A5043053831- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Hepatitis B Virus Studies
- Hepatitis C virus research
- RNA Interference and Gene Delivery
- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- Ubiquitin and proteasome pathways
- Cancer-related gene regulation
- CRISPR and Genetic Engineering
- Cancer, Lipids, and Metabolism
- MicroRNA in disease regulation
- Transplantation: Methods and Outcomes
- Rabies epidemiology and control
- Virology and Viral Diseases
- Cancer, Hypoxia, and Metabolism
- RNA and protein synthesis mechanisms
- Virus-based gene therapy research
- Peptidase Inhibition and Analysis
- Histone Deacetylase Inhibitors Research
- Protein Degradation and Inhibitors
- PI3K/AKT/mTOR signaling in cancer
Tianjin Medical University Cancer Institute and Hospital
2021-2024
Longyan University
2021
Shaoxing University
2013
Abstract Hepatitis B virus (HBV) infection is a major driver of hepatocarcinogenesis. Ferroptosis type iron-mediated cell death that can suppress liver transformation. Previous studies have linked HBV to ferroptosis in fibrosis and acute failure. However, whether involved HBV-mediated cancer poorly understood. Here, we identified heat shock protein family A member 8 (HSPA8) as crucial host factor modulates replication cancer. X (HBx) upregulated HSPA8 by coactivating the transcription 1...
Background & AimsThe programmed death-ligand 1 (PD-L1) is a major co-inhibitory checkpoint factor that controls T cell activities in tumors. PD-L1 expressed on immune cells and tumor cells. Whether cell-expressed affects an cell-independent fashion remains largely elusive. Here, we investigated the significance of with focus downstream signals changes lipid metabolism.MethodsImmune-independent functions growth were vitro immuno-deficient mice vivo. The global influence targeted/untargeted...
Nucleus(t)ide analogs (NAs), containing Lamivudine (LMV), adefovir dipivoxil (ADV), endeavor (ETV), telbivudine (LdT), and tenofovir (TDF) are widely used for the treatment of chronic hepatitis B (CHB), but long term anti-Hepatitis virus (HBV) therapy with NAs may give rise to emergence drug-resistant viral mutants.This study aimed find identify some new resistance mutations HBV from patients accepted anti-HBV therapy.The reverse transcriptase (RT) coding region was PCR-amplified using DNA...
Protein arginine methyltransferase 5 (PRMT5) acts as an oncogene in liver cancer, yet its roles and in-depth molecular mechanisms within the cancer immune microenvironment remain mostly undefined. Here, we demonstrated that disruption of tumor-intrinsic PRMT5 enhances CD8+ T-cell-mediated antitumor immunity both vivo vitro. Further experiments verified this effect is achieved through downregulation inhibitory checkpoint molecule, fibrinogen-like protein 1 (FGL1). Mechanistically, catalyzed...
<div>Abstract<p>Hepatitis B virus (HBV) infection is a major driver of hepatocarcinogenesis. Ferroptosis type iron-mediated cell death that can suppress liver transformation. Previous studies have linked HBV to ferroptosis in fibrosis and acute failure. However, whether involved HBV-mediated cancer poorly understood. Here, we identified heat shock protein family A member 8 (HSPA8) as crucial host factor modulates replication cancer. Hepatitis X (HBx) upregulated HSPA8 by...
<p>Supplementary materials and methods, Supplementary figures, figure legends, tables</p>
<div>Abstract<p>Hepatitis B virus (HBV) infection is a major driver of hepatocarcinogenesis. Ferroptosis type iron-mediated cell death that can suppress liver transformation. Previous studies have linked HBV to ferroptosis in fibrosis and acute failure. However, whether involved HBV-mediated cancer poorly understood. Here, we identified heat shock protein family A member 8 (HSPA8) as crucial host factor modulates replication cancer. Hepatitis X (HBx) upregulated HSPA8 by...
<p>Supplementary materials and methods, Supplementary figures, figure legends, tables</p>
<p>HBXIP is required for the up-regulation of Cyclin A, eIF4E and LDHA.</p>
<p>Supplementary materials and methods, Supplementary figures, figure legends, tables</p>
<div>Abstract<p>Hepatitis B virus (HBV) infection is a major driver of hepatocarcinogenesis. Ferroptosis type iron-mediated cell death that can suppress liver transformation. Previous studies have linked HBV to ferroptosis in fibrosis and acute failure. However, whether involved HBV-mediated cancer poorly understood. Here, we identified heat shock protein family A member 8 (HSPA8) as crucial host factor modulates replication cancer. Hepatitis X (HBx) upregulated HSPA8 by...
<p>Supplementary materials and methods, Supplementary figures, figure legends, tables</p>
Hepatitis B is a chronic infectious disease caused by hepatitis virus (HBV) infection, with liver inflammatory lesions as the main clinical manifestation, and continuous replication of HBV can lead to abnormal function, cirrhosis, even cancer. At present, variety anti-HBV drugs have been applied in practice, but no satisfactory therapeutic effect has achieved. Therefore, it urgent develop new constantly update concept treatment. This article reviews research advances that block interaction...