A5012593806- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- Collagen: Extraction and Characterization
- Hepatitis B Virus Studies
- Cancer-related molecular mechanisms research
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Ubiquitin and proteasome pathways
- Cancer, Hypoxia, and Metabolism
- Cell Adhesion Molecules Research
- Silk-based biomaterials and applications
- Cancer Immunotherapy and Biomarkers
- Advanced X-ray and CT Imaging
- Periodontal Regeneration and Treatments
- Aquaculture Nutrition and Growth
- Cancer Genomics and Diagnostics
- Cancer, Lipids, and Metabolism
- Cancer-related gene regulation
- Industrial Vision Systems and Defect Detection
- Bone Tissue Engineering Materials
- Biological Stains and Phytochemicals
- Heat shock proteins research
- Agriculture and Biological Studies
- Molecular Sensors and Ion Detection
Henan University
2025
Tianjin Medical University Cancer Institute and Hospital
2017-2024
Shanghai Civil Aviation College
2020-2024
Tianjin University of Traditional Chinese Medicine
2024
Shenyang Research Institute of Foundry
2022-2024
Shanghai Ocean University
2020-2023
Chinese University of Hong Kong
2023
Southwest Minzu University
2022
Peking University First Hospital
2019-2021
Peking University
2019-2021
Abstract Hepatitis B virus (HBV) infection is a major driver of hepatocarcinogenesis. Ferroptosis type iron-mediated cell death that can suppress liver transformation. Previous studies have linked HBV to ferroptosis in fibrosis and acute failure. However, whether involved HBV-mediated cancer poorly understood. Here, we identified heat shock protein family A member 8 (HSPA8) as crucial host factor modulates replication cancer. X (HBx) upregulated HSPA8 by coactivating the transcription 1...
Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a broadly expressed lncRNA involved in many aspects of cellular processes. To further delineate the underlying molecular mechanism, we employed high-throughput strategy to characterize interacting proteins MALAT1 by combining RNA pull-down, quantitative proteomics, bioinformatics, and experimental validation. Our approach identified 127 potential MALAT1-interacting established highly connected interactome network consisting...
Collagen from fish has been proven to have a low antigenicity that no difference in the genetic codes compared with mammalian-based collagen. This study was designed investigate impact of tilapia skin collagen on immunogenicity and biocompatibility vivo vitro. The structural characteristics both acid-soluble pepsin-soluble (ASC PSC), determined using SDS-PAGE atomic force microscopy imaging experiments, revealed had basic type I (COL-I). vitro collagens showed good cell proliferation against...
Background & AimsThe programmed death-ligand 1 (PD-L1) is a major co-inhibitory checkpoint factor that controls T cell activities in tumors. PD-L1 expressed on immune cells and tumor cells. Whether cell-expressed affects an cell-independent fashion remains largely elusive. Here, we investigated the significance of with focus downstream signals changes lipid metabolism.MethodsImmune-independent functions growth were vitro immuno-deficient mice vivo. The global influence targeted/untargeted...
Abstract Viral immune evasion is crucial to the pathogenesis of hepatitis B virus (HBV) infection. However, role HBV in modulation innate poorly understood. A liver‐specific histone acetyltransferase 1 ( Hat1 ) knockout (KO) mouse model and HAT1 KO cell line were established. Immunohistochemistry staining, Western blot analysis, Southern Northern immunofluorescence assays, enzyme‐linked immunosorbent assay, reverse transcription‐quantitative polymerase chain reaction, chromatin...
Abstract Background NUAK1 is associated with metastasis and drug resistance in hepatocellular carcinoma (HCC). However, little known about the immune functions of HCC. Therefore, aim this study was to elucidate novel role facilitating evasion HCC investigate mechanisms underpinning process. Method The levels expression infiltration CD8 + T cells were assessed tumor tissues from patients mice xenograft model. cell lines used validate regulating transcription PD-L1, diethylnitrosamine-induced...
Novel cyclodextrin derivative, glutamine-β-cyclodextrin, is developed as DOX carrier to minimize its side effects <italic>via</italic> TNBC tumors addiction glutamine.
Fish collagen has been widely used in tissue engineering (TE) applications as an implant, which is generally transplanted into target with stem cells for better regeneration ability. In this case, the success rate of research depends on fundamental components fish such amino acid composition, structural and rheological properties. Therefore, researchers have trying to find innovative raw material from marine origins applications. Based concept, collagens acid-soluble (ASC) pepsin-soluble...
Abstract Collagen is widely used for dental therapy in several ways such as films, 3D matrix, and composites, besides traditional Chinese medicine (TCM), has been tissue regeneration wound healing application centuries. Hence, the present study was targeted first time to fabricate collagen film with TCM resveratrol celastrol order investigate human periodontal ligament fibroblasts (HPLF) growth bone marrow macrophages (BMM) derived osteoclastogenesis. Further, physicochemical, mechanical...
Fibrillins are microfibril-associated macro glycoproteins found in connective tissues and structurally related to latent TGF-β-binding proteins (LTBPs). The special cellular immunity blocking glycoprotein receptors IIb IIIa of fibrillins emerging topics recent years. In this study, Nile Tilapia type IIcollagen (NTCII) was extracted purified from the skull cartilages by a pepsin-soluble method. Amino acid analysis indicated that NTCII consisted 315/1000 glycine residues, 72/1000...
Abstract Accurate clinical diagnosis of the stage tumor development is essential for formulating a treatment plan. However, tongue among malignant, benign and leukoplakia easily misdiagnosed, resulting differing approaches, taking patients in danger preventing them from receiving deserved care. This study aimed to establish an automatic recognition system tumors at different stages using artificial intelligence methods along with pathological tissue section images. By improving Swin...
Clinically, the persistence of HBV cccDNA is major obstacle in anti-HBV therapy. However, underlying mechanism poorly understood. The transcriptional factor STAT3 able to activate replication liver.