
Optical aberrations introduced by sample or system elements usually degrade the image quality of a microscopic imaging system. Computational adaptive optics has unique advantages for 3D biological since neither bulky wavefront sensors nor complicated indirect sensing procedures are required. In this paper, stochastic parallel gradient descent computational method is proposed high-efficiency aberration correction in fluorescent incoherent digital holographic microscope. The algorithm...
Multimodality imaging-navigated precise phototherapy has been well-established as a promising strategy for enhancing the diagnostic and therapeutic efficiency of cancer in preclinical trials. However, proper theranostic agents with adequate biosafety biological efficacy well simple components preparations are still great demand to promote clinical translation this regimen. Here, we developed multifunctional nanosystem based on self-assembly FDA-approved indocyanine green (ICG) 125I-labeled...
// Chao Cao 1 , Ning Xu Xiaoxia Zheng Wenxue Zhang Tianwen Lai 2 Zaichun Deng 3 and Xiaoping Huang Department of Respiratory Medicine, Ningbo First Hospital, Ningbo, China Respiratory, Institute Diseases, The Affiliated Hospital Guangdong Medical University, Zhanjiang, University School Correspondence to: Huang, email: xiaopinghuang@126.com Deng, dengzaichun982136@hotmail.com Lai, laitianwen2011@163.com Keywords: MMP-2, TIMP-2, lung cancer, diagnosis, biomarker Received: March 24, 2017...