A5100393882- Cancer Genomics and Diagnostics
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cleft Lip and Palate Research
- Esophageal Cancer Research and Treatment
- Cancer-related molecular mechanisms research
- Pancreatic and Hepatic Oncology Research
- RNA modifications and cancer
- Endometrial and Cervical Cancer Treatments
- Formal Methods in Verification
- Video Surveillance and Tracking Methods
- Anomaly Detection Techniques and Applications
- Real-Time Systems Scheduling
- Circular RNAs in diseases
- Genetic factors in colorectal cancer
- Embedded Systems Design Techniques
- Supramolecular Self-Assembly in Materials
- Nasal Surgery and Airway Studies
- Cancer Immunotherapy and Biomarkers
- Craniofacial Disorders and Treatments
- Renal cell carcinoma treatment
- Cerebrovascular and genetic disorders
- Cancer Cells and Metastasis
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Telomeres, Telomerase, and Senescence
- Transplantation: Methods and Outcomes
Peking University
2006-2025
Peking University Third Hospital
2024-2025
Sichuan University
2023-2025
State Key Laboratory of Oral Diseases
2023-2025
China Medical University
2025
Yunnan University
2024
Beijing Obstetrics and Gynecology Hospital
2024
Capital Medical University
2023-2024
Peking University First Hospital
2024
Beijing YouAn Hospital
2023
In acral melanoma (AM), progression from in situ (AMis) to invasive AM (iAM) leads significantly reduced survival. However, evolutionary dynamics during this process remain elusive. Here, we report integrative molecular and spatial characterization of 147 AMs using genomics, bulk single-cell transcriptomics, transcriptomics proteomics. Vertical invasion AMis iAM displays an early monoclonal seeding pattern. The subsequent regional expansion exhibits two distinct patterns, clonal subclonal...
Lymphatic metastases are closely associated with tumor relapse and reduced survival in colorectal cancer (CRC). How cells disseminate within the lymphatic network remains largely unknown. Here, we analyze subclonal structure of 94 samples, covering primary tumors, lymph node (LNMs), liver from 10 CRC patients. We portray a high-resolution metastatic map for by dividing LNMs into paracolic, intermediate, central subgroups. Among 61 routes identified, 38 (62.3%) initiated 22 (36.1%) LNMs, 1...
Abstract Intrahepatic cholangiocarcinoma (ICC) is highly heterogeneous. Here, the authors perform exome sequencing and bulk RNA on 73 tumor regions from 14 ICC patients to portray multi‐faceted intratumor heterogeneity (ITH) landscape of ICC. The show that ITH concordant across genomic, transcriptomic, immune levels. Comparison these data 8 published datasets reveals significantly higher degrees in than hepatocellular carcinoma. Remarkably, find high‐ITH tumors overlap with IDH (isocitrate...
Chaoshan region, a littoral area of Guangdong province in southern China, has high incidence esophageal squamous cell carcinoma (ESCC). At present, the prognosis ESCC is still very poor, therefore, there urgent need to seek valuable molecular biomarker for prognostic evaluation guide clinical treatment. GPX2, selenoprotein, was exclusively expressed gastrointestinal tract and an anti-oxidative damage anti-tumour effect progress tumourigenesis.We collected 161 patients samples, among which 83...
Chronic inflammation is associated with increased risk of cancer development, whereas the link between chronic and esophageal carcinogenesis still obscure heretofore. This study aimed to investigate relationship DNA damage, as well possible role damage in carcinogenic process. Endoscopic biopsies from 109 individuals Chaoshan littoral, a high-risk region for squamous cell carcinoma (ESCC), were examined evaluate association histological severity, while additional 204 non-tumor samples...
Primary liver tissue cancer types are renowned to display a consistent increase in global disease burden and mortality, thus needing more effective diagnostics treatments. Yet, integrative research efforts identify cell-of-origin for these cancers by utilizing human specimen data were poorly established. To this end, we analyzed previously published whole-genome sequencing 384 tumor progenitor tissues along with 423 publicly available normal epigenomic features single cell RNA-seq from...
Kinesin family member 13B (KIF13B), a crucial motor protein, exerts multiple cellular biological functions. However, the implication of KIF13B in metabolic dysfunction-associated fatty liver disease (MAFLD) has not been explored yet. This study aimed to investigate KIF13B's role and underlying mechanism MAFLD proposes it as potential pharmacological target. We assessed expression patients rodent models. The roles Kif13b lipid metabolism were investigated using whole-body knockout mice,...
Cleft palate is a congenital malformation influenced by both genetic and environmental factors. Although contributors have been extensively studied, the placenta-an essential organ that mediates maternal-fetal interactions offers protection against insults-remains poorly understood in this context. This study aimed to explore transcriptomic metabolomic alterations placenta following maternal exposure corticosteroids, using dexamethasone-induced cleft rabbit model. Untargeted metabolomics...
Many patients who receive lung transplantation (LT) operations develop varying degrees of bronchiolitis obliterans (BO) after the surgeries. Epithelial-mesenchymal transition (EMT) is considered to be related process obliterans. In this study we simulated pathological post-lung obliterans, and explored correlation between BO EMT small airway epithelial cells. We transplanted left lungs F344 rats Lewis by Tri-cuff anastomosis established allogeneic rat orthotopic model. Cyclosporine...
Background: Cervical cancer is the most common malignant tumor in female reproductive system, while efficacy of routine screening strategy unsatisfied.New molecular tests need to be developed.miRNAs participate many pathologic processes, and circulating miRNAs are promising non-invasive biomarkers tumors.Objectives: This study aimed identify associated with both cervical intraepithelial neoplasia (CIN), establish a classifier for lesions using miRNAs.Methods: consisted 5 steps: screening,...
Dunaliella salina, a single-celled marine alga with extreme salt tolerance, is an important model organism for studying fundamental extremophile survival mechanisms and their potential practical applications. In this study, two-dimensional differential in-gel electrophoresis (2D-DIGE) was used to investigate the expression of halotolerant proteins under high (3 M NaCl) low (0.75 concentrations. Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF/TOF MS)...
Aneurysmal subarachnoid hemorrhage (aSAH) necessitating mechanical ventilation (MV) presents a serious challenge for intensivists. Laboratory blood tests reflect individual physiological and biochemical states, provide useful tool identifying patients with critical condition stratifying risk levels of death. This study aimed to determine the prognostic role initial routine laboratory in these patients.This retrospective cohort included 190 aSAH requiring MV neurosurgical intensive care unit...